Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
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TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
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Microwave-assisted incorporation of silver nanoparticles in paper for point-of-use water purification.
TL;DR: This work reports an environmentally benign method for the in situ preparation of silver nanoparticles (AgNPs) in paper using microwave irradiation, which was effective in inactivating the test bacteria as they passed through the paper.
Journal ArticleDOI
Silver confined within zeolite EMT nanoparticles: preparation and antibacterial properties
Biao Dong,Biao Dong,S. Belkhair,Moussa Zaarour,Leanne E. Fisher,Joanna Verran,Lubomira Tosheva,Richard Retoux,Jean-Pierre Gilson,Svetlana Mintova +9 more
TL;DR: The Ag(0-EMT samples show slightly enhanced antimicrobial efficacy compared to that of Ag(+)-EMT, however, the differences are not substantial and the preparation of Ag nanoparticles is not viable considering the complexity of preparation steps.
Journal ArticleDOI
Impact of polymer-coated silver nanoparticles on marine microbial communities: a microcosm study.
TL;DR: This study clearly demonstrated that at low concentrations (5 and 50 μg L(-1) total silver), un-aggregated polymer-coated AgNPs and dissolved Ag(+) contamination produced similar effects: a longer lag phase suggesting an adaptation period for microorganisms.
Journal ArticleDOI
Governing factors affecting the impacts of silver nanoparticles on wastewater treatment.
TL;DR: It is argued that the biological effects of silver nanoparticles at environmentally realistic concentrations (μgL-1 or lower) on the performance of a full-scale municipal water resource recovery facility (WRRF) are minimal.
Journal ArticleDOI
Natural water chemistry (dissolved organic carbon, pH, and hardness) modulates colloidal stability, dissolution, and antimicrobial activity of citrate functionalized silver nanoparticles
TL;DR: In this article, the effects of three critical water chemistry parameters (DOC, pH, and hardness) on the colloidal stability, dissolution dynamics, and antimicrobial activity of citrate-functionalized AgNPs (citrate-AgNPs) against Escherichia coli were investigated.
References
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Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
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