Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
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TLDR
In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).Abstract:
In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. In either case it is usually assumed in this paper that the lifetime (age at death) is independent of the potential loss time; in practice this assumption deserves careful scrutiny. Despite the resulting incompleteness of the data, it is desired to estimate the proportion P(t) of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t). The observation for each item of a suitable initial event, marking the beginning of its lifetime, is presupposed. For random samples of size N the product-limit (PL) estimate can be defined as follows: L...read more
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Journal ArticleDOI
Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis.
Merit Cudkowicz,Diane McKenna-Yasek,P. E. Sapp,P. E. Sapp,Wendy Chin,Wendy Chin,Brian A. Geller,Brian A. Geller,Doug Hayden,David A. Schoenfeld,Betsy A. Hosler,H R Horvitz,Robert H. Brown +12 more
TL;DR: Information suggests it will be productive to investigate other genetic determinants in amyotrophic lateral sclerosis and to use epidemiological characteristics of the disease to help discern molecular mechanisms of motor neuron cell death.
Journal ArticleDOI
Canadian Hemodialysis Morbidity Study
David N. Churchill,D. Wayne Taylor,Richard J. Cook,Patricia Laplante,Paul E. Barre,Pierre Cartier,William P. Fay,Marc Goldstein,Kailash Jindal,Henry Mandin,John K. McKenzie,Norman Muirhead,Patrick S. Parfrey,Gerald A. Posen,David Slaughter,Raymond A. Ulan,Ronald Werb +16 more
TL;DR: The objective of this study was to determine the probabilities of specific morbid events or death among patients with end-stage renal disease treated by hemodialysis, and older age and history of cardiovascular disease were independently associated with a greater probability of death.
Journal ArticleDOI
Radiotherapy in breast-conserving treatment for ductal carcinoma in situ: first results of the EORTC randomised phase III trial 10853
J.P. Julien,Nina Bijker,Ian S. Fentiman,Johannes L. Peterse,Vincenzo Delledonne,P. Rouanet,Antoine Avril,Richard Sylvester,Françoise Mignolet,Harry Bartelink,Joop A. van Dongen +10 more
TL;DR: Radiotherapy after local excision for DCIS, as compared with local excison alone, reduced the overall number of both invasive and non-invasive recurrences in the ipsilateral breast at a median follow-up of 4.25 years.
Journal ArticleDOI
The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes.
Momin M. Gabir,Robert L. Hanson,Dana Dabelea,G Imperatore,Janine Roumain,Peter H. Bennett,W. C. Knowler +6 more
TL;DR: The prevalence and incidence of diabetes are somewhat lower with the ADA criteria than with the 1985 or 1999 WHO criteria, and the intermediate categories of glycemia differ substantially, although a smaller number of people who are at higher risk of developing diabetes than those with IGT.
Journal ArticleDOI
Temporal Arteritis: A 25-Year Epidemiologic, Clinical, and Pathologic Study
TL;DR: Among the population of Olmsted County, Minnesota, 42 patients with temporal arteritis were identified during a 25-year period, and the majority of patients recovered fully and were followed off corticosteroids for 10 months to 19 years.
References
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Journal ArticleDOI
Survival Curve for Cancer Patients Following Treatment
Joseph Berkson,Robert P. Gage +1 more
TL;DR: A simple function, in terms of two physically meaningful parameters, has been evolved, which fits survivorship data very well and can be used to compare succinctly the mortality of two groups, different in respect of treatment, type of cancer, or other characteristics.
Journal ArticleDOI
An analysis of some failure data
TL;DR: The rationale and statistical techniques employed in the analysis of some failure data obtained from operations performed by machines and people are summarized and the agreement between theory and data is evaluated.