Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
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In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).Abstract:
In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. In either case it is usually assumed in this paper that the lifetime (age at death) is independent of the potential loss time; in practice this assumption deserves careful scrutiny. Despite the resulting incompleteness of the data, it is desired to estimate the proportion P(t) of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t). The observation for each item of a suitable initial event, marking the beginning of its lifetime, is presupposed. For random samples of size N the product-limit (PL) estimate can be defined as follows: L...read more
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Journal ArticleDOI
Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations.
Anne-Marie Mandard,Frédéric Dalibard,Jean-Claude Mandard,Jacques Marnay,Michel Henry-Amar,Jean-François Petiot,Alain Roussel,Jacques-Henry Jacob,Philippe Segol,Guy Samama,Jean-Marie Ollivier,Sylvie Bonvalot,M. Gignoux +12 more
TL;DR: A pilot study was undertaken to determine if pathologic assessment of tumor regression correlated with disease free survival in patients with esophageal carcinoma.
Journal ArticleDOI
Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes.
Charles J. Yeo,John L. Cameron,Taylor A. Sohn,Keith D. Lillemoe,Henry A. Pitt,Mark A. Talamini,Ralph H. Hruban,Sarah E. Ord,Patricia K. Sauter,Jo Ann Coleman,Marianna Zahurak,Louise B. Grochow,Ross A. Abrams +12 more
TL;DR: This single institution, high-volume experience indicates that pancreaticoduodenectomy can be performed safely for a variety of malignant and benign disorders of the pancreas and periampullary region.
Journal ArticleDOI
Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma
Henry M. Keys,Brian N. Bundy,Frederick B. Stehman,Laila I. Muderspach,Weldon E. Chafe,Charles L. Suggs,Joan L. Walker,Deborah Gersell +7 more
TL;DR: Adding weekly infusions of cisplatin to pelvic radiotherapy followed by hysterectomy significantly reduced the risk of disease recurrence and death in women with bulky stage IB cervical cancers.
Journal ArticleDOI
Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial.
Christopher M. O'Connor,David J. Whellan,David J. Whellan,Kerry L. Lee,Steven J. Keteyian,Lawton S. Cooper,Stephen J. Ellis,Eric S. Leifer,William E. Kraus,Dalane W. Kitzman,James A. Blumenthal,David S. Rendall,Nancy Houston Miller,Jerome L. Fleg,Kevin A. Schulman,Robert S. McKelvie,Faiez Zannad,Ileana L. Piña +17 more
TL;DR: Exercise training was associated with modest significant reductions for both all-cause mortality or hospitalization and cardiovascular mortality or heart failure hospitalization, and in key secondary clinical end points.
Journal ArticleDOI
Treatment of High-Risk Neuroblastoma with Intensive Chemotherapy, Radiotherapy, Autologous Bone Marrow Transplantation, and 13-cis-Retinoic Acid
Katherine K. Matthay,Judith G. Villablanca,Seeger Rc,Daniel O. Stram,Richard E. Harris,Norma K.C. Ramsay,Patrick S. Swift,H. Shimada,C T Black,Garrett M. Brodeur,Robert B. Gerbing,C. P. Reynolds +11 more
TL;DR: Treatment with myeloablative therapy and autologous bone marrow transplantation improved event-free survival among children with high-risk neuroblastoma, and treatment with 13-cis-retinoic acid was beneficial for patients without progressive disease when it was administered after chemotherapy or transplantation.
References
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Journal ArticleDOI
Survival Curve for Cancer Patients Following Treatment
Joseph Berkson,Robert P. Gage +1 more
TL;DR: A simple function, in terms of two physically meaningful parameters, has been evolved, which fits survivorship data very well and can be used to compare succinctly the mortality of two groups, different in respect of treatment, type of cancer, or other characteristics.
Journal ArticleDOI
An analysis of some failure data
TL;DR: The rationale and statistical techniques employed in the analysis of some failure data obtained from operations performed by machines and people are summarized and the agreement between theory and data is evaluated.