Journal ArticleDOI
Preliminary Single-Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial.
Mariusz Bral,Boris Gala-Lopez,David L. Bigam,Norman M. Kneteman,Andrew J. Malcolm,Scott Livingstone,Axel Andres,Juliet Emamaullee,Leslie James Russell,Constantin C. Coussios,Lori J. West,Peter J. Friend,A. M. J. Shapiro +12 more
TLDR
A preliminary single‐center North American experience using identical NMP technology demonstrates feasibility as well as potential technical risks of NMP in a North American setting and highlights a need for larger, randomized studies.About:
This article is published in American Journal of Transplantation.The article was published on 2017-04-01. It has received 170 citations till now. The article focuses on the topics: Liver function & Liver transplantation.read more
Citations
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Journal ArticleDOI
Observations on the ex situ perfusion of livers for transplantation.
Christopher J.E. Watson,Vasilis Kosmoliaptsis,Caitlin Pley,Lucy V. Randle,Corinna Fear,Keziah Crick,Alexander Gimson,Michael Allison,Sara Upponi,Rebecca Brais,Ina Jochmans,Andrew J. Butler +11 more
TL;DR: Evaluation of bile pH may offer a valuable insight into bile duct integrity and risk of posttransplant ischemic cholangiopathy, as well as a combination of transaminase release, glucose metabolism, lactate clearance, and maintenance of acid‐base balance.
Journal ArticleDOI
Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial
Rianne van Rijn,Ivo J. Schurink,Yvonne de Vries,Aad P. van den Berg,Miriam Cortes Cerisuelo,Sarwa Darwish Murad,Joris I. Erdmann,Nicholas Gilbo,Robbert J. de Haas,Nigel Heaton,Bart van Hoek,Volkert A.L. Huurman,Ina Jochmans,Otto B. van Leeuwen,Vincent E de Meijer,D. Monbaliu,W.G. Polak,Jules J.G. Slangen,Roberto I. Troisi,Aude Vanlander,Jeroen de Jonge,Robert J. Porte +21 more
TL;DR: In this article, the authors showed that liver transplantation after circulatory death is associated with an increased risk of nonanastomotic biliary strictures and hypothermic oxygenated machine (HOMEM) was used to treat the strictures.
Journal ArticleDOI
Outcomes of DCD liver transplantation using organs treated by hypothermic oxygenated perfusion before implantation
Andrea Schlegel,Andrea Schlegel,Xavier Muller,Marit Kalisvaart,Beat Muellhaupt,M. Thamara P. R. Perera,John Isaac,Pierre-Alain Clavien,Paolo Muiesan,Philipp Dutkowski +9 more
TL;DR: 5-year graft survival in donation after cardiac death livers treated by conventional cold storage, or by 1-2 h of hypothermic oxygenated perfusion (HOPE) after cold storage suggests that a simple end-ischaemic perfusion approach is very effective and may open the field for safe utilisation of extended DCD liver grafts.
Journal ArticleDOI
Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation.
Amelia J. Hessheimer,Elisabeth Coll,Ferran Torres,Patricia Ruiz,Mikel Gastaca,José Ignacio Rivas,Manuel Gómez,B. Sanchez,Julio Santoyo,Pablo Ramírez,Pascual Parrilla,Luis Miguel Marín,Miguel Ángel Gómez-Bravo,Juan Carlos García-Valdecasas,Javier López-Monclús,Andrea Boscá,Rafael López-Andújar,Jiliam Fundora-Suárez,Jesús Villar,Álvaro García-Sesma,Carlos Jiménez,G. Rodriguez-Laiz,Laura Lladó,Juan Carlos Rodríguez,Manuel Barrera,Ramón Charco,Jose Ángel López-Baena,Javier Briceño,Fernando Pardo,Gerardo Blanco,David Pacheco,Beatriz Domínguez-Gil,Víctor Sánchez Turrión,Constantino Fondevila +33 more
TL;DR: The study results suggest that the use of postmortem normothermic regional perfusion helps reduce rates of post-transplant biliary complications and graft loss and allows for the successful transplantation of livers from older cDCD donors of advanced age.
Journal ArticleDOI
Novel Real-time Prediction of Liver Graft Function During Hypothermic Oxygenated Machine Perfusion Before Liver Transplantation
Xavier Muller,Andrea Schlegel,Philipp Kron,Dilmurodjon Eshmuminov,Michael Würdinger,David Meierhofer,Pierre-Alain Clavien,Philipp Dutkowski +7 more
TL;DR: Assessment of flavin, a marker of mitochondrial complex I injury, in the perfusate provides a fast prediction of liver graft function and loss during ex situ MP before implantation, which may have high clinical relevance, as liver grafts from extended DBD or DCD donors carry considerable risks for recipients.
References
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Journal ArticleDOI
Preimplant Normothermic Liver Perfusion of a Suboptimal Liver Donated After Circulatory Death.
Christopher J.E. Watson,Vasilis Kosmoliaptsis,Lucy V. Randle,Neil Russell,W. J. H. Griffiths,Scott P Davies,Hynek Mergental,Andrew J. Butler +7 more
TL;DR: Preimplant ex situ normothermic perfusion of the liver appears to be a promising way to evaluate a marginal liver before transplantation and may modify the response to ischemia.
Journal ArticleDOI
First human liver transplantation using a marginal allograft resuscitated by normothermic machine perfusion
Thamara Perera,Hynek Mergental,Barney Stephenson,Garrett R. Roll,Hentie Cilliers,Richard Liang,Roberta Angelico,Stefan G. Hubscher,Desley Neil,Gary M. Reynolds,John Isaac,David A. Adams,S. Afford,Darius F. Mirza,Paolo Muiesan +14 more
TL;DR: The first report of transplantation of a graft salvaged by postischemia NMLP is presented, with a follow-up period of 15 months, derived from this technology’s unique ability to assess viability during storage.
Journal ArticleDOI
Sirolimus-Based Immunosuppression Is Associated with Increased Survival After Liver Transplantation for Hepatocellular Carcinoma
Journal ArticleDOI
Normothermic liver preservation: a new paradigm?
TL;DR: Normothermic perfusion maintains the organ in a physiological state, avoiding the depletion of cellular energy and the accumulation of waste products, which occurs with static cold storage and enables viability assessment prior to transplantation thereby reducing the risk of transplanting inherently marginal organs.
Journal ArticleDOI
Biomarkers to assess graft quality during conventional and machine preservation in liver transplantation
Cornelia J. Verhoeven,Waqar R. R. Farid,Jeroen de Jonge,Herold J. Metselaar,Geert Kazemier,Luc J. W. van der Laan +5 more
TL;DR: The biomarkers presented in this review provide a useful handle to monitor recovery of ECD grafts during clinical MP in the near future and could potentially be applied as predictive markers during MP.
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A randomized trial of normothermic preservation in liver transplantation
D Nasralla,Constantin C. Coussios,Hynek Mergental,M. Zeeshan Akhtar,Andrew J. Butler,Carlo D L Ceresa,Virginia Chiocchia,Susan J Dutton,Juan Carlos García-Valdecasas,Nigel Heaton,Charles Imber,Wayel Jassem,Ina Jochmans,John Karani,Simon R. Knight,Simon R. Knight,Peri Kocabayoglu,Massimo Malagó,Darius F. Mirza,Peter J. Morris,Peter J. Morris,Arvind Pallan,Andreas Paul,Mihai Pavel,M. Thamara P. R. Perera,Jacques Pirenne,R. Ravikumar,Leslie James Russell,Sara Upponi,Christopher J.E. Watson,Annemarie Weissenbacher,Rutger J. Ploeg,Peter J. Friend +32 more