Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
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TLDR
In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).Abstract:
In lifetesting, medical follow-up, and other fields the observation of the time of occurrence of the event of interest (called a death) may be prevented for some of the items of the sample by the previous occurrence of some other event (called a loss). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. In either case it is usually assumed in this paper that the lifetime (age at death) is independent of the potential loss time; in practice this assumption deserves careful scrutiny. Despite the resulting incompleteness of the data, it is desired to estimate the proportion P(t) of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t). The observation for each item of a suitable initial event, marking the beginning of its lifetime, is presupposed. For random samples of size N the product-limit (PL) estimate can be defined as follows: L...read more
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Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies
Ranjana H. Advani,Joseph J. Buggy,Jeff P. Sharman,Sonali M. Smith,Thomas E. Boyd,Barbara Grant,Kathryn S. Kolibaba,Richard R. Furman,Sara Rodriguez,Betty Y. Chang,Juthamas Sukbuntherng,Raquel Izumi,Ahmed Hamdy,Eric Hedrick,Nathan Fowler +14 more
TL;DR: Ibrutinib, a novel BTK-targeting inhibitor, is well tolerated, with substantial activity across B-cell histologies, consistent with the irreversible mechanism.
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Incidence and prognosis of syncope
Elpidoforos S. Soteriades,Jane C. Evans,Martin G. Larson,Ming-Hui Chen,Leway Chen,Emelia J. Benjamin,Daniel Levy +6 more
TL;DR: The incidence, specific causes, and prognosis of syncope among women and men participating in the Framingham Heart Study from 1971 to 1998 were evaluated and the most frequently identified causes were vasovagal, cardiac, and orthostatic.
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Weight Loss Is a Reversible Factor in the Prognosis of Chronic Obstructive Pulmonary Disease
TL;DR: The objective of the study was to further unravel the prognostic significance of body weight changes in patients with COPD and to quantify the relationship between the baseline ...
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Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease: Thorax 2005;60:925–31
Juan José Soler-Cataluña,Miguel Ángel Martínez-García,P Román Sánchez,E Salcedo,Miriam Navarro,R Ochando +5 more
TL;DR: This study shows for the first time that severe acute exacerbations of COPD have an independent negative impact on patient prognosis, particularly if these require admission to hospital.
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Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival.
John E. Wagner,Juliet N. Barker,Todd E. DeFor,K. Scott Baker,Bruce R. Blazar,Cindy R. Eide,Anne I. Goldman,John H. Kersey,William Krivit,Margaret L. MacMillan,Paul J. Orchard,Charles Peters,Daniel J. Weisdorf,Norma K.C. Ramsay,Stella M. Davies +14 more
TL;DR: There is a high probability of survival in recipients of UCB grafts that are disparate in no more than 2 human leukocyte antigens when the grafts contain at least 1.7 x 10(5) CD34(+) cells per kilogram of recipient's body weight, and graft selection should be based principally on CD34 cell dose when multiple UCB units exist with an HLA disparity of 2 or less.
References
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Journal ArticleDOI
Survival Curve for Cancer Patients Following Treatment
Joseph Berkson,Robert P. Gage +1 more
TL;DR: A simple function, in terms of two physically meaningful parameters, has been evolved, which fits survivorship data very well and can be used to compare succinctly the mortality of two groups, different in respect of treatment, type of cancer, or other characteristics.
Journal ArticleDOI
An analysis of some failure data
TL;DR: The rationale and statistical techniques employed in the analysis of some failure data obtained from operations performed by machines and people are summarized and the agreement between theory and data is evaluated.