NMR solution structure of C2 domain of MFG-E8 and insights into its molecular recognition with phosphatidylserine
Hong Ye,Baihong Li,Vivekanandan Subramanian,Bo-Hwa Choi,Yu Liang,Amaravadhi Harikishore,Goutam Chakraborty,Kwanghee Baek,Ho Sup Yoon,Ho Sup Yoon +9 more
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TLDR
The solution structure of the C2 domain of MFG-E8 is determined by nuclear magnetic resonance (NMR) spectroscopy, and the molecular basis of binding between the C1 domain and PS is characterized by (31)P-NMR spectroscopic.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-03-01 and is currently open access. It has received 29 citations till now. The article focuses on the topics: C2 domain & Protein structure.read more
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Journal ArticleDOI
Phosphatidylserine in the brain: metabolism and function.
TL;DR: Improvement of some memory functions has been observed in cognitively impaired subjects as a result of PS supplementation, but the mechanism is unclear.
Journal ArticleDOI
Phosphatidylserine receptors: enhancers of enveloped virus entry and infection
Sven Moller-Tank,Wendy Maury +1 more
TL;DR: This review provides an overview of PtdSer receptors that serve as PVEERs and the biology behind virion/PVEER interaction.
Dissertation
Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice
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Lactadherin: An unappreciated haemostasis regulator and potential therapeutic agent.
TL;DR: Recent knowledge on the possible role of lactadherin in haemostasis control is summarized, emphasizing the great significance of the interaction between lactadHERin and PS expressed on activated platelets and extracellular vesicles.
Journal ArticleDOI
The glycoproteins EDIL3 and MFGE8 regulate vesicle-mediated eggshell calcification in a new model for avian biomineralization.
TL;DR: A model in which EDIL3 and, to a lesser extent, MFGE8 proteins guide vesicle containing amorphous calcium carbonate to the mineralization site was proposed, supported by the observation that extracellular vesicles accumulate in uterine fluid during eggshell calcification and that they contain high levels of calcium, carbon, and oxygen that correspond to calcium carbonates.
References
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Journal ArticleDOI
PROCHECK: a program to check the stereochemical quality of protein structures
TL;DR: The PROCHECK suite of programs as mentioned in this paper provides a detailed check on the stereochemistry of a protein structure and provides an assessment of the overall quality of the structure as compared with well refined structures of the same resolution.
Journal ArticleDOI
SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.
Nicolas Guex,Manuel C. Peitsch +1 more
TL;DR: An environment for comparative protein modeling is developed that consists of SWISS‐MODEL, a server for automated comparativeprotein modeling and of the SWiss‐PdbViewer, a sequence to structure workbench that provides a large selection of structure analysis and display tools.
Journal ArticleDOI
Electrostatics of nanosystems: Application to microtubules and the ribosome
TL;DR: The application of numerical methods are presented to enable the trivially parallel solution of the Poisson-Boltzmann equation for supramolecular structures that are orders of magnitude larger in size.
Journal ArticleDOI
Development and validation of a genetic algorithm for flexible docking.
TL;DR: GOLD (Genetic Optimisation for Ligand Docking) is an automated ligand docking program that uses a genetic algorithm to explore the full range of ligand conformational flexibility with partial flexibility of the protein, and satisfies the fundamental requirement that the ligand must displace loosely bound water on binding.
Journal Article
Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.
Valerie A. Fadok,Dennis R. Voelker,Priscilla A. Campbell,J. John Cohen,D L Bratton,Peter M. Henson +5 more
TL;DR: The data suggest that macrophages specifically recognize phosphatidylserine that is exposed on the surface of lymphocytes during the development of apoptosis, and suggest that apoptotic lymphocytes lose membrane phospholipid asymmetry and expose phosphorus on the outer leaflet of the plasma membrane.