Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
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TLDR
In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).Abstract:
In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. In either case it is usually assumed in this paper that the lifetime (age at death) is independent of the potential loss time; in practice this assumption deserves careful scrutiny. Despite the resulting incompleteness of the data, it is desired to estimate the proportion P(t) of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t). The observation for each item of a suitable initial event, marking the beginning of its lifetime, is presupposed. For random samples of size N the product-limit (PL) estimate can be defined as follows: L...read more
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The association between hepatitis C infection and survival after orthotopic liver transplantation.
TL;DR: Liver transplantation in HCV-positive recipients was associated with an increased rate of death and allograft failure and this reduction in survival persisted after adjusting for potential confounders.
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Linear regression with censored data
Jonathan Buckley,Ian R. James +1 more
TL;DR: In this paper, a method of estimating parameters in the linear regression model which allows the dependent variable to be censored and the residual distribution to be unspecified is presented, which appears to overcome the inconsistency problems in Miller's approach.
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Multi-Institutional Phase I/II Trial of Stereotactic Body Radiation Therapy for Lung Metastases
Kyle E. Rusthoven,Brian D. Kavanagh,Stuart H. Burri,Changhu Chen,Higinia R. Cardenes,Mark Chidel,Thomas J. Pugh,Madeleine A. Kane,Laurie E. Gaspar,Tracey E. Schefter +9 more
TL;DR: This multi-institutional phase I/II trial demonstrates that high-dose SBRT is safe and effective for the treatment of patients with one to three lung metastases.
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PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma
Paul Nghiem,Shailender Bhatia,Evan J. Lipson,Ragini R. Kudchadkar,Natalie J. Miller,Lakshmanan Annamalai,Sneha Berry,Elliot Chartash,Adil Daud,Steven P. Fling,Philip Friedlander,Harriet M. Kluger,Holbrook E Kohrt,Lisa Lundgren,Kim Margolin,Alan Mitchell,Thomas Olencki,Drew M. Pardoll,Sunil Reddy,E. Shantha,William H. Sharfman,Elad Sharon,Lynn Shemanski,Michi M. Shinohara,Joel C. Sunshine,Janis M. Taube,John A. Thompson,John A. Thompson,Steven M. Townson,Jennifer H. Yearley,Suzanne L. Topalian,Martin A. Cheever,Martin A. Cheever +32 more
TL;DR: First-line therapy with pembrolizumab in patients with advanced Merkel-cell carcinoma was associated with an objective response rate of 56% and effectiveness was correlated with tumor viral status, as assessed by serologic and immunohistochemical testing.
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Prognostic Significance of Histopathologic Subsets in Idiopathic Pulmonary Fibrosis
Julie A. Bjoraker,Jay H. Ryu,Mark K. Edwin,Jeffrey L. Myers,Henry D. Tazelaar,Darrell R. Schroeder,Kenneth P. Offord +6 more
TL;DR: Retrospective analysis of 104 patients with IPF who had open lung biopsy at Mayo Medical Center from 1976 to 1985 was performed to establish the overall survival rate, the spectrum of histopathological subgroups and their associated prognostic significance.
References
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Journal ArticleDOI
Survival Curve for Cancer Patients Following Treatment
Joseph Berkson,Robert P. Gage +1 more
TL;DR: A simple function, in terms of two physically meaningful parameters, has been evolved, which fits survivorship data very well and can be used to compare succinctly the mortality of two groups, different in respect of treatment, type of cancer, or other characteristics.
Journal ArticleDOI
An analysis of some failure data
TL;DR: The rationale and statistical techniques employed in the analysis of some failure data obtained from operations performed by machines and people are summarized and the agreement between theory and data is evaluated.