Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
Jan C. Buckner,Edward G. Shaw,Stephanie L. Pugh,Arnab Chakravarti,Mark R. Gilbert,Geoffrey R. Barger,Stephen W. Coons,Peter Ricci,Dennis E. Bullard,Paul D. Brown,Keith J. Stelzer,David Brachman,John H. Suh,Christopher J. Schultz,Jean Paul Bahary,Barbara Fisher,Barbara Fisher,Harold Kim,Albert Murtha,Erica Hlavin Bell,Minhee Won,Minesh P. Mehta,Walter J. Curran +22 more
TLDR
In a cohort of patients with grade 2 glioma who were younger than 40 years of age and had undergone subtotal tumor resection or who were 40 yearsof age or older, progression-free survival and overall survival were longer among those who received combination chemotherapy in addition to radiation therapy than amongThose who received radiation therapy alone.Abstract:
BackgroundGrade 2 gliomas occur most commonly in young adults and cause progressive neurologic deterioration and premature death. Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), and vincristine after radiation therapy at the time of initial diagnosis resulted in longer progression-free survival, but not overall survival, than radiation therapy alone. We now report the long-term results. MethodsWe included patients with grade 2 astrocytoma, oligoastrocytoma, or oligodendroglioma who were younger than 40 years of age and had undergone subtotal resection or biopsy or who were 40 years of age or older and had undergone biopsy or resection of any of the tumor. Patients were stratified according to age, histologic findings, Karnofsky performance-status score, and presence or absence of contrast enhancement on preoperative images. Patients were randomly assigned to radiation therapy alone or to radiation therapy followed by six cycles of combination chemotherapy...read more
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Journal ArticleDOI
Revue de presse de l’AERIO
Journal ArticleDOI
Preoperative Patient-Reported Outcomes in Suspected Low-Grade Glioma: Markers of Disease Severity and Correlations with Molecular Subtypes.
Dongni Buvarp,Isabelle Rydén,Katharina S. Sunnerhagen,Thomas Olsson Bontell,Thomas Olsson Bontell,Tomás Gómez Vecchio,Anja Smits,Anja Smits,Asgeir Store Jakola +8 more
TL;DR: In this article, the overall health-related quality of life (HRQoL), functioning, fatigue, and psychological distress preoperatively in patients with suspected diffuse low-grade glioma (dLGG) were determined.
Journal ArticleDOI
Moderne Verfahren für die Strahlentherapie von Hirntumoren und Tumoren der Schädelbasis
TL;DR: Molekulare Eigenschaften von Tumoren bestimmen heute die Therapieentscheidung im interdisziplinaren Kontext sowohl fur primare als auch fur sekundare Hirntumoren.
Book ChapterDOI
Landmark Trials in Selected Central Nervous System Tumors
TL;DR: This chapter contains a summary of some key findings from a selection of 24 trials related to adult low- and high-grade glioma, meningiomas, and brain metastasis.
References
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Evaluation of survival data and two new rank order statistics arising in its consideration.
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Survival Analysis: Techniques for Censored and Truncated Data by
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