Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
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TLDR
In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).Abstract:
In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. In either case it is usually assumed in this paper that the lifetime (age at death) is independent of the potential loss time; in practice this assumption deserves careful scrutiny. Despite the resulting incompleteness of the data, it is desired to estimate the proportion P(t) of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t). The observation for each item of a suitable initial event, marking the beginning of its lifetime, is presupposed. For random samples of size N the product-limit (PL) estimate can be defined as follows: L...read more
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Value of a Doppler-Derived Index Combining Systolic and Diastolic Time Intervals in Predicting Outcome in Primary Pulmonary Hypertension
Tiong Cheng Yeo,Karl S. Dujardin,Chuwa Tei,Douglas W. Mahoney,Michael D. McGoon,James B. Seward +5 more
TL;DR: The results indicate that the Doppler RV index is a useful predictor of adverse outcome in patients with primary pulmonary hypertension, and only the Doppo RV index and treatment with calcium blockers were independent predictors within the multivariate model.
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Comparison in low-tumor-burden follicular lymphomas between an initial no-treatment policy, prednimustine, or interferon alfa: a randomized study from the Groupe d'Etude des Lymphomes Folliculaires. Groupe d'Etude des Lymphomes de l'Adulte
Pauline Brice,Y. Bastion,Eric Lepage,Nicole Brousse,Corinne Haioun,Philippe Moreau,N Straetmans,H. Tilly,I Tabah,Philippe Solal-Celigny +9 more
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Viral Load and Disease Progression in Infants Infected with Human Immunodeficiency Virus Type 1
William T. Shearer,Thomas C. Quinn,Philip LaRussa,Judy F. Lew,Lynne M. Mofenson,Susan Almy,Kenneth C. Rich,Edward Handelsman,Clemente Diaz,Marcello Pagano,Vincent L. Smeriglio,Leslie A. Kalish +11 more
TL;DR: In perinatally infected infants, HIV-1 RNA levels are high and decline only slowly during the first two years of life, which suggests that early treatment with antiretroviral agents may be indicated for these infants.
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Risk factors for acute GVHD and survival after hematopoietic cell transplantation.
Madan Jagasia,Mukta Arora,Mary E.D. Flowers,Nelson J. Chao,Philip L. McCarthy,Corey Cutler,Alvaro Urbano-Ispizua,Steven Z. Pavletic,Michael Haagenson,Mei-Jie Zhang,Joseph H. Antin,Brian J. Bolwell,Christopher Bredeson,Jean-Yves Cahn,Mitchell S. Cairo,Robert Peter Gale,Vikas Gupta,Stephanie J. Lee,Mark R. Litzow,Daniel J. Weisdorf,Mary M. Horowitz,Theresa Hahn +21 more
TL;DR: Conditioning intensity, TBI and graft source have a combined effect on risk of AGVHD that must be considered in deciding on a treatment strategy for individual patients.
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Increased MET Gene Copy Number Negatively Affects Survival of Surgically Resected Non–Small-Cell Lung Cancer Patients
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TL;DR: MET increased gene copy number is an independent negative prognostic factor in surgically resected NSCLC and EGFR gene gain does not impact survival after resection.
References
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Journal ArticleDOI
Survival Curve for Cancer Patients Following Treatment
Joseph Berkson,Robert P. Gage +1 more
TL;DR: A simple function, in terms of two physically meaningful parameters, has been evolved, which fits survivorship data very well and can be used to compare succinctly the mortality of two groups, different in respect of treatment, type of cancer, or other characteristics.
Journal ArticleDOI
An analysis of some failure data
TL;DR: The rationale and statistical techniques employed in the analysis of some failure data obtained from operations performed by machines and people are summarized and the agreement between theory and data is evaluated.