Personality and risk of Alzheimer's disease: New data and meta-analysis
Antonio Terracciano,Antonio Terracciano,Angelina R. Sutin,Angelina R. Sutin,Yang An,Richard O'Brien,Luigi Ferrucci,Alan B. Zonderman,Susan M. Resnick +8 more
TLDR
Whether broad factors and specific facets of personality are associated with increased risk of incident Alzheimer's disease in a long‐run longitudinal study and a meta‐analysis of published studies is examined.Abstract:
Background We examine whether broad factors and specific facets of personality are associated with increased risk of incident Alzheimer's disease (AD) in a long-run longitudinal study and a meta-analysis of published studies. Methods Participants (n = 1671) were monitored for up to 22 years from a baseline personality assessment. The meta-analysis pooled results from up to five prospective studies (n = 5054). Results Individuals with scores in the top quartile of neuroticism (hazard ratio=3.1; 95% confidence interval=1.6–6.0) or the lowest quartile of conscientiousness (hazard ratio = 3.3; 95% confidence interval=1.4–7.4) had a threefold increased risk of incident AD. Among the components of these traits, self-discipline and depression had the strongest associations with incident AD. The meta-analysis confirmed the associations of neuroticism ( P = 2 × 10 −9 ) and conscientiousness ( P = 2 × 10 −6 ), along with weaker effects for openness and agreeableness ( P Conclusions The current study and meta-analysis indicate that personality traits are associated with increased risk of AD, with effect sizes similar to those of well-established clinical and lifestyle risk factors.read more
Citations
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Meta-analysis of modifiable risk factors for Alzheimer's disease
Wei Xu,Lan Tan,Hui-Fu Wang,Teng Jiang,Meng-Shan Tan,Lin Tan,Qing-Fei Zhao,Jie-Qiong Li,Jun Wang,Jin-Tai Yu +9 more
TL;DR: Effective interventions in diet, medications, biochemical exposures, psychological condition, pre-existing disease and lifestyle may decrease new incidence of AD.
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Implementation of subjective cognitive decline criteria in research studies.
José Luis Molinuevo,Laura A. Rabin,Laura A. Rabin,Rebecca E. Amariglio,Rachel F. Buckley,Rachel F. Buckley,Rachel F. Buckley,Bruno Dubois,Kathryn A. Ellis,Michael Ewers,Harald Hampel,Harald Hampel,Stefan Klöppel,Lorena Rami,Barry Reisberg,Andrew J. Saykin,Sietske A.M. Sikkes,Colette M. Smart,Beth E. Snitz,Reisa A. Sperling,Wiesje M. van der Flier,Michael Wagner,Frank Jessen +22 more
TL;DR: In this article, the Subjective Cognitive Decline Initiative (SCD-I) published research criteria in the context of preclinical AD, with the aim of harmonization of SCD measurement across studies to enhance comparability and generalizability across studies.
Journal ArticleDOI
Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder
Marleen H. M. de Moor,Stéphanie Martine van den Berg,Karin J. H. Verweij,Karin J. H. Verweij,Robert F. Krueger,Michelle Luciano,Alejandro Arias Vasquez,Lindsay K. Matteson,Jaime Derringer,Tõnu Esko,Najaf Amin,Scott D. Gordon,Narelle K. Hansell,Amy B. Hart,Ilkka Seppälä,Jennifer E. Huffman,Bettina Konte,Jari Lahti,Minyoung Lee,Michael B. Miller,Teresa Nutile,Toshiko Tanaka,Alexander Teumer,Alexander Viktorin,Juho Wedenoja,Gonçalo R. Abecasis,Daniel E. Adkins,Arpana Agrawal,Jüri Allik,Jüri Allik,Katja Appel,Timothy B. Bigdeli,Fabio Busonero,Harry Campbell,Paul T. Costa,George Davey Smith,Gail Davies,Harriet de Wit,Jun Ding,Barbara E. Engelhardt,Johan G. Eriksson,Iryna O. Fedko,Luigi Ferrucci,Barbara Franke,Ina Giegling,Richard A. Grucza,Annette M. Hartmann,Andrew C. Heath,Kati Heinonen,Anjali K. Henders,Georg Homuth,Jouke-Jan Hottenga,William G. Iacono,Joost G. E. Janzing,Markus Jokela,Robert Karlsson,John P. Kemp,John P. Kemp,Matthew G. Kirkpatrick,Antti Latvala,Antti Latvala,Terho Lehtimäki,David C. Liewald,Pamela A. F. Madden,Chiara Magri,Patrik K. E. Magnusson,Jonathan Marten,Andrea Maschio,Sarah E. Medland,Evelin Mihailov,Yuri Milaneschi,Grant W. Montgomery,Matthias Nauck,Klaasjan G. Ouwens,Aarno Palotie,Aarno Palotie,Erik Pettersson,Ozren Polasek,Yong Qian,Laura Pulkki-Råback,Olli T. Raitakari,Anu Realo,Richard J. Rose,Daniela Ruggiero,Carsten Oliver Schmidt,Wendy S. Slutske,Rossella Sorice,John M. Starr,Beate St Pourcain,Angelina R. Sutin,Angelina R. Sutin,Nicholas J. Timpson,Holly Trochet,Sita H. Vermeulen,Eero Vuoksimaa,Elisabeth Widen,Jasper Wouda,Jasper Wouda,Margaret J. Wright,Lina Zgaga,Lina Zgaga,David J. Porteous,Alessandra Minelli,Abraham A. Palmer,Dan Rujescu,Marina Ciullo,Caroline Hayward,Igor Rudan,Andres Metspalu,Jaakko Kaprio,Jaakko Kaprio,Ian J. Deary,Katri Räikkönen,James F. Wilson,Liisa Keltikangas-Järvinen,Laura J. Bierut,John M. Hettema,Hans Joergen Grabe,Cornelia M. van Duijn,David M. Evans,David M. Evans,David Schlessinger,N. L. Pedersen,Antonio Terracciano,Matt McGue,Matt McGue,Brenda W.J.H. Penninx,Nicholas G. Martin,Dorret I. Boomsma +128 more
TL;DR: This study identifies a novel locus for neuroticism located in a known gene that has been associated with bipolar disorder and schizophrenia in previous studies and shows that neuroticism is influenced by many genetic variants of small effect that are either common or tagged by common variants.
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Does personality predict health and well-being? A metasynthesis.
TL;DR: This metasynthesis provides among the most compelling evidence to date that personality predicts overall health and well-being and may inform research on the mechanisms by which personality impacts health as well asResearch on the structure of personality.
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