Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
Jan C. Buckner,Edward G. Shaw,Stephanie L. Pugh,Arnab Chakravarti,Mark R. Gilbert,Geoffrey R. Barger,Stephen W. Coons,Peter Ricci,Dennis E. Bullard,Paul D. Brown,Keith J. Stelzer,David Brachman,John H. Suh,Christopher J. Schultz,Jean Paul Bahary,Barbara Fisher,Barbara Fisher,Harold Kim,Albert Murtha,Erica Hlavin Bell,Minhee Won,Minesh P. Mehta,Walter J. Curran +22 more
TLDR
In a cohort of patients with grade 2 glioma who were younger than 40 years of age and had undergone subtotal tumor resection or who were 40 yearsof age or older, progression-free survival and overall survival were longer among those who received combination chemotherapy in addition to radiation therapy than amongThose who received radiation therapy alone.Abstract:
BackgroundGrade 2 gliomas occur most commonly in young adults and cause progressive neurologic deterioration and premature death. Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), and vincristine after radiation therapy at the time of initial diagnosis resulted in longer progression-free survival, but not overall survival, than radiation therapy alone. We now report the long-term results. MethodsWe included patients with grade 2 astrocytoma, oligoastrocytoma, or oligodendroglioma who were younger than 40 years of age and had undergone subtotal resection or biopsy or who were 40 years of age or older and had undergone biopsy or resection of any of the tumor. Patients were stratified according to age, histologic findings, Karnofsky performance-status score, and presence or absence of contrast enhancement on preoperative images. Patients were randomly assigned to radiation therapy alone or to radiation therapy followed by six cycles of combination chemotherapy...read more
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Journal ArticleDOI
The ability to return to work: a patient-centered outcome parameter following glioma surgery
Christian Senft,Marion Behrens,Irina Lortz,Katharina J. Wenger,Katharina Filipski,Volker Seifert,Marie-Therese Forster +6 more
TL;DR: The ability to resume professional activities following brain tumor surgery is an important patient-oriented outcome parameter and Multivariable regression analysis showed that patient age as well as occupational group and self-reported fatigue were factors independently associated with the ability to return to work.
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Neurocognitive function and quality of life after proton beam therapy for brain tumour patients.
Almut Dutz,Almut Dutz,L. Agolli,Rebecca Bütof,Chiara Valentini,Michael H. Baumann,Armin Lühr,Steffen Löck,Mechthild Krause +8 more
TL;DR: Self-reported and objectively measured neurocognition and most other QoL domains remained largely stable over time during recurrence-free follow-up for brain tumour patients treated with PBT, and the association between reduced cognitive function and irradiated volume of the anterior cerebellum requires validation in larger studies and comparison to patients treating with photon therapy.
Journal ArticleDOI
Survey on current practice within the European Low-Grade Glioma Network: where do we stand and what is the next step?
Emmanuel Mandonnet,Michel Wager,Fabien Almairac,Marie-Hélène Baron,Marie Blonski,Christian F. Freyschlag,Fabio Barone,Denys Fontaine,Johan Pallud,Monika E. Hegi,Catarina Pessanha Viegas,Maria Zetterling,Giannantonio Spena,John Goodden,Geert-Jan Rutten,Luc Taillandier,Nicolas Foroglu,Amélie Darlix,Miran Skrap,Juan Martino,Gord von Campe,Caterina Madadaki,Etienne Gayat,Philip C. De Witt Hamer,Santiago Gil Robles,Silvio Sarubbo,Thomas Santorius,Lorenzo Bello,Marie-Therese Forster,Hugues Duffau +29 more
TL;DR: This paper aimed to identify clinically relevant questions raised by this heterogeneity of practice in diffuse low-grade glioma management, to propose new methodological frameworks to address these questions.
Journal ArticleDOI
Histopathological grading affects survival in patients with IDH-mutant grade II and grade III diffuse gliomas.
Enrico Franceschi,Alicia Tosoni,Stefania Bartolini,S. Minichillo,Antonella Mura,Sofia Asioli,Daniela Bartolini,Marina Paola Gardiman,Marco Gessi,Claudio Ghimenton,Felice Giangaspero,Giovanni Lanza,Gianluca Marucci,Mariangela Novello,Enrico Maria Silini,Elena Zunarelli,Alexandro Paccapelo,Alba A. Brandes +17 more
TL;DR: In this study, histopathological grade still affects survival in IDH-mutant WHO grade II and III diffuse gliomas, and this effect appears to be independent from molecular features, extension of surgical resection and post-surgical treatments.
Journal ArticleDOI
Risk factors of radiotherapy‐induced cerebral microbleeds and serial analysis of their size compared with white matter changes: A 7T MRI study in 113 adult patients with brain tumors
Melanie A. Morrison,Christopher P. Hess,Jennifer Clarke,Nicholas Butowski,Susan M. Chang,Annette M. Molinaro,Janine M. Lupo +6 more
TL;DR: Although radiation therapy contributes to survival benefit in many brain tumor patients, it has also been associated with long‐term brain injury and Cerebral microbleeds represent an important manifestation of radiation‐related injury.
References
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