Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
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TLDR
In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).Abstract:
In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. In either case it is usually assumed in this paper that the lifetime (age at death) is independent of the potential loss time; in practice this assumption deserves careful scrutiny. Despite the resulting incompleteness of the data, it is desired to estimate the proportion P(t) of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t). The observation for each item of a suitable initial event, marking the beginning of its lifetime, is presupposed. For random samples of size N the product-limit (PL) estimate can be defined as follows: L...read more
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Journal ArticleDOI
Cardiovascular Risk Prediction Basic Concepts, Current Status, and Future Directions
TL;DR: A basic review of the history and principles of risk prediction, their statistical underpinnings, and their clinical implications is required to help clinicians and researchers understand the increasingly complex approaches being undertaken to refine CVD risk prediction.
Journal ArticleDOI
Long-Term Survival in Metastatic Transitional-Cell Carcinoma and Prognostic Factors Predicting Outcome of Therapy
Dean F. Bajorin,Paul M. Dodd,Madhu Mazumdar,Melissa Fazzari,John A. McCaffrey,Howard I. Scher,Harry W. Herr,Geralyn Higgins,Mary G. Boyle +8 more
TL;DR: A prognostic factor-based model of survival among patients treated with methotrexate, vinblastine, doxorubicin, and cisplatin chemotherapy could account for differences and help guide clinical trial design and interpretation.
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Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial.
Bernard R. Chaitman,Carl J. Pepine,John O. Parker,Jaroslav Skopal,Galina Chumakova,Jerzy Kuch,Whedy Wang,Sandra L. Skettino,Andrew A. Wolff +8 more
TL;DR: Twice-daily doses of ranolazine increased exercise capacity and provided additional antianginal relief to symptomatic patients with severe chronic angina taking standard doses of atenolol, amlodipine, or diltiazem, without evident adverse, long-term survival consequences.
Book ChapterDOI
Mantle Cell Lymphoma
TL;DR: Mantle cell lymphoma (MCL) is a B-cell neoplasm thought to derive from mantle zone B-cells and characterized by translocations involving the CCND1 gene, most commonly t(11,14),q13,q23 as discussed by the authors.
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Total shoulder arthroplasty with the neer prosthesis: Long-term results
TL;DR: The outcome of 113 total shoulder replacement arthroplasties performed with a Neer prosthesis between 1975 and 1981 for the treatment of osteoarthritis, rheumatoid arthritis, and old fractures or dislocations with traumatic arthritis was determined.
References
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Journal ArticleDOI
Survival Curve for Cancer Patients Following Treatment
Joseph Berkson,Robert P. Gage +1 more
TL;DR: A simple function, in terms of two physically meaningful parameters, has been evolved, which fits survivorship data very well and can be used to compare succinctly the mortality of two groups, different in respect of treatment, type of cancer, or other characteristics.
Journal ArticleDOI
An analysis of some failure data
TL;DR: The rationale and statistical techniques employed in the analysis of some failure data obtained from operations performed by machines and people are summarized and the agreement between theory and data is evaluated.