Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
Jan C. Buckner,Edward G. Shaw,Stephanie L. Pugh,Arnab Chakravarti,Mark R. Gilbert,Geoffrey R. Barger,Stephen W. Coons,Peter Ricci,Dennis E. Bullard,Paul D. Brown,Keith J. Stelzer,David Brachman,John H. Suh,Christopher J. Schultz,Jean Paul Bahary,Barbara Fisher,Barbara Fisher,Harold Kim,Albert Murtha,Erica Hlavin Bell,Minhee Won,Minesh P. Mehta,Walter J. Curran +22 more
TLDR
In a cohort of patients with grade 2 glioma who were younger than 40 years of age and had undergone subtotal tumor resection or who were 40 yearsof age or older, progression-free survival and overall survival were longer among those who received combination chemotherapy in addition to radiation therapy than amongThose who received radiation therapy alone.Abstract:
BackgroundGrade 2 gliomas occur most commonly in young adults and cause progressive neurologic deterioration and premature death. Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), and vincristine after radiation therapy at the time of initial diagnosis resulted in longer progression-free survival, but not overall survival, than radiation therapy alone. We now report the long-term results. MethodsWe included patients with grade 2 astrocytoma, oligoastrocytoma, or oligodendroglioma who were younger than 40 years of age and had undergone subtotal resection or biopsy or who were 40 years of age or older and had undergone biopsy or resection of any of the tumor. Patients were stratified according to age, histologic findings, Karnofsky performance-status score, and presence or absence of contrast enhancement on preoperative images. Patients were randomly assigned to radiation therapy alone or to radiation therapy followed by six cycles of combination chemotherapy...read more
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Journal ArticleDOI
Evaluation of cost and survival in intracranial gliomas using the Value Driven Outcomes database: a retrospective cohort analysis.
Herschel Wilde,Mohammed A. Azab,Abdullah M. Abunimer,Hussam Abou-Al-Shaar,Michael Karsy,Jian Guan,Sarah T. Menacho,Randy L. Jensen +7 more
TL;DR: Adopting effective strategies that would reduce facility costs and limit LOS is likely the most important aspect in reducing intracranial glioma treatment costs, according to a retrospective cohort of patients treated at the authors’ institution.
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Benefit of adjuvant, but not concurrent, temozolomide for IDH-mutant anaplastic astrocytoma
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Implicações da radioterapia no tratamento do Glioma de baixo grau na odontologia: relato de caso
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TL;DR: Gliomas de baixo grau sao tumores cerebrais that afetam predominantemente adultos jovens com potencial de comprometimento da capacidade cognitiva, podendo levar a obito as mentioned in this paper.
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A 25-year retrospective, single center analysis of 343 WHO grade II/III glioma patients: implications for grading and temozolomide therapy.
Eike Steidl,Katharina Filipski,Pia S. Zeiner,Marlies Wagner,Emmanouil Fokas,Marie Therese Forster,Michael W. Ronellenfitsch,Iris Divé,Iris Divé,Joachim P. Steinbach,Patrick N. Harter,Oliver Bähr,Oliver Bähr +12 more
TL;DR: In this paper, the authors identified 343 patients (1995-2015) with newly diagnosed WHO grade II/III gliomas and analyzed molecular markers, patient characteristics, symptoms, histology, treatment, time to treatment failure (TTF) and OS IDH status for all patients (259 mutant, 84 IDH1-R132H-non-mutant) Molecular subclassification was possible in 173 tumors, resulting in diagnosis of 80 astrocytomas and 93 oligodendrogliomas.
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The Concept of Onco-Functional Balance in the Management of DLGG
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TL;DR: Nowadays, management of DLGG is conceptualized as a multi-stages therapeutic sequence of the different treatment modalities that are surgery, chemotherapy, radiation therapy and concomitant radio-chemotherapy.
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