Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
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TLDR
In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).Abstract:
In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. In either case it is usually assumed in this paper that the lifetime (age at death) is independent of the potential loss time; in practice this assumption deserves careful scrutiny. Despite the resulting incompleteness of the data, it is desired to estimate the proportion P(t) of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t). The observation for each item of a suitable initial event, marking the beginning of its lifetime, is presupposed. For random samples of size N the product-limit (PL) estimate can be defined as follows: L...read more
Citations
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Journal ArticleDOI
Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
Rosalyn A. Juergens,John Wrangle,Frank P. Vendetti,Sara C. Murphy,Ming Zhao,Barbara Coleman,Rosa Sebree,Kristen Rodgers,Craig M. Hooker,Noreli Franco,Beverly Lee,Salina Tsai,Igor Espinoza Delgado,Michelle A. Rudek,Steven A. Belinsky,James G. Herman,Stephen B. Baylin,Malcolm V. Brock,Charles M. Rudin +18 more
TL;DR: It is demonstrated that combined epigenetic therapy with low-dose azacitidine and entinostat results in objective, durable responses in patients with solid tumors and defines a blood-based biomarker that correlates with clinical benefit.
Journal ArticleDOI
Definition of relapse risk and role of nonanthracycline drugs for consolidation in patients with acute promyelocytic leukemia: a joint study of the PETHEMA and GIMEMA cooperative groups.
Miguel A. Sanz,Francesco Lo Coco,Guillermo Martin,Giuseppe Avvisati,Consuelo Rayon,Tiziano Barbui,Joaquín Díaz-Mediavilla,Giuseppe Fioritoni,José D. González,Vincenzo Liso,Jordi Esteve,Felicetto Ferrara,Pascual Bolufer,Carlo Bernasconi,Marcos González,Francesco Rodeghiero,Dolors Colomer,Maria Concetta Petti,José M. Ribera,Franco Mandelli +19 more
TL;DR: The conclusions are that omission of nonanthracycline drugs from the AIDA regimen is not associated with reduced antileukemic efficacy and a simple predictive model may be used for risk-adapted therapy in this disease.
Book
Censoring and stochastic integrals
TL;DR: The second edition of the book as mentioned in this paper is 76 pages longer than the first and has a 50-page appendix entitled, "A Review of Fundamental Concepts" which contains examples and problems from the fields of biology and medicine and unless one is fairly familiar with these subject areas, the example and problems will not be very meaningful.
Journal ArticleDOI
Increased Epidermal Growth Factor Receptor Gene Copy Number Detected by Fluorescence In Situ Hybridization Associates With Increased Sensitivity to Gefitinib in Patients With Bronchioloalveolar Carcinoma Subtypes: A Southwest Oncology Group Study
Fred R. Hirsch,Marileila Varella-Garcia,Jason McCoy,Howard West,Ana Carolina Xavier,Paul H. Gumerlock,Paul A. Bunn,Wilbur A. Franklin,John Crowley,David R. Gandara +9 more
TL;DR: Increased EGFR gene copy number detected by FISH is associated with improved survival after gefitinib therapy in patients with advanced BAC, suggesting FISH methodology can be used to assess survival potential in patients treated with EGFR tyrosine kinase inhibitors.
Journal ArticleDOI
Clinical Course of Children and Adolescents With Bipolar Spectrum Disorders
Boris Birmaher,David Axelson,Michael Strober,Mary Kay Gill,Sylvia Valeri,Laurel Chiappetta,Neal D. Ryan,Henrietta L. Leonard,Jeffrey Hunt,Satish Iyengar,Martin B. Keller +10 more
TL;DR: Youths with BP spectrum disorders showed a continuum of BP symptom severity from subsyndromal to full syndromal with frequent mood fluctuations, and preliminary validation for BP-NOS is provided.
References
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Journal ArticleDOI
Survival Curve for Cancer Patients Following Treatment
Joseph Berkson,Robert P. Gage +1 more
TL;DR: A simple function, in terms of two physically meaningful parameters, has been evolved, which fits survivorship data very well and can be used to compare succinctly the mortality of two groups, different in respect of treatment, type of cancer, or other characteristics.
Journal ArticleDOI
An analysis of some failure data
TL;DR: The rationale and statistical techniques employed in the analysis of some failure data obtained from operations performed by machines and people are summarized and the agreement between theory and data is evaluated.