Journal ArticleDOI
Prospective associations of low muscle mass and function with 10-year falls risk, incident fracture and mortality in community-dwelling older adults
Saliu Balogun,Tania Winzenberg,Karen Wills,David Scott,David Scott,Graeme Jones,Dawn Aitken,Michele L. Callisaya,Michele L. Callisaya +8 more
TLDR
Low handgrip strength, a simple and inexpensive test could be considered in clinical settings for identifying future falls and fractures, and ALM/ body mass index could be most suitable in estimating 10-year mortality risk, but requires specialised equipment.Abstract:
To compare the performance of low muscle mass and function with falls risk, incident fracture and mortality over 10 years. 1041 participants (50% women; mean age 63±7.5 years) were prospectively followed for 10 years. Falls risk was measured using the Physiological Profile Assessment, fractures were self-reported and mortality was ascertained from the death registry. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry. Four anthropometric: (ALM/height2, ALM/body mass index, ALM/weight×100, a residuals method of ALM on height and total body fat) and four performance-based measures: (handgrip strength, lower-limb muscle strength, upper and lower-limb muscle quality) were examined. Participants in the lowest 20% of the sex-specific distribution for each anthropometric and performance-based measure were classified has having low muscle mass or function. Regression analyses were used to estimate associations between each anthropometric and performance-based measure at baseline and 10-year falls risk, incident fractures and mortality. Mean falls risk z-score at 10 years was 0.64 (SD 1.12), incident fractures and mortality over 10 years were 16% and 14% respectively. All baseline performancebased measures were significantly associated with higher falls risk score at 10 years. Low handgrip (RR 1.55, 95% CI: 1.09, 2.20) and ALM/body mass index (RR 1.54, 95% CI: 1.14, 2.08) were the only significant predictors of fracture and mortality respectively. Low handgrip strength, a simple and inexpensive test could be considered in clinical settings for identifying future falls and fractures. ALM/ body mass index could be most suitable in estimating 10-year mortality risk, but requires specialised equipment.read more
Citations
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Journal ArticleDOI
Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis
Suey S.Y. Yeung,Suey S.Y. Yeung,Esmee M. Reijnierse,Vivien K Pham,M.C. Trappenburg,Wen Kwang Lim,Carel G. M. Meskers,Andrea B. Maier,Andrea B. Maier +8 more
TL;DR: The positive association between sarcopenia with falls and fractures in older adults strengthens the need to invest in sarc Openia prevention and interventions to evaluate its effect on falls and fracture.
Journal ArticleDOI
Short-Physical Performance Battery (SPPB) score is associated with falls in older outpatients
Fulvio Lauretani,Andrea Ticinesi,Luciano Gionti,Beatrice Prati,Antonio Nouvenne,Claudio Tana,Tiziana Meschi,Marcello Maggio +7 more
TL;DR: SPPB total score was independently associated with reported falls in older outpatients, resulting non-inferior to POMA scale, and the use of SPPB for fall risk assessment should be implemented.
Journal ArticleDOI
Protective role of Parkin in skeletal muscle contractile and mitochondrial function
Gilles Gouspillou,Richard Godin,Jérôme Piquereau,Jérôme Piquereau,Martin Picard,Martin Picard,Mahroo Mofarrahi,Jasmin Mathew,Fennigje M. Purves-Smith,Nicolas Sgarioto,Nicolas Sgarioto,Russell T. Hepple,Yan Burelle,Sabah N. A. Hussain +13 more
TL;DR: Parkin has been implicated in the regulation of mitophagy, a quality control process in which defective mitochondria are degraded as mentioned in this paper, and Parkin ablation causes a decrease in muscle specific force, a severe decrease in mitochondrial respiration, mitochondrial uncoupling and an increased susceptibility to opening of the permeability transition pore.
Journal ArticleDOI
Relationship between muscle strength and fall episodes among the elderly: the Yilan study, Taiwan
Nan-Ping Yang,Nan-Ping Yang,Nai Wei Hsu,Ching-Heng Lin,Hsi-Chung Chen,Hsi-Chung Chen,Hsuan Ming Tsao,Su Shun Lo,Pesus Chou +8 more
TL;DR: Less weekly exercise duration and weaker muscle strength were found to be independent risk factors of fall episode(s) in an elderly Taiwanese population, especially in the female sub-population.
Journal ArticleDOI
The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study
TL;DR: It is concluded that HI-RT is a feasible, highly efficient and safe training modality for combating sarcopenia, also in the elderly.
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TL;DR: Based on the analyses presented in this series, the final recommended cutpoints for weakness are grip strength <26kg for men and <16kg for women, and for low lean mass, appendicular lean mass adjusted for body mass index <0.789 forMen and women.
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