Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
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TLDR
In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).Abstract:
In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. In either case it is usually assumed in this paper that the lifetime (age at death) is independent of the potential loss time; in practice this assumption deserves careful scrutiny. Despite the resulting incompleteness of the data, it is desired to estimate the proportion P(t) of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t). The observation for each item of a suitable initial event, marking the beginning of its lifetime, is presupposed. For random samples of size N the product-limit (PL) estimate can be defined as follows: L...read more
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Journal ArticleDOI
Primary chemotherapy in operable breast cancer: eight-year experience at the Milan Cancer Institute.
Gianni Bonadonna,Pinuccia Valagussa,Cristina Brambilla,Laura Ferrari,Angela Moliterni,Monica Terenziani,Milvia Zambetti +6 more
TL;DR: Findings indicate that primary chemotherapy can be safely administered in women with large tumors and can allow breast-sparing surgery in a high fraction of patients and to assess effectively the worthiness of this approach on long-term results, properly conceived large randomized studies with newer and more effective drug regimens are warranted.
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Carcinogenicity of Formaldehyde in Rats and Mice after Long-Term Inhalation Exposure
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Nephron sparing surgery for localized renal cell carcinoma: impact of tumor size on patient survival, tumor recurrence and TNM staging.
TL;DR: Following nephron sparing surgery for localized sporadic renal cell carcinoma cancer-free survival is significantly better in patients with tumors 4 cm.
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Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease
TL;DR: It is concluded that umbilical cord blood is a sufficient source of transplantable haemopoietic stem cells for children with HLA-identical or Hla-1 antigen disparate sibling donors with very low risk of acute or extensive chronic GVHD.
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Treatment for Primary CNS Lymphoma: The Next Step
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References
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Journal ArticleDOI
Survival Curve for Cancer Patients Following Treatment
Joseph Berkson,Robert P. Gage +1 more
TL;DR: A simple function, in terms of two physically meaningful parameters, has been evolved, which fits survivorship data very well and can be used to compare succinctly the mortality of two groups, different in respect of treatment, type of cancer, or other characteristics.
Journal ArticleDOI
An analysis of some failure data
TL;DR: The rationale and statistical techniques employed in the analysis of some failure data obtained from operations performed by machines and people are summarized and the agreement between theory and data is evaluated.