Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
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TLDR
In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).Abstract:
In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. In either case it is usually assumed in this paper that the lifetime (age at death) is independent of the potential loss time; in practice this assumption deserves careful scrutiny. Despite the resulting incompleteness of the data, it is desired to estimate the proportion P(t) of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t). The observation for each item of a suitable initial event, marking the beginning of its lifetime, is presupposed. For random samples of size N the product-limit (PL) estimate can be defined as follows: L...read more
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Journal ArticleDOI
Follicular Lymphoma International Prognostic Index 2: A New Prognostic Index for Follicular Lymphoma Developed by the International Follicular Lymphoma Prognostic Factor Project
Massimo Federico,Monica Bellei,Luigi Marcheselli,Stefano Luminari,Armando López-Guillermo,Umberto Vitolo,Barbara Pro,Stefano Pileri,Alessandro Pulsoni,Pierre Soubeyran,Sergio Cortelazzo,Giovanni Martinelli,Maurizio Martelli,Luigi Rigacci,Luca Arcaini,Francesco Di Raimondo,Francesco Merli,Elena Sabattini,Peter McLaughlin,Philippe Solal-Celigny +19 more
TL;DR: Follicular Lymphoma International Prognostic Index 2 is a simple prognostic index based on easily available clinical data and may represent a promising new tool for the identification of patients with FL at different risk in the era of immunochemotherapy.
Journal ArticleDOI
Vaccine Prevention of Maternal Cytomegalovirus Infection
Robert F. Pass,Changpin Zhang,Ashley Evans,Tina Simpson,William W. Andrews,Meei Li Huang,Lawrence Corey,Janie Hill,Elizabeth Davis,Cynthia Flanigan,Gretchen A. Cloud +10 more
TL;DR: CMV glycoprotein B vaccine has the potential to decrease incident cases of maternal and congenital CMV infection and was more likely to remain uninfected during a 42-month period than the placebo group.
Journal ArticleDOI
A Phase III Trial of Surgery With or Without Adjunctive External Pelvic Radiation Therapy in Intermediate-Risk Endometrial Adenocarcinoma: A Gynecologic Oncology Group Study
Henry M. Keys,James A. Roberts,Virginia L. Brunetto,Richard J. Zaino,Nick M. Spirtos,Jeffrey D. Bloss,Andrew Pearlman,Mitchell Maiman,Jeffrey Bell +8 more
TL;DR: Adjunctive RT in early stage intermediate risk endometrial carcinoma decreases the risk of recurrence, but should be limited to patients whose risk factors fit a high intermediate risk definition.
Journal ArticleDOI
Clinical Significance of Mitral Regurgitation After Acute Myocardial Infarction
Gervasio A. Lamas,Gary F. Mitchell,Greg C. Flaker,Sidney C. Smith,Bernard J. Gersh,Lofty L. Basta,Lemuel A. Moyé,Eugene Braunwald,Marc A. Pfeffer +8 more
TL;DR: In this article, the authors analyzed left ventriculograms for diastolic and systolic volumes, global left ventricular sphericity, extent of wall motion abnormality, and endocardial curvature and found that the presence of MR was related to the risk of developing a cardiovascular event during 3.5 years of follow-up.
Journal ArticleDOI
Defibrillator implantation early after myocardial infarction.
Gerhard Steinbeck,Dietrich Andresen,K. Seidl,Johannes Brachmann,Ellen Hoffmann,Dariusz Wojciechowski,Zdzisława Kornacewicz-Jach,Beata Sredniawa,Géza Lupkovics,Franz Hofgärtner,Andrzej Lubinski,Mårten Rosenqvist,Alphonsus Habets,Karl Wegscheider,Jochen Senges +14 more
TL;DR: Prophylactic ICD therapy did not reduce overall mortality among patients with acute myocardial infarction and clinical features that placed them at increased risk.
References
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Journal ArticleDOI
Survival Curve for Cancer Patients Following Treatment
Joseph Berkson,Robert P. Gage +1 more
TL;DR: A simple function, in terms of two physically meaningful parameters, has been evolved, which fits survivorship data very well and can be used to compare succinctly the mortality of two groups, different in respect of treatment, type of cancer, or other characteristics.
Journal ArticleDOI
An analysis of some failure data
TL;DR: The rationale and statistical techniques employed in the analysis of some failure data obtained from operations performed by machines and people are summarized and the agreement between theory and data is evaluated.