RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis.
TLDR
A multinational registry analysis of the use of hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19 found each drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmia during hospitalisation.About:
This article is published in The Lancet.The article was published on 2020-06-13 and is currently open access. It has received 963 citations till now. The article focuses on the topics: Hydroxychloroquine.read more
Citations
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A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19.
David R. Boulware,Matthew F Pullen,Ananta S. Bangdiwala,Katelyn A Pastick,Sarah M Lofgren,Elizabeth C Okafor,Caleb P Skipper,Alanna A Nascene,Melanie R. Nicol,Mahsa Abassi,Nicole W. Engen,Matthew P. Cheng,Derek LaBar,Sylvain A. Lother,Lauren J. MacKenzie,Glen Drobot,Nicole Marten,Ryan Zarychanski,Lauren E. Kelly,Ilan S. Schwartz,Emily G. McDonald,Radha Rajasingham,Todd C. Lee,Kathy H. Hullsiek +23 more
TL;DR: After high-risk or moderate-risk exposure to Covid-19, hydroxychloroquine did not prevent illness compatible with Covid -19 or confirmed infection when used as postexposure prophylaxis within 4 days after exposure.
Journal ArticleDOI
Outcomes of Hydroxychloroquine Usage in United States Veterans Hospitalized with COVID-19.
Joseph Magagnoli,Siddharth Narendran,Felipe Pereira,Tammy H. Cummings,James W. Hardin,S Scott Sutton,Jayakrishna Ambati +6 more
TL;DR: Among patients hospitalized with COVID-19, this retrospective study did not identify any significant reduction in mortality or in the need for mechanical ventilation with hydroxychloroquine treatment with or without azithromycin.
Journal ArticleDOI
Out-of-hospital cardiac arrest during the COVID-19 pandemic in Paris, France: a population-based, observational study.
Eloi Marijon,Nicole Karam,Daniel Jost,David Perrot,Benoit Frattini,Clément Derkenne,Ardalan Sharifzadehgan,Victor Waldmann,Frankie Beganton,Kumar Narayanan,Antoine Lafont,Wulfran Bougouin,Xavier Jouven +12 more
TL;DR: The incidence and outcomes of out-of-hospital cardiac arrest (OHCA) in an urban region during the pandemic, compared with non-pandemic periods was evaluated in adult inhabitants of the study area.
Journal ArticleDOI
Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19).
Srikanth Umakanthan,Pradeep Kumar Sahu,Anu V. Ranade,Maryann M Bukelo,Joseph Sushil Rao,Lucas Faria Abrahão-Machado,Samarika Dahal,Hari Kumar,Dhananjaya Kv +8 more
TL;DR: The current state of knowledge concerning the origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19) is reviewed, believed to be acquired from zoonotic source and spreads through direct and contact transmission.
Journal ArticleDOI
The National COVID Cohort Collaborative (N3C): Rationale, Design, Infrastructure, and Deployment.
Melissa A. Haendel,Melissa A. Haendel,Christopher G. Chute,Tellen D. Bennett,David Eichmann,Justin Guinney,Warren A. Kibbe,Philip R. O. Payne,Emily R. Pfaff,Peter N. Robinson,Joel H. Saltz,Heidi Spratt,Christine Suver,John Wilbanks,Adam B. Wilcox,Andrew E. Williams,Chunlei Wu,Clair Blacketer,Robert L. Bradford,James J. Cimino,Marshall Clark,Evan W Colmenares,Patricia A Francis,Davera Gabriel,Alexis Graves,Raju Hemadri,Stephanie S Hong,George Hripscak,Dazhi Jiao,Jeffrey G. Klann,Kristin Kostka,Adam M Lee,Harold P Lehmann,Lora Lingrey,Robert T. Miller,Michele I. Morris,Shawn N. Murphy,Karthik Natarajan,Matvey B. Palchuk,Usman Sheikh,Harold R. Solbrig,Shyam Visweswaran,Anita Walden,Anita Walden,Kellie M Walters,Griffin M. Weber,Xiaohan Tanner Zhang,Richard L Zhu,Benjamin Amor,Andrew T Girvin,Amin Manna,Nabeel Qureshi,Michael G. Kurilla,Sam Michael,Lili M Portilla,Joni L Rutter,Christopher P. Austin,Ken R Gersing +57 more
TL;DR: The N3C has demonstrated that a multisite collaborative learning health network can overcome barriers to rapidly build a scalable infrastructure incorporating multiorganizational clinical data for COVID-19 analytics.
References
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Journal ArticleDOI
Endothelial cell infection and endotheliitis in COVID-19.
Zsuzsanna Varga,Andreas J. Flammer,Peter Steiger,Martina Haberecker,Rea Andermatt,Annelies S. Zinkernagel,Mandeep R. Mehra,Reto A. Schuepbach,Frank Ruschitzka,Holger Moch +9 more
TL;DR: The vascular endothelium is an active paracrine, endocrine, and Endothelial cell infection and endotheliitis in COVID-19 and recruitment of immune cells can result in widespread endothelial dysfunction associated with apoptosis.
Journal ArticleDOI
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
Philippe Gautret,Jean-Christophe Lagier,Philippe Parola,Van Thuan Hoang,Line Meddeb,M. Mailhe,Barbara Doudier,Johan Courjon,Valérie Giordanengo,Vera Esteves Vieira,Hervé Tissot Dupont,Stéphane Honoré,Philippe Colson,Eric Chabrière,Bernard La Scola,Jean-Marc Rolain,Philippe Brouqui,Didier Raoult +17 more
TL;DR: Hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin, which was significantly more efficient for virus elimination.
Journal ArticleDOI
Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China.
Shaobo Shi,Mu Qin,Bo Shen,Yuli Cai,Tao Liu,Fan Yang,Wei Gong,Xu Liu,Jinjun Liang,Qinyan Zhao,He Huang,Bo Yang,Congxin Huang +12 more
TL;DR: The association between cardiac injury and mortality in patients with COVID-19 was analyzed and it was found that patients with cardiac injury had a higher proportion of multiple mottling and ground-glass opacity in radiographic findings than those without cardiac injury.
Journal ArticleDOI
Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19).
Tao Guo,Yongzhen Fan,Ming Chen,Xiaoyan Wu,Lin Zhang,Tao He,Hairong Wang,Jing Wan,Xinghuan Wang,Zhibing Lu +9 more
TL;DR: This case series study evaluates the association of underlying cardiovascular disease and myocardial injury on fatal outcomes in patients with coronavirus disease 2019 (COVID-19).
Journal ArticleDOI
Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.
Jianjun Gao,Zhenxue Tian,Xu Yang +2 more
TL;DR: Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China.
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