Journal ArticleDOI
Overlooking the obvious? On the potential of treatment alterations to predict patient-specific therapy response.
Ingo Roeder,Ingmar Glauche +1 more
TLDR
The full potential of using the available information on disease and treatment dynamics in the context of outcome prediction or individualized treatment optimization still seems to be - at least partially - overlooked.About:
This article is published in Experimental Hematology.The article was published on 2021-02-01. It has received 5 citations till now.read more
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Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy
moenusupau,Jamshid Razmyar +1 more
TL;DR: In this paper , a nonlinear mathematical model of CML hematopoiesis was developed that incorporates feedback control and lineage branching, and the model predicts that stimulating the differentiation of leukemic stem cells while applying TKI therapy can significantly improve treatment outcomes.
Journal ArticleDOI
Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy
TL;DR: In this paper , a nonlinear mathematical model of CML hematopoiesis was developed to predict the efficacy of TKI treatment and design strategies to improve treatment response.
Journal ArticleDOI
How to predict relapse in leukemia using time series data: A comparative in silico study.
Helene Hoffmann,Christoph Baldow,Thomas Zerjatke,Andrea Gottschalk,Sebastian Wagner,Elena Karg,Sebastian Niehaus,Ingo Roeder,Ingmar Glauche,Nico Scherf +9 more
TL;DR: In this paper, the authors compared three different computational methods, namely mechanistic models, generalized linear models, and deep neural networks that have been fitted to the reference data, and found that data quality has a higher impact on prediction accuracy than the specific choice of the particular method.
Posted ContentDOI
How to predict relapse in leukaemia using time series data: A comparative in silico study.
Helene Hoffmann,Christoph Baldow,Thomas Zerjatke,Andrea Gottschalk,Sebastian Wagner,Elena Karg,Sebastian Niehaus,Ingo Roeder,Ingmar Glauche,Nico Scherf +9 more
TL;DR: This proof-of-principle study highlights how computational methods and optimized data acquisition strategies can improve risk assessment and treatment of leukaemia patients and finds that data quality has a higher impact on prediction accuracy than the specific choice of the method.
Journal ArticleDOI
Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy
Jonathan Rodriguez,Abdon Iniguez,Nilamani Jena,Prasanthi V. Tata,Joan Liu,Arthur D. Lander,John Lowengrub,Richard A. Van Etten +7 more
TL;DR: A nonlinear mathematical model of CML hematopoiesis that incorporates feedback control and lineage branching is developed and suggests that stimulating the differentiation of leukemic stem cells while applying TKI therapy can significantly improve treatment outcomes.
References
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The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
Daniel A. Arber,Attilio Orazi,Robert P. Hasserjian,Jürgen Thiele,Michael J. Borowitz,Michelle M. Le Beau,Clara D. Bloomfield,Mario Cazzola,James W. Vardiman +8 more
TL;DR: The 2016 edition of the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues represents a revision of the prior classification rather than an entirely new classification and attempts to incorporate new clinical, prognostic, morphologic, immunophenotypic, and genetic data that have emerged since the last edition.
Journal ArticleDOI
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
Siddhartha Jaiswal,Pierre Fontanillas,Jason Flannick,Jason Flannick,Alisa K. Manning,Peter V. Grauman,Brenton G. Mar,Brenton G. Mar,R. Coleman Lindsley,Craig H. Mermel,Noël P. Burtt,Alejandro Chavez,John M. Higgins,Vladislav Moltchanov,Vladislav Moltchanov,Frank C. Kuo,Michael J. Kluk,Brian E. Henderson,Leena Kinnunen,Heikki A. Koistinen,Heikki A. Koistinen,Claes Ladenvall,Gad Getz,Adolfo Correa,Benjamin F. Banahan,Stacey Gabriel,Stacey Gabriel,Sekar Kathiresan,Heather M. Stringham,Mark I. McCarthy,Michael Boehnke,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Christopher A. Haiman,Leif Groop,Gil Atzmon,James G. Wilson,Donna Neuberg,David Altshuler,Benjamin L. Ebert +40 more
TL;DR: Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly due to an increased risk of cardiovascular disease.
Journal ArticleDOI
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
Giulio Genovese,Anna K. Kähler,Robert E. Handsaker,Johan Lindberg,Samuel A. Rose,Samuel F. Bakhoum,Kimberly Chambert,Eran Mick,Benjamin M. Neale,Menachem Fromer,Shaun Purcell,Oscar Svantesson,Mikael Landén,Martin Höglund,Sören Lehmann,Stacey Gabriel,Jennifer L. Moran,Eric S. Lander,Patrick F. Sullivan,Pamela Sklar,Henrik Grönberg,Christina M. Hultman,Steven A. McCarroll +22 more
TL;DR: Clonal hematopoiesis with somatic mutations is readily detected by means of DNA sequencing, is increasingly common as people age, and is associated with increased risks of hematologic cancer and death.
Journal ArticleDOI
The origin and evolution of mutations in acute myeloid leukemia.
John S. Welch,Timothy J. Ley,Daniel C. Link,Christopher A. Miller,David E. Larson,Daniel C. Koboldt,Lukas D. Wartman,Tamara Lamprecht,Fulu Liu,Jun Xia,Cyriac Kandoth,Robert S. Fulton,Michael D. McLellan,David J. Dooling,John W. Wallis,Ken Chen,Chris Harris,Heather Schmidt,Joelle Kalicki-Veizer,Charles Lu,Qunyuan Zhang,Ling Lin,Michelle O'Laughlin,Joshua F. McMichael,Kim D. Delehaunty,Lucinda Fulton,Vincent Magrini,Sean McGrath,Ryan Demeter,Tammi L. Vickery,Jasreet Hundal,Lisa Cook,Gary W. Swift,Jerry P. Reed,Patricia A. Alldredge,Todd Wylie,Jason Walker,Mark A. Watson,Sharon Heath,William D. Shannon,Nobish Varghese,Rakesh Nagarajan,Jacqueline E. Payton,Jack Baty,Shashikant Kulkarni,Jeffery M. Klco,Michael H. Tomasson,Peter Westervelt,Matthew J. Walter,Timothy A. Graubert,John F. DiPersio,Li Ding,Elaine R. Mardis,Richard K. Wilson +53 more
TL;DR: The data suggest that most of the mutations found in AML genomes are actually random events that occurred in HSPCs before they acquired the initiating mutation; the mutational history of that cell is "captured" as the clone expands.
Journal ArticleDOI
Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial
Francois-Xavier Mahon,Delphine Rea,Joelle Guilhot,François Guilhot,Françoise Huguet,Franck E. Nicolini,Laurence Legros,Aude Charbonnier,Agnès Guerci,Bruno Varet,Gabriel Etienne,Josy Reiffers,Philippe Rousselot +12 more
TL;DR: Imatinib discontinuation in this setting yields promising results for molecular relapse-free survival, raising the possibility that, at least in some patients, CML might be cured with tyrosine kinase inhibitors.