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Book ChapterDOI

Nonparametric Estimation from Incomplete Observations

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TLDR
In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Abstract
In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. In either case it is usually assumed in this paper that the lifetime (age at death) is independent of the potential loss time; in practice this assumption deserves careful scrutiny. Despite the resulting incompleteness of the data, it is desired to estimate the proportion P(t) of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t). The observation for each item of a suitable initial event, marking the beginning of its lifetime, is presupposed. For random samples of size N the product-limit (PL) estimate can be defined as follows: L...

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Journal ArticleDOI

Primary chemotherapy in operable breast cancer: eight-year experience at the Milan Cancer Institute.

TL;DR: Findings indicate that primary chemotherapy can be safely administered in women with large tumors and can allow breast-sparing surgery in a high fraction of patients and to assess effectively the worthiness of this approach on long-term results, properly conceived large randomized studies with newer and more effective drug regimens are warranted.
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Carcinogenicity of Formaldehyde in Rats and Mice after Long-Term Inhalation Exposure

TL;DR: Rhinitis, epithelial dysplasia, and squamous metaplasia occurred in all exposure groups of rats and in the intermediate and high exposure groups in mice, and formaldehyde inhalation was weakly associated with an increase in the frequency of polypoid adenomas in the nasal cavity of male rats.
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Nephron sparing surgery for localized renal cell carcinoma: impact of tumor size on patient survival, tumor recurrence and TNM staging.

TL;DR: Following nephron sparing surgery for localized sporadic renal cell carcinoma cancer-free survival is significantly better in patients with tumors 4 cm.
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Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease

TL;DR: It is concluded that umbilical cord blood is a sufficient source of transplantable haemopoietic stem cells for children with HLA-identical or Hla-1 antigen disparate sibling donors with very low risk of acute or extensive chronic GVHD.
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Treatment for Primary CNS Lymphoma: The Next Step

TL;DR: Increasing the dose of MTX and adding procarbazine and vincristine improved disease control and overall survival in patients with newly diagnosed PCNSL and younger patients in particular fared extremely well with this treatment regimen.
References
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Journal ArticleDOI

Survival Curve for Cancer Patients Following Treatment

TL;DR: A simple function, in terms of two physically meaningful parameters, has been evolved, which fits survivorship data very well and can be used to compare succinctly the mortality of two groups, different in respect of treatment, type of cancer, or other characteristics.
Journal ArticleDOI

The natural duration of cancer

W. S. Lazarus-Barlow, +1 more
- 16 Aug 1924 - 
Journal ArticleDOI

An analysis of some failure data

TL;DR: The rationale and statistical techniques employed in the analysis of some failure data obtained from operations performed by machines and people are summarized and the agreement between theory and data is evaluated.
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