Journal ArticleDOI
Preliminary Single-Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial.
Mariusz Bral,Boris Gala-Lopez,David L. Bigam,Norman M. Kneteman,Andrew J. Malcolm,Scott Livingstone,Axel Andres,Juliet Emamaullee,Leslie James Russell,Constantin C. Coussios,Lori J. West,Peter J. Friend,A. M. J. Shapiro +12 more
TLDR
A preliminary single‐center North American experience using identical NMP technology demonstrates feasibility as well as potential technical risks of NMP in a North American setting and highlights a need for larger, randomized studies.About:
This article is published in American Journal of Transplantation.The article was published on 2017-04-01. It has received 170 citations till now. The article focuses on the topics: Liver function & Liver transplantation.read more
Citations
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Journal ArticleDOI
Normothermic Machine Perfusion versus Cold Storage of Liver in Pig Model: A Meta-Analysis
TL;DR: A meta-analysis of the literature showed that NMP provides superior graft preservation compared with CS in the pig model and had a similar 5–7-days survival rate after liver transplantation compared with the CS group.
Journal ArticleDOI
Role of perfusion machines in the setting of clinical liver transplantation: A qualitative systematic review
TL;DR: Donor characteristics, evaluation of graft quality, and endpoints were not homogeneous among the studies, and overall, post‐LT results were excellent, with 1.2 and 4.0% of patients experienced primary non‐function and ischemic‐type biliary lesions, respectively.
Journal ArticleDOI
Anticoagulant Management and Synthesis of Hemostatic Proteins during Machine Preservation of Livers for Transplantation.
TL;DR: This review addresses the modalities of machine perfusion currently being applied, and particularly focuses on the hemostatic management employed during machine perfusions, and discusses the possibilities and limitations of utilizing the synthesis of liver-derived coagulation factors as potential viability markers.
Journal ArticleDOI
Cold flush after dynamic liver preservation protects against ischemic changes upon reperfusion – an experimental study
Charlotte von Horn,Patrick Hannaert,Thierry Hauet,Henri G. D. Leuvenink,Andreas Paul,Thomas Minor +5 more
TL;DR: Post‐machine preservationCold reflush after disconnection from the machine resulted in a significant increase in bile production upon blood reperfusion, along with a significant reduction in transaminases release alanine aminotransferase and of the intramitochondrial enzyme glutamate dehydrogenase.
Journal ArticleDOI
Concise review of machine perfusion in liver transplantation.
Chirag S. Desai,David A. Gerber +1 more
TL;DR: Clinical trials and recent advances that will likely have the earliest entrance into the clinical arena for deceased donor livers are focused on.
References
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Journal ArticleDOI
Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.
TL;DR: The new complication classification appears reliable and may represent a compelling tool for quality assessment in surgery in all parts of the world.
Journal ArticleDOI
Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
Kim M. Olthoff,Laura Kulik,Benjamin Samstein,Mary Kaminski,Michael Abecassis,Jean C. Emond,Abraham Shaked,Jason D. Christie +7 more
TL;DR: A simple definition of EAD using objective posttransplant criteria identified a 23% incidence, and was highly associated with graft loss and patient mortality, validating previously published criteria.
Journal ArticleDOI
Hypothermic Machine Preservation in Human Liver Transplantation: The First Clinical Series
James V. Guarrera,Scot D. Henry,Benjamin Samstein,R. Odeh‐Ramadan,M. Kinkhabwala,Michael J. Goldstein,Lloyd E. Ratner,John F. Renz,H. T. Lee,Robert S. Brown,Jean C. Emond +10 more
TL;DR: HMP of donor livers provided safe and reliable preservation in this pilot case‐controlled series and further multicenter HMP trials are now warranted.
Journal ArticleDOI
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
R. Ravikumar,Wayel Jassem,Hynek Mergental,Nigel Heaton,Darius F. Mirza,M. T. P. R. Perera,Alberto Quaglia,David Holroyd,Thomas Vogel,Constantin C. Coussios,Peter J. Friend +10 more
TL;DR: This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation, and may be valuable in increasing the number of donor livers and improving the function of transplantable organs.
Journal ArticleDOI
Liver Transplantation Using Donation After Cardiac Death Donors: Long-Term Follow-Up from a Single Center
M. E. de Vera,R Lopez-Solis,Igor Dvorchik,S Campos,W Morris,Anthony J. Demetris,Paulo Fontes,J. W. Marsh +7 more
TL;DR: There was a lack of survival benefit in DCD livers utilized in patients with model for end‐stage liver disease (MELD) ≤30 or those not on organ‐perfusion support, as graft survival was significantly lower compared to DBD patients, however, DCD and DBD subjects transplanted with MELD >30 or on organ-perfusions support had similar graft survival, suggesting a potentially greater benefit of DCDLivers in critically ill patients.
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