Journal ArticleDOI
Preliminary Single-Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial.
Mariusz Bral,Boris Gala-Lopez,David L. Bigam,Norman M. Kneteman,Andrew J. Malcolm,Scott Livingstone,Axel Andres,Juliet Emamaullee,Leslie James Russell,Constantin C. Coussios,Lori J. West,Peter J. Friend,A. M. J. Shapiro +12 more
TLDR
A preliminary single‐center North American experience using identical NMP technology demonstrates feasibility as well as potential technical risks of NMP in a North American setting and highlights a need for larger, randomized studies.About:
This article is published in American Journal of Transplantation.The article was published on 2017-04-01. It has received 170 citations till now. The article focuses on the topics: Liver function & Liver transplantation.read more
Citations
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Journal ArticleDOI
Recent advances in the field of warm ex-vivo liver perfusion.
Dagmar Kollmann,Markus Selzner +1 more
TL;DR: The present review summarizes the advances in the field of warm ex-vivo liver perfusion over the last 12 months and highlights new strategies for graft assessment and modification during machine perfusion that have been evaluated with promising results.
Journal ArticleDOI
Production of Physiologically Relevant Quantities of Hemostatic Proteins During Ex Situ Normothermic Machine Perfusion of Human Livers
Shanice A. Karangwa,Jelle Adelmeijer,Alix P M Matton,Vincent E de Meijer,Ton Lisman,Robert J. Porte +5 more
TL;DR: Ex-situ normothermic machine perfusion of donor livers is an emerging innovation in liver transplantation that has made its transition to clinical trials and the perfusion fluids used in NMP studies are composed of either plasma-based solutions or plasma-free solutions consisting of colloids such as Gelofusine1.
Journal ArticleDOI
Split-Liver Ex Situ Machine Perfusion: A Novel Technique for Studying Organ Preservation and Therapeutic Interventions.
Viola Huang,Negin Karimian,Danielle Detelich,Siavash Raigani,Sharon Geerts,Irene Beijert,Fermin Fontan,Mohamed M. Aburawi,Sinan Ozer,Peony D. Banik,Florence Lin,Murat Karabacak,Ehab O A Hafiz,Robert J. Porte,Korkut Uygun,James F. Markmann,Heidi Yeh +16 more
TL;DR: A split-liver perfusion model was developed to allow simultaneous perfusion of left and right lobes, allowing one lobe to serve as a control for the other, and exhibited a progressive decrease in arterial resistance and lactate levels throughout perfusion.
Journal ArticleDOI
Donation after Circulatory Death in Paediatric Liver Transplantation: Current Status and Future Perspectives in the Machine Perfusion Era.
Roberta Angelico,M. Thamara P. R. Perera,Tommaso Maria Manzia,Alessandro Parente,Chiara Grimaldi,Marco Spada +5 more
TL;DR: Current literature on DCD liver grafts transplanted in children and on the use of extracorporeal donor support and liver perfusion machines in paediatrics are reviewed with the aim of defining the current status and future perspectives of paediatric LT.
Journal ArticleDOI
Liver graft preservation methods during cold ischemia phase and normothermic machine perfusion.
TL;DR: Normothermic machine perfusion may help to estimate graft functionality before implantation into a recipient, and NMP is actively evaluating promising method for this purpose.
References
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Journal ArticleDOI
Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.
TL;DR: The new complication classification appears reliable and may represent a compelling tool for quality assessment in surgery in all parts of the world.
Journal ArticleDOI
Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
Kim M. Olthoff,Laura Kulik,Benjamin Samstein,Mary Kaminski,Michael Abecassis,Jean C. Emond,Abraham Shaked,Jason D. Christie +7 more
TL;DR: A simple definition of EAD using objective posttransplant criteria identified a 23% incidence, and was highly associated with graft loss and patient mortality, validating previously published criteria.
Journal ArticleDOI
Hypothermic Machine Preservation in Human Liver Transplantation: The First Clinical Series
James V. Guarrera,Scot D. Henry,Benjamin Samstein,R. Odeh‐Ramadan,M. Kinkhabwala,Michael J. Goldstein,Lloyd E. Ratner,John F. Renz,H. T. Lee,Robert S. Brown,Jean C. Emond +10 more
TL;DR: HMP of donor livers provided safe and reliable preservation in this pilot case‐controlled series and further multicenter HMP trials are now warranted.
Journal ArticleDOI
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
R. Ravikumar,Wayel Jassem,Hynek Mergental,Nigel Heaton,Darius F. Mirza,M. T. P. R. Perera,Alberto Quaglia,David Holroyd,Thomas Vogel,Constantin C. Coussios,Peter J. Friend +10 more
TL;DR: This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation, and may be valuable in increasing the number of donor livers and improving the function of transplantable organs.
Journal ArticleDOI
Liver Transplantation Using Donation After Cardiac Death Donors: Long-Term Follow-Up from a Single Center
M. E. de Vera,R Lopez-Solis,Igor Dvorchik,S Campos,W Morris,Anthony J. Demetris,Paulo Fontes,J. W. Marsh +7 more
TL;DR: There was a lack of survival benefit in DCD livers utilized in patients with model for end‐stage liver disease (MELD) ≤30 or those not on organ‐perfusion support, as graft survival was significantly lower compared to DBD patients, however, DCD and DBD subjects transplanted with MELD >30 or on organ-perfusions support had similar graft survival, suggesting a potentially greater benefit of DCDLivers in critically ill patients.
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