Journal ArticleDOI
Preliminary Single-Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial.
Mariusz Bral,Boris Gala-Lopez,David L. Bigam,Norman M. Kneteman,Andrew J. Malcolm,Scott Livingstone,Axel Andres,Juliet Emamaullee,Leslie James Russell,Constantin C. Coussios,Lori J. West,Peter J. Friend,A. M. J. Shapiro +12 more
TLDR
A preliminary single‐center North American experience using identical NMP technology demonstrates feasibility as well as potential technical risks of NMP in a North American setting and highlights a need for larger, randomized studies.About:
This article is published in American Journal of Transplantation.The article was published on 2017-04-01. It has received 170 citations till now. The article focuses on the topics: Liver function & Liver transplantation.read more
Citations
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Journal ArticleDOI
Comprehensive Approach to Assessment of Liver Viability During Normothermic Machine Perfusion
TL;DR: In this paper , a review summarizes the criteria, indicators, and methods used to evaluate liver viability during normothermic machine perfusion (NMP) during liver transplantation, including shape, appearance, and hemodynamics of the liver.
Journal ArticleDOI
The role of normothermic machine perfusion (NMP) in the preservation of ex-vivo liver before transplantation: A review
TL;DR: In contrast to traditional static cold preservation of donor livers, normothermic machine perfusion (NMP) may reduce preservation injury, improve graft viability, and potentially ex vivo assessment of graft viability before transplant as discussed by the authors .
Journal ArticleDOI
Normothermic Ex Vivo Machine Perfusion for Liver Transplantation: A Systematic Review of Progress in Humans
Charles Risbey,Carlo Pulitano +1 more
TL;DR: In this article, the authors investigated the clinical progress of ex vivo normothermic machine perfusion (NMP) for liver transplantation in humans and found good evidence to suggest that NMP is safe and that it likely affords clinical advantages to static cold storage (SCS).
Journal ArticleDOI
Moderne Konzepte zur dynamischen Konservierung von Leber und Nieren im Rahmen einer Transplantation
Charlotte von Horn,Thomas Minor +1 more
TL;DR: Hypothermic, oxygenated machine perfusion is a classical method of dynamic organ preservation, which enables the provision of oxygen and nutrients to the tissue and provides a metabolic recovery of the graft prior to implantation and a strategy to circumvent this phenomenon is controlled oxygenated rewarming.
Journal ArticleDOI
Innate Immune Cells during Machine Perfusion of Liver Grafts—The Janus Face of Hepatic Macrophages
TL;DR: In this paper , the authors provide an overview of the current data regarding the immunomodulatory role of machine perfusion and emphasize the importance of macrophages for hepatic ischemia-reperfusion injury.
References
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Journal ArticleDOI
Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.
TL;DR: The new complication classification appears reliable and may represent a compelling tool for quality assessment in surgery in all parts of the world.
Journal ArticleDOI
Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
Kim M. Olthoff,Laura Kulik,Benjamin Samstein,Mary Kaminski,Michael Abecassis,Jean C. Emond,Abraham Shaked,Jason D. Christie +7 more
TL;DR: A simple definition of EAD using objective posttransplant criteria identified a 23% incidence, and was highly associated with graft loss and patient mortality, validating previously published criteria.
Journal ArticleDOI
Hypothermic Machine Preservation in Human Liver Transplantation: The First Clinical Series
James V. Guarrera,Scot D. Henry,Benjamin Samstein,R. Odeh‐Ramadan,M. Kinkhabwala,Michael J. Goldstein,Lloyd E. Ratner,John F. Renz,H. T. Lee,Robert S. Brown,Jean C. Emond +10 more
TL;DR: HMP of donor livers provided safe and reliable preservation in this pilot case‐controlled series and further multicenter HMP trials are now warranted.
Journal ArticleDOI
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
R. Ravikumar,Wayel Jassem,Hynek Mergental,Nigel Heaton,Darius F. Mirza,M. T. P. R. Perera,Alberto Quaglia,David Holroyd,Thomas Vogel,Constantin C. Coussios,Peter J. Friend +10 more
TL;DR: This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation, and may be valuable in increasing the number of donor livers and improving the function of transplantable organs.
Journal ArticleDOI
Liver Transplantation Using Donation After Cardiac Death Donors: Long-Term Follow-Up from a Single Center
M. E. de Vera,R Lopez-Solis,Igor Dvorchik,S Campos,W Morris,Anthony J. Demetris,Paulo Fontes,J. W. Marsh +7 more
TL;DR: There was a lack of survival benefit in DCD livers utilized in patients with model for end‐stage liver disease (MELD) ≤30 or those not on organ‐perfusion support, as graft survival was significantly lower compared to DBD patients, however, DCD and DBD subjects transplanted with MELD >30 or on organ-perfusions support had similar graft survival, suggesting a potentially greater benefit of DCDLivers in critically ill patients.
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