Journal ArticleDOI
Preliminary Single-Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial.
Mariusz Bral,Boris Gala-Lopez,David L. Bigam,Norman M. Kneteman,Andrew J. Malcolm,Scott Livingstone,Axel Andres,Juliet Emamaullee,Leslie James Russell,Constantin C. Coussios,Lori J. West,Peter J. Friend,A. M. J. Shapiro +12 more
TLDR
A preliminary single‐center North American experience using identical NMP technology demonstrates feasibility as well as potential technical risks of NMP in a North American setting and highlights a need for larger, randomized studies.About:
This article is published in American Journal of Transplantation.The article was published on 2017-04-01. It has received 170 citations till now. The article focuses on the topics: Liver function & Liver transplantation.read more
Citations
More filters
Journal ArticleDOI
Maschinenperfusion in der Lebertransplantation – was ist möglich und wo stehen wir in Deutschland? Übersicht der Literatur und Ergebnisse einer nationalen Umfrage
Felix Oldhafer,Oliver Beetz,Sebastian Cammann,N. Richter,Juergen Klempnauer,Florian W. R. Vondran +5 more
TL;DR: The hypotherme maschinenperfusion (HMP) as discussed by the authors is one of the most widely used methods in the world for transplanting organs in the Lebertransplantation.
Journal ArticleDOI
Machine Preservation of the Liver: What Is the Future Holding?
TL;DR: Different groups in Europe and North America have translated the laboratory practice into human trials demonstrating promising improvements on hepatic injury and liver function, and current research is focused on optimizing the perfusion settings, developing assessment parameters for graft injury and function during perfusion.
Journal ArticleDOI
Effects of Short-Term Normothermic and Subnormothermic Perfusion After Cold Preservation on Liver Transplantation From Donors After Cardiac Death.
Shuhei Yamada,Shigehito Miyagi,Yasuyuki Hara,Yuta Kakizaki,Hideaki Sasajima,Kazuhiro Mitsui,Keisei Fujimori,Michiaki Unno,Takashi Kamei,Masafumi Goto +9 more
TL;DR: SELP rescued DCD livers from ischemia-reperfusion injury the same as the normothermic perfusion before or after CS groups; hence, this technique may increase the organ pool.
Journal ArticleDOI
Development of an automated liver perfusion system: The benefit of a hemofilter.
Lucía Gullón,Judit Gutiérrez-Gutiérrez,Judit Gutiérrez-Gutiérrez,Robert T Sánchez del Arco,Robert T Sánchez del Arco,Andrés Rivera,Andrés Rivera,Ignacio Gonzalez Fernandez,Ignacio Gonzalez Fernandez,Juan F. Del Cañizo +9 more
TL;DR: The developed hardware and software are subjected to further tuning for additional purposes such as pathophysiologic studies, suboptimal grafts recovery, or recellularization of decellularized scaffolds among others.
Journal ArticleDOI
Where are We Today with Machine Perfusion of Liver in Donation after Circulatory Death Liver Transplantation?
TL;DR: In this paper , a review focused on the data from clinical trials and studies in human liver transplantation after circulatory death (DCD) has been conducted, where ex vivo machine perfusion of the donor liver in DCD LT was used.
References
More filters
Journal ArticleDOI
Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.
TL;DR: The new complication classification appears reliable and may represent a compelling tool for quality assessment in surgery in all parts of the world.
Journal ArticleDOI
Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
Kim M. Olthoff,Laura Kulik,Benjamin Samstein,Mary Kaminski,Michael Abecassis,Jean C. Emond,Abraham Shaked,Jason D. Christie +7 more
TL;DR: A simple definition of EAD using objective posttransplant criteria identified a 23% incidence, and was highly associated with graft loss and patient mortality, validating previously published criteria.
Journal ArticleDOI
Hypothermic Machine Preservation in Human Liver Transplantation: The First Clinical Series
James V. Guarrera,Scot D. Henry,Benjamin Samstein,R. Odeh‐Ramadan,M. Kinkhabwala,Michael J. Goldstein,Lloyd E. Ratner,John F. Renz,H. T. Lee,Robert S. Brown,Jean C. Emond +10 more
TL;DR: HMP of donor livers provided safe and reliable preservation in this pilot case‐controlled series and further multicenter HMP trials are now warranted.
Journal ArticleDOI
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
R. Ravikumar,Wayel Jassem,Hynek Mergental,Nigel Heaton,Darius F. Mirza,M. T. P. R. Perera,Alberto Quaglia,David Holroyd,Thomas Vogel,Constantin C. Coussios,Peter J. Friend +10 more
TL;DR: This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation, and may be valuable in increasing the number of donor livers and improving the function of transplantable organs.
Journal ArticleDOI
Liver Transplantation Using Donation After Cardiac Death Donors: Long-Term Follow-Up from a Single Center
M. E. de Vera,R Lopez-Solis,Igor Dvorchik,S Campos,W Morris,Anthony J. Demetris,Paulo Fontes,J. W. Marsh +7 more
TL;DR: There was a lack of survival benefit in DCD livers utilized in patients with model for end‐stage liver disease (MELD) ≤30 or those not on organ‐perfusion support, as graft survival was significantly lower compared to DBD patients, however, DCD and DBD subjects transplanted with MELD >30 or on organ-perfusions support had similar graft survival, suggesting a potentially greater benefit of DCDLivers in critically ill patients.
Related Papers (5)
A randomized trial of normothermic preservation in liver transplantation
D Nasralla,Constantin C. Coussios,Hynek Mergental,M. Zeeshan Akhtar,Andrew J. Butler,Carlo D L Ceresa,Virginia Chiocchia,Susan J Dutton,Juan Carlos García-Valdecasas,Nigel Heaton,Charles Imber,Wayel Jassem,Ina Jochmans,John Karani,Simon R. Knight,Simon R. Knight,Peri Kocabayoglu,Massimo Malagó,Darius F. Mirza,Peter J. Morris,Peter J. Morris,Arvind Pallan,Andreas Paul,Mihai Pavel,M. Thamara P. R. Perera,Jacques Pirenne,R. Ravikumar,Leslie James Russell,Sara Upponi,Christopher J.E. Watson,Annemarie Weissenbacher,Rutger J. Ploeg,Peter J. Friend +32 more