Journal ArticleDOI
Preliminary Single-Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial.
Mariusz Bral,Boris Gala-Lopez,David L. Bigam,Norman M. Kneteman,Andrew J. Malcolm,Scott Livingstone,Axel Andres,Juliet Emamaullee,Leslie James Russell,Constantin C. Coussios,Lori J. West,Peter J. Friend,A. M. J. Shapiro +12 more
TLDR
A preliminary single‐center North American experience using identical NMP technology demonstrates feasibility as well as potential technical risks of NMP in a North American setting and highlights a need for larger, randomized studies.About:
This article is published in American Journal of Transplantation.The article was published on 2017-04-01. It has received 170 citations till now. The article focuses on the topics: Liver function & Liver transplantation.read more
Citations
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Journal ArticleDOI
Transplantation of declined livers after normothermic perfusion.
Cristiano Quintini,Luca Del Prete,Andrea Simioni,L Del Angel,Teresa Diago Uso,Giuseppe D'Amico,Koji Hashimoto,Federico Aucejo,Masato Fujiki,Bijan Eghtesad,Kazunari Sasaki,Choon Hyuck David Kwon,Jacek B. Cywinski,A.C. Bennett,M. Bilancini,Charles C. Miller,Qiang Liu +16 more
TL;DR: In this paper , the authors report that 71.5% of discarded liver allografts were successfully transplanted after ex vivo normothermic machine perfusion and assessment using an institutionally built device.
Journal ArticleDOI
Strategies to Restore Adenosine Triphosphate (ATP) Level After More than 20 Hours of Cold Ischemia Time in Human Marginal Kidney Grafts.
Matteo Ravaioli,Maurizio Baldassare,Francesco Vasuri,Gianandrea Pasquinelli,Maristella Laggetta,Sabrina Valente,Vanessa De Pace,Flavia Neri,Antonio Siniscalchi,Chiara Zanfi,Valentina Rosa Bertuzzo,Paolo Caraceni,Davide Treré,Pasquale Longobardi,Antonio Daniele Pinna +14 more
TL;DR: Hyperbaric or normobaric oxygenation with perfusion improves organ metabolic preservation compared to other methods and may prevent the onset of delayed graft function, but clinical trials are needed to confirm this.
Journal ArticleDOI
Heme oxygenase-1-modified bone marrow mesenchymal stem cells combined with normothermic machine perfusion to protect donation after circulatory death liver grafts
Huan Cao,Liu Yang,Liu Yang,Bin Hou,Dong Sun,Ling Lin,Hong-Li Song,Zhongyang Shen,Zhongyang Shen +8 more
TL;DR: Hme oxygenase 1-modified bone marrow-derived mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) exerted protective effects on DCD donor liver and significantly improved recipient prognosis.
Journal ArticleDOI
Preliminary experience of sequential use of normothermic and hypothermic oxygenated perfusion for donation after circulatory death kidney with warm ischemia time over the conventional criteria - a retrospective and observational study.
Matteo Ravaioli,Vanessa De Pace,Giorgia Comai,Irene Capelli,Olga Baraldi,Antonietta D'Errico,Valentina Rosa Bertuzzo,Massimo Del Gaudio,Chiara Zanfi,Giovanni Liviano D'Arcangelo,Vania Cuna,Antonio Siniscalchi,Gabriela Sangiorgi,Gaetano La Manna +13 more
TL;DR: Preliminary experience of sequential use of normothermic regional perfusion and hypothermic oxygenated perfusion for DCD may overcome fWIT limits safely, and lactate during HOPE predicts DGF, is reported.
Journal ArticleDOI
Bioengineering approaches to organ preservation ex vivo.
TL;DR: An overview of the current status of ex vivo machine perfusion in the pre-clinical and clinical setting is provided and a perspective on the future direction of the field is shared.
References
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Journal ArticleDOI
Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.
TL;DR: The new complication classification appears reliable and may represent a compelling tool for quality assessment in surgery in all parts of the world.
Journal ArticleDOI
Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
Kim M. Olthoff,Laura Kulik,Benjamin Samstein,Mary Kaminski,Michael Abecassis,Jean C. Emond,Abraham Shaked,Jason D. Christie +7 more
TL;DR: A simple definition of EAD using objective posttransplant criteria identified a 23% incidence, and was highly associated with graft loss and patient mortality, validating previously published criteria.
Journal ArticleDOI
Hypothermic Machine Preservation in Human Liver Transplantation: The First Clinical Series
James V. Guarrera,Scot D. Henry,Benjamin Samstein,R. Odeh‐Ramadan,M. Kinkhabwala,Michael J. Goldstein,Lloyd E. Ratner,John F. Renz,H. T. Lee,Robert S. Brown,Jean C. Emond +10 more
TL;DR: HMP of donor livers provided safe and reliable preservation in this pilot case‐controlled series and further multicenter HMP trials are now warranted.
Journal ArticleDOI
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
R. Ravikumar,Wayel Jassem,Hynek Mergental,Nigel Heaton,Darius F. Mirza,M. T. P. R. Perera,Alberto Quaglia,David Holroyd,Thomas Vogel,Constantin C. Coussios,Peter J. Friend +10 more
TL;DR: This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation, and may be valuable in increasing the number of donor livers and improving the function of transplantable organs.
Journal ArticleDOI
Liver Transplantation Using Donation After Cardiac Death Donors: Long-Term Follow-Up from a Single Center
M. E. de Vera,R Lopez-Solis,Igor Dvorchik,S Campos,W Morris,Anthony J. Demetris,Paulo Fontes,J. W. Marsh +7 more
TL;DR: There was a lack of survival benefit in DCD livers utilized in patients with model for end‐stage liver disease (MELD) ≤30 or those not on organ‐perfusion support, as graft survival was significantly lower compared to DBD patients, however, DCD and DBD subjects transplanted with MELD >30 or on organ-perfusions support had similar graft survival, suggesting a potentially greater benefit of DCDLivers in critically ill patients.
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