Journal ArticleDOI
Stress and the brain: from adaptation to disease
TLDR
In response to stress, the brain activates several neuropeptide-secreting systems, which eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators as mentioned in this paper.Abstract:
In response to stress, the brain activates several neuropeptide-secreting systems. This eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators. By targeting many genes, corticosteroids function in a binary fashion, and serve as a master switch in the control of neuronal and network responses that underlie behavioural adaptation. In genetically predisposed individuals, an imbalance in this binary control mechanism can introduce a bias towards stress-related brain disease after adverse experiences. New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified.read more
Citations
More filters
Journal ArticleDOI
The modulatory role of the lateral septum on neuroendocrine and behavioral stress responses.
TL;DR: The data suggest that the LS promotes active stress coping behavior and is involved in a HPA-inhibitory mechanism that is at least in part mediated by septal 5-HT1A receptors and does not involve a glucocorticoid mediated feedback mechanism.
Journal ArticleDOI
How the brain connects in response to acute stress: A review at the human brain systems level
J. van Oort,Indira Tendolkar,Erno J. Hermans,Peter F.A. Mulders,Christian F. Beckmann,Aart H. Schene,Guillén Fernández,P.F.P. van Eijndhoven +7 more
TL;DR: This work sets out to review commonalities and diversities of the stress‐related functional activity and connectivity changes of functional brain networks in healthy adults across procedures and confirms earlier findings of an essential, coordinating role of the SN in the acute stress response and indicates a dynamic roles of the DMN whose function is less clear.
Journal ArticleDOI
Th2 cytokine response in Major Depressive Disorder patients before treatment
Lenin Pavón,Gabriel Sandoval-López,María Eugenia Hernández,Frida Loría,Iris Estrada,Mayra Perez,Julia Moreno,Ulises Ávila,Philippe Leff,Benito Antón,Gerhard Heinze +10 more
TL;DR: It is proposed that the changes observed in the pro/anti-inflammatory Th1/Th2 cytokine balance in MDD patients and in non-depressed control group could be related to the elevated cortisol levels seen in the patients.
Journal ArticleDOI
Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia.
Tiffany F. Hughes,Mary Ganguli +1 more
TL;DR: Recommendations and challenges for developing effective strategies to reduce the burden of cognitive impairment and dementia in the future are discussed.
Journal ArticleDOI
Corticosterone alters AMPAR mobility and facilitates bidirectional synaptic plasticity.
Stéphane Martin,Jeremy M. Henley,David Holman,Ming Zhou,Olof Wiegert,Myrrhe van Spronsen,Marian Joëls,Casper C. Hoogenraad,Harmen J. Krugers +8 more
TL;DR: The results reveal that corticosterone increases mobile GluR2 containing AMPARs and this action may underlie both the facilitating and suppressive effects of corticosteroid hormones on synaptic plasticity and learning and memory.
References
More filters
Journal ArticleDOI
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
TL;DR: Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
Journal ArticleDOI
How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
Journal ArticleDOI
Epigenetic programming by maternal behavior.
Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
TL;DR: It is shown that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible, suggesting a causal relation among epigenomicState, GR expression and the maternal effect on stress responses in the offspring.
Journal ArticleDOI
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
Luca Santarelli,Michael Saxe,Cornelius Gross,Alexandre Surget,Fortunato Battaglia,Stephanie C. Dulawa,Noelia V. Weisstaub,James T. Lee,Ronald S. Duman,Ottavio Arancio,Catherine Belzung,René Hen +11 more
TL;DR: It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
Journal ArticleDOI
A Syndrome produced by Diverse Nocuous Agents
TL;DR: If the organism is severely damaged by acute non-specific nocuous agents such as exposure to cold, surgical injury, production of spinal shock, excessive muscular exercise, or intoxications with sublethal doses of diverse drugs, a typical syndrome appears, the symptoms of which are independent of the nature of the damaging agent or the pharmacological type of the drug employed.