Journal ArticleDOI
Stress and the brain: from adaptation to disease
TLDR
In response to stress, the brain activates several neuropeptide-secreting systems, which eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators as mentioned in this paper.Abstract:
In response to stress, the brain activates several neuropeptide-secreting systems. This eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators. By targeting many genes, corticosteroids function in a binary fashion, and serve as a master switch in the control of neuronal and network responses that underlie behavioural adaptation. In genetically predisposed individuals, an imbalance in this binary control mechanism can introduce a bias towards stress-related brain disease after adverse experiences. New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified.read more
Citations
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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Patrick O. McGowan,Aya Sasaki,Aya Sasaki,Ana C. D'Alessio,Sergiy Dymov,Benoit Labonté,Moshe Szyf,Gustavo Turecki,Michael J. Meaney,Michael J. Meaney +9 more
TL;DR: Findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
Journal ArticleDOI
The molecular neurobiology of depression
TL;DR: Recent studies combining behavioural, molecular and electrophysiological techniques reveal that certain aspects of depression result from maladaptive stress-induced neuroplastic changes in specific neural circuits and show that understanding the mechanisms of resilience to stress offers a crucial new dimension for the development of fundamentally novel antidepressant treatments.
Journal ArticleDOI
About sleep's role in memory
Bjoern Rasch,Jan Born,Jan Born +2 more
TL;DR: This review aims to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a discussion of more recent key findings.
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Major depressive disorder.
Robert H. Belmaker,Galila Agam +1 more
TL;DR: This review presents the major current approaches to understanding the biologic mechanisms of major depression and defines depression as a heterogeneous disorder with a highly variable course, an inconsistent response to treatment, and no established mechanism.
Journal ArticleDOI
New approaches to antidepressant drug discovery: beyond monoamines
Olivier Berton,Eric J. Nestler +1 more
TL;DR: A recent review summarizes the obstacles that have hindered the development of non-monoamine-based antidepressants, and provides a progress report on some of the most promising current strategies as discussed by the authors.
References
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Journal Article
Antidepressant drug action in a transgenic mouse model of the endocrine changes seen in depression.
TL;DR: Treatment of transgenic mouse lines with the tricyclic antidepressant desipramine increased hypothalamic glucocorticoid receptor mRNA concentration and dexamethasone-binding activity while decreasing plasma adrenocortiotropin hormone concentration and corticosterone levels, which support the hypothesis that antidepressants exert action on the hypothalamic-pituitary-adrenal axis through modulation of glucoc Corticoid receptors gene expression.
Journal ArticleDOI
Effect of Chronic Stress on Synaptic Currents in Rat Hippocampal Dentate Gyrus Neurons
Henk Karst,Marian Joëls +1 more
TL;DR: In this paper, the effect of chronic stress on synaptic responses of rat dentate granule cells to perforant path stimulation was investigated, where rats were subjected for 3 wk to unpredictable stressors twice daily or...
Journal ArticleDOI
Neurochemical and behavioral alterations in glucocorticoid receptor-impaired transgenic mice after chronic mild stress.
Nicolas Froger,Enza Palazzo,Claudette Boni,Naïma Hanoun,Françoise Saurini,Chantal Joubert,Isabelle Dutriez-Casteloot,Michaela Enache,Stefania Maccari,Nicholas Barden,Charles Cohen-Salmon,Michel Hamon,Laurence Lanfumey +12 more
TL;DR: Assessment of the effects of a 4 week chronic mild stress on the HPA axis and 5-HT system and the serotoninergic system in a transgenic model of vulnerability to affective disorders demonstrates that impaired GR functioning affects normal adaptive responses of the H PA axis and5-HTSystem and alters stress-related consequences on decision-making behaviors.
Journal ArticleDOI
Rapid reversal of acute psychosis in the Cushing syndrome with the cortisol-receptor antagonist mifepristone (RU 486).
TL;DR: The progesterone-receptor antagonist, RU 486 (mifepristone), is also, at higher concentrations, an effective antagonist of glucocorticoid action in vitro and in vivo.
Journal ArticleDOI
Effects of inescapable stress on LTP in the amygdala versus the dentate gyrus of freely behaving rats.
TL;DR: The ability of entorhinal cortex stimulation to induce LTP simultaneously in the basal amygdaloid nucleus (B) and in the dentate gyrus (DG) of freely behaving Wistar rats and the effects of acute vs. repeated inescapable stressful experiences on LTP in both structures support a role for B in memory storage.