Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
Jan C. Buckner,Edward G. Shaw,Stephanie L. Pugh,Arnab Chakravarti,Mark R. Gilbert,Geoffrey R. Barger,Stephen W. Coons,Peter Ricci,Dennis E. Bullard,Paul D. Brown,Keith J. Stelzer,David Brachman,John H. Suh,Christopher J. Schultz,Jean Paul Bahary,Barbara Fisher,Barbara Fisher,Harold Kim,Albert Murtha,Erica Hlavin Bell,Minhee Won,Minesh P. Mehta,Walter J. Curran +22 more
TLDR
In a cohort of patients with grade 2 glioma who were younger than 40 years of age and had undergone subtotal tumor resection or who were 40 yearsof age or older, progression-free survival and overall survival were longer among those who received combination chemotherapy in addition to radiation therapy than amongThose who received radiation therapy alone.Abstract:
BackgroundGrade 2 gliomas occur most commonly in young adults and cause progressive neurologic deterioration and premature death. Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), and vincristine after radiation therapy at the time of initial diagnosis resulted in longer progression-free survival, but not overall survival, than radiation therapy alone. We now report the long-term results. MethodsWe included patients with grade 2 astrocytoma, oligoastrocytoma, or oligodendroglioma who were younger than 40 years of age and had undergone subtotal resection or biopsy or who were 40 years of age or older and had undergone biopsy or resection of any of the tumor. Patients were stratified according to age, histologic findings, Karnofsky performance-status score, and presence or absence of contrast enhancement on preoperative images. Patients were randomly assigned to radiation therapy alone or to radiation therapy followed by six cycles of combination chemotherapy...read more
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Prognostic and predictive impact of MGMT promoter methylation status in high risk grade II glioma
TL;DR: The largest study to date demonstrating both the prognostic and predictive impact of MGMT methylation on patients with grade II glioma shows that mMGMT is a prognostic factor and possibly a predictive biomarker for grade IIglioma patients, and suggests that m MGMT is predictive.
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Changing paradigms for targeted therapies against diffuse infiltrative gliomas: tackling a moving target.
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Variations in the management of diffuse low-grade gliomas-A Scandinavian multicenter study.
Bodil Karoline Ravn Munkvold,Ole Solheim,Jiri Bartek,Jiri Bartek,Jiri Bartek,Alba Corell,Eddie de Dios,Eddie de Dios,Sasha Gulati,Eirik Helseth,Eirik Helseth,Klas Holmgren,Margret Jensdottir,Mina Lundborg,Eduardo Erasmo Mendoza Mireles,Ruby Mahesparan,Øystein Vesterli Tveiten,Øystein Vesterli Tveiten,Peter Milos,Henrietta Nittby Redebrandt,Lars Kjelsberg Pedersen,Jon Ramm-Pettersen,Rickard L. Sjöberg,Björn Sjögren,Kristin Sjåvik,Anja Smits,Gregor Tomasevic,Tomás Gómez Vecchio,Einar O. Vik-Mo,Einar O. Vik-Mo,Maria Zetterling,Maria Zetterling,Øyvind Salvesen,Asgeir Store Jakola +33 more
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Attitudes toward fertility and fertility preservation in women with glioma
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TL;DR: The data obtained in this study suggest a lack of understanding of reproductive priorities, which may be addressed with a more comprehensive fertility discussion prior to beginning treatment.
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Impact of the revised WHO classification of diffuse low-grade glioma on clinical decision making : A case report
Tim A. M. Bouwens van der Vlis,Ann Hoeben,Jan Beckervordersandforth,Linda Ackermans,Daniëlle B.P. Eekers,Rianne M J Wennekes,Olaf E. M. G. Schijns +6 more
TL;DR: The introduction of molecular parameters to the classification of LGG will add a level of objectivity, which will yield biological homogeneous subclasses and influence patient counseling and clinical decision making regarding treatment protocols.
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