Journal ArticleDOI
Preliminary Single-Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial.
Mariusz Bral,Boris Gala-Lopez,David L. Bigam,Norman M. Kneteman,Andrew J. Malcolm,Scott Livingstone,Axel Andres,Juliet Emamaullee,Leslie James Russell,Constantin C. Coussios,Lori J. West,Peter J. Friend,A. M. J. Shapiro +12 more
TLDR
A preliminary single‐center North American experience using identical NMP technology demonstrates feasibility as well as potential technical risks of NMP in a North American setting and highlights a need for larger, randomized studies.About:
This article is published in American Journal of Transplantation.The article was published on 2017-04-01. It has received 170 citations till now. The article focuses on the topics: Liver function & Liver transplantation.read more
Citations
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Journal ArticleDOI
Observations on the ex situ perfusion of livers for transplantation.
Christopher J.E. Watson,Vasilis Kosmoliaptsis,Caitlin Pley,Lucy V. Randle,Corinna Fear,Keziah Crick,Alexander Gimson,Michael Allison,Sara Upponi,Rebecca Brais,Ina Jochmans,Andrew J. Butler +11 more
TL;DR: Evaluation of bile pH may offer a valuable insight into bile duct integrity and risk of posttransplant ischemic cholangiopathy, as well as a combination of transaminase release, glucose metabolism, lactate clearance, and maintenance of acid‐base balance.
Journal ArticleDOI
Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial
Rianne van Rijn,Ivo J. Schurink,Yvonne de Vries,Aad P. van den Berg,Miriam Cortes Cerisuelo,Sarwa Darwish Murad,Joris I. Erdmann,Nicholas Gilbo,Robbert J. de Haas,Nigel Heaton,Bart van Hoek,Volkert A.L. Huurman,Ina Jochmans,Otto B. van Leeuwen,Vincent E de Meijer,D. Monbaliu,W.G. Polak,Jules J.G. Slangen,Roberto I. Troisi,Aude Vanlander,Jeroen de Jonge,Robert J. Porte +21 more
TL;DR: In this article, the authors showed that liver transplantation after circulatory death is associated with an increased risk of nonanastomotic biliary strictures and hypothermic oxygenated machine (HOMEM) was used to treat the strictures.
Journal ArticleDOI
Outcomes of DCD liver transplantation using organs treated by hypothermic oxygenated perfusion before implantation
Andrea Schlegel,Andrea Schlegel,Xavier Muller,Marit Kalisvaart,Beat Muellhaupt,M. Thamara P. R. Perera,John Isaac,Pierre-Alain Clavien,Paolo Muiesan,Philipp Dutkowski +9 more
TL;DR: 5-year graft survival in donation after cardiac death livers treated by conventional cold storage, or by 1-2 h of hypothermic oxygenated perfusion (HOPE) after cold storage suggests that a simple end-ischaemic perfusion approach is very effective and may open the field for safe utilisation of extended DCD liver grafts.
Journal ArticleDOI
Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation.
Amelia J. Hessheimer,Elisabeth Coll,Ferran Torres,Patricia Ruiz,Mikel Gastaca,José Ignacio Rivas,Manuel Gómez,B. Sanchez,Julio Santoyo,Pablo Ramírez,Pascual Parrilla,Luis Miguel Marín,Miguel Ángel Gómez-Bravo,Juan Carlos García-Valdecasas,Javier López-Monclús,Andrea Boscá,Rafael López-Andújar,Jiliam Fundora-Suárez,Jesús Villar,Álvaro García-Sesma,Carlos Jiménez,G. Rodriguez-Laiz,Laura Lladó,Juan Carlos Rodríguez,Manuel Barrera,Ramón Charco,Jose Ángel López-Baena,Javier Briceño,Fernando Pardo,Gerardo Blanco,David Pacheco,Beatriz Domínguez-Gil,Víctor Sánchez Turrión,Constantino Fondevila +33 more
TL;DR: The study results suggest that the use of postmortem normothermic regional perfusion helps reduce rates of post-transplant biliary complications and graft loss and allows for the successful transplantation of livers from older cDCD donors of advanced age.
Journal ArticleDOI
Novel Real-time Prediction of Liver Graft Function During Hypothermic Oxygenated Machine Perfusion Before Liver Transplantation
Xavier Muller,Andrea Schlegel,Philipp Kron,Dilmurodjon Eshmuminov,Michael Würdinger,David Meierhofer,Pierre-Alain Clavien,Philipp Dutkowski +7 more
TL;DR: Assessment of flavin, a marker of mitochondrial complex I injury, in the perfusate provides a fast prediction of liver graft function and loss during ex situ MP before implantation, which may have high clinical relevance, as liver grafts from extended DBD or DCD donors carry considerable risks for recipients.
References
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Journal ArticleDOI
Controlled Oxygenated Rewarming of Cold Stored Livers Prior to Transplantation: First Clinical Application of a New Concept.
Dieter P. Hoyer,Zoltan Mathe,Anja Gallinat,Ali C. Canbay,Juergen Treckmann,Ursula Rauen,Andreas Paul,Thomas Minor +7 more
TL;DR: This first clinical application suggests that controlled graft rewarming after cold storage is a feasible and safe method in clinical praxis and might become an adjunct in organ preservation.
Journal ArticleDOI
Sanguineous normothermic machine perfusion improves hemodynamics and biliary epithelial regeneration in donation after cardiac death porcine livers
Qiang Liu,Ahmed Nassar,Kevin Farias,Laura D. Buccini,William M. Baldwin,Martin J. Mangino,Ana E. Bennett,Colin O'Rourke,Toshiro Okamoto,Teresa Diago Uso,John J. Fung,Kareem Abu-Elmagd,Charles Miller,Cristiano Quintini +13 more
TL;DR: In this paper, the effects of normothermic machine perfusion (NMP) on the postreperfusion hemodynamics and extrahepatic biliary duct histology of donation after cardiac death (DCD) livers after transplantation have not been addressed thoroughly and represent the objective of this study.
Journal ArticleDOI
The role of normothermic extracorporeal perfusion in minimizing ischemia reperfusion injury
TL;DR: Normothermic machine perfusion might transpire to be the ideal vehicle to deliver other therapeutic interventions during preservation to modulate and optimize the graft before transplantation by restoring function in marginal donor organs and enabling the clinician to appraise its viability, the donor pool might be greatly expanded.
Journal ArticleDOI
Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation.
R. Cursio,Jean Gugenheim +1 more
TL;DR: The risk factors and mechanisms leading to ITBLs following LT are reviewed, including Liver grafts from suboptimal or extended-criteria donors are more susceptible to cold and warm I-R injury and develop more easilyITBLs than normal livers.
Journal ArticleDOI
Protection of bile ducts in liver transplantation: looking beyond ischemia.
TL;DR: Current and emerging insight in the pathogenesis of NAS and potential targets to reduce biliary injury and preserve bile ducts are discussed in this overview.
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