Journal ArticleDOI
Negligible Particle-Specific Antibacterial Activity of Silver Nanoparticles
Reads0
Chats0
TLDR
This work suggests that AgNP morphological properties known to affect antimicrobial activity are indirect effectors that primarily influence Ag(+) release, and antibacterial activity could be controlled by modulating Ag(+ release, possibly through manipulation of oxygen availability, particle size, shape, and/or type of coating.Abstract:
For nearly a decade, researchers have debated the mechanisms by which AgNPs exert toxicity to bacteria and other organisms. The most elusive question has been whether the AgNPs exert direct “particle-specific” effects beyond the known antimicrobial activity of released silver ions (Ag+). Here, we infer that Ag+ is the definitive molecular toxicant. We rule out direct particle-specific biological effects by showing the lack of toxicity of AgNPs when synthesized and tested under strictly anaerobic conditions that preclude Ag(0) oxidation and Ag+ release. Furthermore, we demonstrate that the toxicity of various AgNPs (PEG- or PVP- coated, of three different sizes each) accurately follows the dose–response pattern of E. coli exposed to Ag+ (added as AgNO3). Surprisingly, E. coli survival was stimulated by relatively low (sublethal) concentration of all tested AgNPs and AgNO3 (at 3–8 μg/L Ag+, or 12–31% of the minimum lethal concentration (MLC)), suggesting a hormetic response that would be counterproductive t...read more
Citations
More filters
Journal ArticleDOI
Silver-Incorporated Mussel-Inspired Polydopamine Coatings on Mesoporous Silica as an Efficient Nanocatalyst and Antimicrobial Agent.
TL;DR: The constructed dual-functional SBA-15/PDA/Ag as the long-term antimicrobial agent and the catalyst of industrial products provides an integrated nanoplatform to deal with environmental concerns.
Journal ArticleDOI
Advances and challenges for the use of engineered nanoparticles in food contact materials
Joseph Christopher Hannon,Joseph P. Kerry,Malco C. Cruz-Romero,Michael A. Morris,Enda Cummins +4 more
TL;DR: In this paper, a risk assessment strategy and policy developments associated with the use of nanotechnology in food contact materials (FCMs) are discussed. But the absence of a regulatory framework for NP FCMs has been highlighted as a drawback for the development of nanoparticle FCMs, a NP specific exposure framework providing prompt risk assessment could be invaluable to industry, consumers and regulatory bodies.
Journal ArticleDOI
Silver nanoparticles boost charge-extraction efficiency in Shewanella microbial fuel cells.
Bocheng Cao,Zipeng Zhao,Lele Peng,Hui-Ying Shiu,Mengning Ding,Frank Song,Xun Guan,Calvin K. Lee,Jin Huang,Dan Zhu,Xiaoyang Fu,Gerard C. L. Wong,Chong Liu,Kenneth H. Nealson,Paul S. Weiss,Xiangfeng Duan,Yu Huang +16 more
TL;DR: In this paper, the authors proposed a method to directly convert the chemical energy stored in organic matter to electricity and are of considerable interest for power generation and wastewater treatment using microbial fuel cells (MFCs).
Journal ArticleDOI
Cytidine-stabilized gold nanocluster as a fluorescence turn-on and turn-off probe for dual functional detection of Ag(+) and Hg(2+).
TL;DR: Fluorescence enhanced Au NCs by doping Ag(+) can be conveniently reusable for the detection of Hg(2+) based on the corresponding fluorescence quenching and could be utilized as a convenient, dual functional, rapid response, and label-free fluorescence sensor for related environmental and health monitoring.
Journal ArticleDOI
Toxicity mechanisms and synergies of silver nanoparticles in 2,4-dichlorophenol degradation by Phanerochaete chrysosporium.
Zhenzhen Huang,Guiqiu Chen,Guangming Zeng,Zhi Guo,Kai He,Liang Hu,Jing Wu,Lihua Zhang,Yuan Zhu,Zhongxian Song +9 more
TL;DR: Results suggested that AgNPs-induced cytotoxicity could arise from the "Trojan-horse" mechanism executing particle effects, ion effects, or both, ruling out extracellularly released Ag+.
References
More filters
Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Journal ArticleDOI
Antimicrobial effects of silver nanoparticles
Jun Sung Kim,Eunye Kuk,Kyeong Nam Yu,Jong-Ho Kim,Sungjin Park,Hu Jang Lee,So Hyun Kim,Young Kyung Park,Yong Ho Park,Cheol Yong Hwang,Yong-Kwon Kim,Yoon-Sik Lee,Dae Hong Jeong,Myung-Haing Cho +13 more
TL;DR: The results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
Journal ArticleDOI
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
TL;DR: This is the first comparative study on the bactericidal properties of silver nanoparticles of different shapes, and the results demonstrate thatsilver nanoparticles undergo a shape-dependent interaction with the gram-negative organism E. coli.
Journal ArticleDOI
Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells
TL;DR: A possible mechanism of toxicity is proposed which involves disruption of the mitochondrial respiratory chain by Ag-np leading to production of ROS and interruption of ATP synthesis, which in turn cause DNA damage.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
Related Papers (5)
Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli.
Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria
Ivan Sondi,Branka Salopek-Sondi +1 more