Journal ArticleDOI
Preliminary Single-Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial.
Mariusz Bral,Boris Gala-Lopez,David L. Bigam,Norman M. Kneteman,Andrew J. Malcolm,Scott Livingstone,Axel Andres,Juliet Emamaullee,Leslie James Russell,Constantin C. Coussios,Lori J. West,Peter J. Friend,A. M. J. Shapiro +12 more
TLDR
A preliminary single‐center North American experience using identical NMP technology demonstrates feasibility as well as potential technical risks of NMP in a North American setting and highlights a need for larger, randomized studies.About:
This article is published in American Journal of Transplantation.The article was published on 2017-04-01. It has received 170 citations till now. The article focuses on the topics: Liver function & Liver transplantation.read more
Citations
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Journal ArticleDOI
Evolving utilization of donation after circulatory death livers in liver transplantation: The day of DCD has come
TL;DR: In this article, the authors assessed how liver utilization and outcomes have changed over time, using OPTN data from adult, first-time, deceased donor, whole-organ LTs between January 1995 and December 2019.
Journal ArticleDOI
Does machine perfusion improve immediate and short‐term outcomes by enhancing graft function and recipient recovery after liver transplantation? A systematic review of the literature, meta‐analysis and expert panel recommendations
Alejandro Ramírez-Del Val,James V. Guarrera,Robert J. Porte,Markus Selzner,Michael Spiro,Dimitri A. Raptis,Peter J. Friend +6 more
TL;DR: The use of HMP decreases PRS and EAD, specifically for marginal grafts and shortens the length of hospital stay, and NRP decreases the likelihood of EAD and the risk of PNF when compared to both DBD and SRR-DCD grafts preserved in SCS.
Journal ArticleDOI
Donation after circulatory death liver transplantation : What are the limits for an acceptable DCD graft?
TL;DR: This review focused on the practice patterns in DCD liver graft utilization in the last decade, along with the possibilities for further expansion of DCD Liver graft utilization and new technologies, such as machine perfusion.
Journal ArticleDOI
Mitochondrial Consequences of Organ Preservation Techniques during Liver Transplantation
Tamara Horváth,Dávid Kurszán Jász,Bálint Baráth,Marietta Zita Poles,Mihály Boros,Petra Hartmann +5 more
TL;DR: In this paper, a systematic search was conducted using electronic databases (EMBASE, MEDLINE (via PubMed), the Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science) for controlled animal studies using preservation methods for liver transplantation.
Journal ArticleDOI
Normothermic Ex-vivo Liver Perfusion and the Clinical Implications for Liver Transplantation.
TL;DR: All relevant large and small animal research, as well as human liver studies on normothermic ex-vivo perfusion, are reviewed to identify areas of deficiency and opportunities for future research endeavors.
References
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Journal ArticleDOI
Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.
TL;DR: The new complication classification appears reliable and may represent a compelling tool for quality assessment in surgery in all parts of the world.
Journal ArticleDOI
Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
Kim M. Olthoff,Laura Kulik,Benjamin Samstein,Mary Kaminski,Michael Abecassis,Jean C. Emond,Abraham Shaked,Jason D. Christie +7 more
TL;DR: A simple definition of EAD using objective posttransplant criteria identified a 23% incidence, and was highly associated with graft loss and patient mortality, validating previously published criteria.
Journal ArticleDOI
Hypothermic Machine Preservation in Human Liver Transplantation: The First Clinical Series
James V. Guarrera,Scot D. Henry,Benjamin Samstein,R. Odeh‐Ramadan,M. Kinkhabwala,Michael J. Goldstein,Lloyd E. Ratner,John F. Renz,H. T. Lee,Robert S. Brown,Jean C. Emond +10 more
TL;DR: HMP of donor livers provided safe and reliable preservation in this pilot case‐controlled series and further multicenter HMP trials are now warranted.
Journal ArticleDOI
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
R. Ravikumar,Wayel Jassem,Hynek Mergental,Nigel Heaton,Darius F. Mirza,M. T. P. R. Perera,Alberto Quaglia,David Holroyd,Thomas Vogel,Constantin C. Coussios,Peter J. Friend +10 more
TL;DR: This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation, and may be valuable in increasing the number of donor livers and improving the function of transplantable organs.
Journal ArticleDOI
Liver Transplantation Using Donation After Cardiac Death Donors: Long-Term Follow-Up from a Single Center
M. E. de Vera,R Lopez-Solis,Igor Dvorchik,S Campos,W Morris,Anthony J. Demetris,Paulo Fontes,J. W. Marsh +7 more
TL;DR: There was a lack of survival benefit in DCD livers utilized in patients with model for end‐stage liver disease (MELD) ≤30 or those not on organ‐perfusion support, as graft survival was significantly lower compared to DBD patients, however, DCD and DBD subjects transplanted with MELD >30 or on organ-perfusions support had similar graft survival, suggesting a potentially greater benefit of DCDLivers in critically ill patients.
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A randomized trial of normothermic preservation in liver transplantation
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