Resveratrol and health – A comprehensive review of human clinical trials
TLDR
The current state of knowledge on the effects of resveratrol on humans is examined to utilize this information to develop further guidelines for the implementation of human clinical trials.Abstract:
In the past decade, the small polyphenol resveratrol has received widespread attention as either a potential therapy or as a preventive agent for numerous diseases. Studies using purified enzymes, cultured cells, and laboratory animals have suggested that resveratrol has anti-aging, anti-carcinogenic, anti-inflammatory, and anti-oxidant properties that might be relevant to chronic diseases and/or longevity in humans. Although the supporting research in laboratory models is quite substantial, only recently data has emerged to describe the effects of resveratrol supplementation on physiological responses in humans. The limited number of human clinical trials that are available has largely described various aspects of resveratrol's safety and bioavailability, reaching a consensus that it is generally well-tolerated, but have poor bioavailability. Very few published human studies have explored the ability of resveratrol to achieve the physiological benefits that have been observed in laboratory models, although many clinical trials have recently been initiated. This review aims to examine the current state of knowledge on the effects of resveratrol on humans and to utilize this information to develop further guidelines for the implementation of human clinical trials.read more
Citations
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Phytoalexins in defense against pathogens
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Small molecule SIRT1 activators for the treatment of aging and age-related diseases
TL;DR: The fact that two-thirds of people in the USA who consume multiple dietary supplements consume resveratrol, a SIRT1 activator, underscores the importance of understanding the biochemical mechanism, physiological effects, and safety of STACs.
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Interventions to Slow Aging in Humans: Are We Ready?
Valter D. Longo,Adam Antebi,Andrzej Bartke,Nir Barzilai,Holly M. Brown-Borg,Calogero Caruso,Tyler J. Curiel,Rafael de Cabo,Claudio Franceschi,David Gems,Donald K. Ingram,Thomas E. Johnson,Brian K. Kennedy,Cynthia Kenyon,Samuel Klein,John J. Kopchick,G Lepperdinger,Frank Madeo,Mario G. Mirisola,James R. Mitchell,Giuseppe Passarino,Karl Lenhard Rudolph,John M. Sedivy,Gerald S. Shadel,David A. Sinclair,David A. Sinclair,Stephen R. Spindler,Yousin Suh,Jan Vijg,Manlio Vinciguerra,Luigi Fontana,Luigi Fontana +31 more
TL;DR: There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age and their potential to be safe and effective in extending human healthspan.
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High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition
Morten Poulsen,P. Vestergaard,Berthil F. Clasen,Yulia Radko,Lars Porskjær Christensen,Hans Stødkilde-Jørgensen,Niels Møller,Niels Jessen,Steen B. Pedersen,Jens Otto Lunde Jørgensen +9 more
TL;DR: The lack of effect disagrees with persuasive data obtained from rodent models and raises doubt about the justification of resveratrol as a human nutritional supplement in metabolic disorders.
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Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence.
Joao Tomé-Carneiro,Mar Larrosa,Antonio González-Sarrías,Francisco A. Tomás-Barberán,María Teresa García-Conesa,Juan Carlos Espín +5 more
TL;DR: This review will focus on the currently available evidence regarding resveratrol’s effects on humans obtained from randomized clinical trials and provide a critical outlook for further research on this molecule that is evolving from a minor dietary compound to a possible multi-target therapeutic drug.
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TL;DR: A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.
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