Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
Jan C. Buckner,Edward G. Shaw,Stephanie L. Pugh,Arnab Chakravarti,Mark R. Gilbert,Geoffrey R. Barger,Stephen W. Coons,Peter Ricci,Dennis E. Bullard,Paul D. Brown,Keith J. Stelzer,David Brachman,John H. Suh,Christopher J. Schultz,Jean Paul Bahary,Barbara Fisher,Barbara Fisher,Harold Kim,Albert Murtha,Erica Hlavin Bell,Minhee Won,Minesh P. Mehta,Walter J. Curran +22 more
TLDR
In a cohort of patients with grade 2 glioma who were younger than 40 years of age and had undergone subtotal tumor resection or who were 40 yearsof age or older, progression-free survival and overall survival were longer among those who received combination chemotherapy in addition to radiation therapy than amongThose who received radiation therapy alone.Abstract:
BackgroundGrade 2 gliomas occur most commonly in young adults and cause progressive neurologic deterioration and premature death. Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), and vincristine after radiation therapy at the time of initial diagnosis resulted in longer progression-free survival, but not overall survival, than radiation therapy alone. We now report the long-term results. MethodsWe included patients with grade 2 astrocytoma, oligoastrocytoma, or oligodendroglioma who were younger than 40 years of age and had undergone subtotal resection or biopsy or who were 40 years of age or older and had undergone biopsy or resection of any of the tumor. Patients were stratified according to age, histologic findings, Karnofsky performance-status score, and presence or absence of contrast enhancement on preoperative images. Patients were randomly assigned to radiation therapy alone or to radiation therapy followed by six cycles of combination chemotherapy...read more
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Identification of a three-long non-coding RNA signature for predicting survival of temozolomide-treated isocitrate dehydrogenase mutant low-grade gliomas.
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Multi-institutional study of treatment patterns in Korean patients with WHO grade II gliomas: KNOG 15-02 and KROG 16-04 intergroup study
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Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma
Dieter Henrik Heiland,Robin Ohle,Debora Cipriani,Pamela Franco,Daniel Delev,Simon P. Behriger,Elias Kellner,Gergana Petrova,Nicolas Neidert,Irina Mader,Mateo Fariña Nuñez,Horst Urbach,Roman Sankowski,Jürgen Beck,Oliver Schnell +14 more
TL;DR: It was showed that, surgical resection is beneficial for overall survival regardless the WHO grad or timepoint of surgery, and an extent of resection above 50% is required to improve overall survival, and the data aids to improve the interpretation of MRI images in clinical practice.
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Basic premises: searching for new targets and strategies in diffuse gliomas
TL;DR: In this article , a literature review for articles on the topic in PubMed, Google Scholar, and Web of Science until January 2022 is presented, focusing on its molecular determinants with major prognostic and therapeutic significance.
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Origin and development of oligodendroglioma
TL;DR: This chapter will review oligodendroglioma initiation and progression in the context of a cell of origin in addition to how asymmetric division and the stem cell niche are important for stem cell maintenance and regulation.
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