Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
Jan C. Buckner,Edward G. Shaw,Stephanie L. Pugh,Arnab Chakravarti,Mark R. Gilbert,Geoffrey R. Barger,Stephen W. Coons,Peter Ricci,Dennis E. Bullard,Paul D. Brown,Keith J. Stelzer,David Brachman,John H. Suh,Christopher J. Schultz,Jean Paul Bahary,Barbara Fisher,Barbara Fisher,Harold Kim,Albert Murtha,Erica Hlavin Bell,Minhee Won,Minesh P. Mehta,Walter J. Curran +22 more
TLDR
In a cohort of patients with grade 2 glioma who were younger than 40 years of age and had undergone subtotal tumor resection or who were 40 yearsof age or older, progression-free survival and overall survival were longer among those who received combination chemotherapy in addition to radiation therapy than amongThose who received radiation therapy alone.Abstract:
BackgroundGrade 2 gliomas occur most commonly in young adults and cause progressive neurologic deterioration and premature death. Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), and vincristine after radiation therapy at the time of initial diagnosis resulted in longer progression-free survival, but not overall survival, than radiation therapy alone. We now report the long-term results. MethodsWe included patients with grade 2 astrocytoma, oligoastrocytoma, or oligodendroglioma who were younger than 40 years of age and had undergone subtotal resection or biopsy or who were 40 years of age or older and had undergone biopsy or resection of any of the tumor. Patients were stratified according to age, histologic findings, Karnofsky performance-status score, and presence or absence of contrast enhancement on preoperative images. Patients were randomly assigned to radiation therapy alone or to radiation therapy followed by six cycles of combination chemotherapy...read more
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Book ChapterDOI
Radiation Therapy in the Treatment of Low Grade Gliomas
Hunter Boggs,Minesh Mehta +1 more
TL;DR: This chapter will address controversies of dose, timing, techniques, recent advances in the field and the benefit of systemic therapy.
Journal ArticleDOI
A Multigene Signature Associated with Progression-Free Survival after Treatment for IDH Mutant and 1p/19q Codeleted Oligodendrogliomas
Julia Gilhodes,Bastien Cabarrou,Guillaume Peyraga,Caroline Dehais,Dominique Figarella-Branger,François Ducray,Claude-Alain Maurage,Delphine Loussouarn,Emmanuelle Uro-Coste,Elizabeth Cohen-Jonathan Moyal +9 more
TL;DR: In this article , the authors extracted total RNA from frozen tumor samples and investigated enriched pathways using KEGG and Reactome databases to identify gene expressions associated with response to treatment from a national cohort of patients with oligodendrogliomas, all treated with radiotherapy +/− chemotherapy.
Journal ArticleDOI
Treatment Outcomes and Prognostic Factors in Patients with Low-Grade Glioma
TL;DR: Wang et al. as discussed by the authors evaluated the treatment outcomes and predictive factors for local control and overall survival in low-grade glioma patients, and they found that only type of radiotherapy (2D vs. 3D) has prognostic value for 2-year progression-free survival rates.
Journal ArticleDOI
Oncological and functional neurosurgery: Perspectives for the decade regarding diffuse gliomas.
TL;DR: In this article , the authors proposed a connectome-guided resection to minimize functional risks while maximizing the extent of resection, taking into account inter-individual brain anatomo-functional variability.
Book ChapterDOI
Chapter 12 – Brain Tumors
TL;DR: Amino acid PET may be helpful at primary diagnosis when MRI shows equivocal lesions; for planning biopsy, surgery, and radiation therapy owing to a better delineation of cerebral gliomas; after treatment to differentiate between tumor progression and treatment-related changes; and for monitoring of response to therapy.
References
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