Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
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TLDR
In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).Abstract:
In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. In either case it is usually assumed in this paper that the lifetime (age at death) is independent of the potential loss time; in practice this assumption deserves careful scrutiny. Despite the resulting incompleteness of the data, it is desired to estimate the proportion P(t) of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t). The observation for each item of a suitable initial event, marking the beginning of its lifetime, is presupposed. For random samples of size N the product-limit (PL) estimate can be defined as follows: L...read more
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Journal ArticleDOI
Thalidomide and hematopoietic-cell transplantation for multiple myeloma
Bart Barlogie,Guido Tricot,Elias Anaissie,John D. Shaughnessy,Erik Rasmussen,Frits van Rhee,Athanasios Fassas,Maurizio Zangari,Klaus Hollmig,Mauricio Pineda-Roman,Choon Kee Lee,Giampaolo Talamo,Raymond Thertulien,Elias Kiwan,Somashekar G. Krishna,Michele Fox,John Crowley +16 more
TL;DR: When incorporated into high-dose therapy for myeloma, thalidomide increased the frequency of complete responses and extended event-free survival at the expense of added adverse effects without improving overall survival.
Journal ArticleDOI
Angiographic follow-up after placement of a self-expanding coronary-artery stent.
Patrick W. Serruys,Bradley H. Strauss,Kevin J. Beatt,Michel E. Bertrand,Jacques Puel,Anthony F. Rickards,Bernhard Meier,Jean-Jacques Goy,Pierre Vogt,Lukas Kappenberger,Ulrich Sigwart +10 more
TL;DR: Early occlusion remains an important limitation of this coronary-artery stent and even when the early effects are beneficial, there are frequently late occlusions or restenosis.
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Progesterone Receptor Status Significantly Improves Outcome Prediction Over Estrogen Receptor Status Alone for Adjuvant Endocrine Therapy in Two Large Breast Cancer Databases
TL;DR: When accurately measured, PgR status is an independent predictive factor for benefit from adjuvant endocrine therapy and should be taken into account when discussing RR reductions expected from endocrine treatment with individual patients.
Incidence and prognosis of syncope
S. S Oteriades,J Ane,C. E Vans,M Artin G. L Arson,M Ing,H Ui C Hen,L Eway C Hen,Melia J. B Enjamin,D Aniel L Evy +8 more
Journal ArticleDOI
Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma.
Robert A. Kyle,Ellen D. Remstein,Terry M. Therneau,Angela Dispenzieri,Paul J. Kurtin,Janice M. Hodnefield,Dirk R. Larson,Matthew F. Plevak,Diane F. Jelinek,Rafael Fonseca,Lee Joseph Melton,S. Vincent Rajkumar +11 more
TL;DR: The risk of progression from smoldering multiple myeloma to symptomatic disease is related to the proportion of bone marrow plasma cells and the serum monoclonal protein level at diagnosis.
References
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Journal ArticleDOI
Survival Curve for Cancer Patients Following Treatment
Joseph Berkson,Robert P. Gage +1 more
TL;DR: A simple function, in terms of two physically meaningful parameters, has been evolved, which fits survivorship data very well and can be used to compare succinctly the mortality of two groups, different in respect of treatment, type of cancer, or other characteristics.
Journal ArticleDOI
An analysis of some failure data
TL;DR: The rationale and statistical techniques employed in the analysis of some failure data obtained from operations performed by machines and people are summarized and the agreement between theory and data is evaluated.