Regulation of the hematopoietic stem cell lifecycle by the endothelial niche.
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TLDR
ECs provide a fertile niche for maintenance of functional HSCs throughout their lifecycle and an improved understanding of the EC-HSC cross-talk will pave the way for development of EC-directed strategies for improving HSC function during aging.Abstract:
Purpose of reviewHematopoietic stem cells (HSCs) predominantly reside either in direct contact or in close proximity to the vascular endothelium throughout their lifespan. From the moment of HSC embryonic specification from hemogenic endothelium, endothelial cells (ECs) act as a critical cellular-huread more
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Haematopoietic stem cell activity and interactions with the niche.
Sandra Pinho,Paul S. Frenette +1 more
TL;DR: Advances in understanding of HSC regulation by niches during homeostasis, ageing and cancer are reviewed and their implications for the development of therapies to rejuvenate aged HSCs or niches or to disrupt self-reinforcing malignant niches are discussed.
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Ren Xu,Alisha R. Yallowitz,An Qin,Zhuhao Wu,Dong Yeon Shin,Jung-Min Kim,Shawon Debnath,Gang Ji,Gang Ji,Mathias P.G. Bostrom,Xu Yang,Chao Zhang,Han Dong,Han Dong,Pouneh Kermani,Sarfaraz Lalani,Na Li,Yifang Liu,Michael G. Poulos,Amanda Wach,Yi Zhang,Kazuki Inoue,Kazuki Inoue,Annarita Di Lorenzo,Baohong Zhao,Baohong Zhao,Jason M. Butler,Jae-Hyuck Shim,Laurie H. Glimcher,Laurie H. Glimcher,Matthew B. Greenblatt +30 more
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Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression
Peipei Guo,Michael G. Poulos,Brisa Palikuqi,Chaitanya R. Badwe,Raphael Lis,Balvir Kunar,Bi-Sen Ding,Sina Y. Rabbany,Sina Y. Rabbany,Koji Shido,Jason M. Butler,Shahin Rafii +11 more
TL;DR: It is shown that under steady state, jagged-2 is differentially expressed in tissue-specific vascular beds, but its expression is induced in hematopoietic vascular niches after myelosuppressive injury.
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Bone Marrow Mononuclear Cells Activate Angiogenesis via Gap Junction-Mediated Cell-Cell Interaction
Akie Kikuchi-Taura,Yuka Okinaka,Yukiko Takeuchi,Yuko Ogawa,Mitsuyo Maeda,Yosky Kataoka,Teruhito Yasui,Takafumi Kimura,Sheraz Gul,Carsten Claussen,Johannes Boltze,Akihiko Taguchi +11 more
TL;DR: Cell-cell interaction via gap junction is the prominent pathway for activation of angiogenesis at endothelial cells after ischemia and provided novel paradigm that energy source supply by stem cell to injured cell is one of the therapeutic mechanisms of cell-based therapy.
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Obesity-Induced Changes in Bone Marrow Homeostasis.
Andrea Benova,Michaela Tencerova +1 more
TL;DR: This review summarizes recent findings on inflammatory and cellular changes in the bone marrow in relation to obesity and further discusses whether dietary intervention or physical activity may have beneficial effects on theBone marrow microenvironment and whole-body metabolism.
References
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Journal ArticleDOI
Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
Journal ArticleDOI
Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
Journal ArticleDOI
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Simón Méndez-Ferrer,Tatyana V. Michurina,Francesca Ferraro,Amin R. Mazloom,Ben D. MacArthur,Ben D. MacArthur,Sergio A. Lira,David T. Scadden,Avi Ma'ayan,Grigori Enikolopov,Paul S. Frenette,Paul S. Frenette +11 more
TL;DR: It is demonstrated that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs.
Journal ArticleDOI
Identification of the haematopoietic stem cell niche and control of the niche size
Jiwang Zhang,Chao Niu,Ling Ye,Haiyang Huang,Xi C. He,Wei Gang Tong,Jason Ross,Jeffrey S. Haug,Teri Johnson,Jian Q. Feng,Stephen E. Harris,Leanne M. Wiedemann,Leanne M. Wiedemann,Yuji Mishina,Linheng Li,Linheng Li +15 more
TL;DR: It is concluded that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of H SCs by regulating niche size.
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