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Book ChapterDOI

Nonparametric Estimation from Incomplete Observations

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TLDR
In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Abstract
In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. In either case it is usually assumed in this paper that the lifetime (age at death) is independent of the potential loss time; in practice this assumption deserves careful scrutiny. Despite the resulting incompleteness of the data, it is desired to estimate the proportion P(t) of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t). The observation for each item of a suitable initial event, marking the beginning of its lifetime, is presupposed. For random samples of size N the product-limit (PL) estimate can be defined as follows: L...

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Book

Censoring and stochastic integrals

TL;DR: The second edition of the book as mentioned in this paper is 76 pages longer than the first and has a 50-page appendix entitled, "A Review of Fundamental Concepts" which contains examples and problems from the fields of biology and medicine and unless one is fairly familiar with these subject areas, the example and problems will not be very meaningful.
Journal ArticleDOI

Increased Epidermal Growth Factor Receptor Gene Copy Number Detected by Fluorescence In Situ Hybridization Associates With Increased Sensitivity to Gefitinib in Patients With Bronchioloalveolar Carcinoma Subtypes: A Southwest Oncology Group Study

TL;DR: Increased EGFR gene copy number detected by FISH is associated with improved survival after gefitinib therapy in patients with advanced BAC, suggesting FISH methodology can be used to assess survival potential in patients treated with EGFR tyrosine kinase inhibitors.
Journal ArticleDOI

Clinical Course of Children and Adolescents With Bipolar Spectrum Disorders

TL;DR: Youths with BP spectrum disorders showed a continuum of BP symptom severity from subsyndromal to full syndromal with frequent mood fluctuations, and preliminary validation for BP-NOS is provided.
References
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Journal ArticleDOI

Survival Curve for Cancer Patients Following Treatment

TL;DR: A simple function, in terms of two physically meaningful parameters, has been evolved, which fits survivorship data very well and can be used to compare succinctly the mortality of two groups, different in respect of treatment, type of cancer, or other characteristics.
Journal ArticleDOI

The natural duration of cancer

W. S. Lazarus-Barlow, +1 more
- 16 Aug 1924 - 
Journal ArticleDOI

An analysis of some failure data

TL;DR: The rationale and statistical techniques employed in the analysis of some failure data obtained from operations performed by machines and people are summarized and the agreement between theory and data is evaluated.
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