Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
Jan C. Buckner,Edward G. Shaw,Stephanie L. Pugh,Arnab Chakravarti,Mark R. Gilbert,Geoffrey R. Barger,Stephen W. Coons,Peter Ricci,Dennis E. Bullard,Paul D. Brown,Keith J. Stelzer,David Brachman,John H. Suh,Christopher J. Schultz,Jean Paul Bahary,Barbara Fisher,Barbara Fisher,Harold Kim,Albert Murtha,Erica Hlavin Bell,Minhee Won,Minesh P. Mehta,Walter J. Curran +22 more
TLDR
In a cohort of patients with grade 2 glioma who were younger than 40 years of age and had undergone subtotal tumor resection or who were 40 yearsof age or older, progression-free survival and overall survival were longer among those who received combination chemotherapy in addition to radiation therapy than amongThose who received radiation therapy alone.Abstract:
BackgroundGrade 2 gliomas occur most commonly in young adults and cause progressive neurologic deterioration and premature death. Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), and vincristine after radiation therapy at the time of initial diagnosis resulted in longer progression-free survival, but not overall survival, than radiation therapy alone. We now report the long-term results. MethodsWe included patients with grade 2 astrocytoma, oligoastrocytoma, or oligodendroglioma who were younger than 40 years of age and had undergone subtotal resection or biopsy or who were 40 years of age or older and had undergone biopsy or resection of any of the tumor. Patients were stratified according to age, histologic findings, Karnofsky performance-status score, and presence or absence of contrast enhancement on preoperative images. Patients were randomly assigned to radiation therapy alone or to radiation therapy followed by six cycles of combination chemotherapy...read more
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The medical necessity of advanced molecular testing in the diagnosis and treatment of brain tumor patients.
Craig Horbinski,Keith L. Ligon,Priscilla K. Brastianos,Jason T. Huse,Monica Venere,Susan M. Chang,Jan C. Buckner,Timothy F. Cloughesy,Robert B. Jenkins,Caterina Giannini,L. Burt Nabors,Patrick Y. Wen,Kenneth Aldape,Rimas V. Lukas,Evanthia Galanis,Charles G. Eberhart,Charles G. Eberhart,Daniel J. Brat,Jann N. Sarkaria +18 more
TL;DR: This review examines barriers to adoption of molecular testing in brain tumors, and describes the current molecular tools recommended for the clinical evaluation of brain tumors to improve understanding and justification for their coverage in the routine workup of adult and pediatric brain tumor cases.
Journal ArticleDOI
Genotype-targeted local therapy of glioma.
Ganesh M. Shankar,Ameya R. Kirtane,Julie J. Miller,Hormoz Mazdiyasni,Jaimie Rogner,Tai Tammy,Erik A. Williams,Fumi Higuchi,Tareq A. Juratli,Kensuke Tateishi,Koerner Mva,Shilpa S. Tummala,Avner Fink,Tristan Penson,Stephen P. Schmidt,Gregory R. Wojtkiewicz,Aymen Baig,Joshua M. Francis,Mikael L. Rinne,Mikael L. Rinne,Julie M. Batten,Tracy T. Batchelor,Priscilla K. Brastianos,William T. Curry,Barker Fg nd,Justin T. Jordan,Anthony J. Iafrate,Andrew S. Chi,Jochen K. Lennerz,Matthew Meyerson,Matthew Meyerson,Robert Langer,Hiroaki Wakimoto,Giovanni Traverso,Giovanni Traverso,Daniel P. Cahill +35 more
TL;DR: A precision intraoperative treatment that couples a rapid multiplexed genotyping tool with a sustained release microparticle drug delivery system containing an IDH-directed nicotinamide phosphoribosyltransferase (NAMPT) inhibitor (GMX-1778) and validated the genetic diagnostic tool on clinically annotated tumor specimens.
Journal ArticleDOI
IDH wild-type WHO grade II diffuse low-grade gliomas. A heterogeneous family with different outcomes. Systematic review and meta-analysis.
Davide Tiziano Di Carlo,Hugues Duffau,Federico Cagnazzo,Nicola Benedetto,Riccardo Morganti,Paolo Perrini +5 more
TL;DR: A systematic review and meta-analysis of literature examining epidemiology, clinical characteristics, management, and the outcome of IDH-wt grade II DLGGs revealed that Maximal surgical resection improves the overall survival in theDLGGs population, beyond molecular status.
Journal ArticleDOI
Intra-rater variability in low-grade glioma segmentation
Hans Kristian Bø,Ole Solheim,Asgeir Store Jakola,Kjell-Arne Kvistad,Ingerid Reinertsen,Erik Magnus Berntsen +5 more
TL;DR: It is found that the intra-rater variability can be considerable in serial LGG-segmentation, but the variability seems to decrease with experience and higher grade of border conspicuity, which highlights that some criteria defining tumor borders and progression in 3D volumetric segmentation is needed, if moving from 2D to 3D assessment of size and growth of LGGs.
Journal ArticleDOI
Clinical Management of Diffuse Low-Grade Gliomas.
Giuseppe Lombardi,Valeria Barresi,Antonella Castellano,Emeline Tabouret,Francesco Pasqualetti,Alessandro Salvalaggio,Giulia Cerretti,Mario Caccese,Marta Padovan,Vittorina Zagonel,Tamara Ius +10 more
TL;DR: Optimal post-operative management of LGG is still controversial, though radiation therapy and chemotherapy remain the optimal treatments after surgical resection in selected patients, and new opportunities for personalized targeted therapy and supportive care are reported.
References
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