Journal ArticleDOI
Stress and the brain: from adaptation to disease
TLDR
In response to stress, the brain activates several neuropeptide-secreting systems, which eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators as mentioned in this paper.Abstract:
In response to stress, the brain activates several neuropeptide-secreting systems. This eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators. By targeting many genes, corticosteroids function in a binary fashion, and serve as a master switch in the control of neuronal and network responses that underlie behavioural adaptation. In genetically predisposed individuals, an imbalance in this binary control mechanism can introduce a bias towards stress-related brain disease after adverse experiences. New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified.read more
Citations
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The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
TL;DR: Understanding of the mechanisms by which stress and glucocorticoids affect glutamate transmission provides insights into normal brain functioning, as well as the pathophysiology and potential new treatments of stress-related neuropsychiatric disorders.
Journal ArticleDOI
Psychobiology and molecular genetics of resilience.
TL;DR: Research has shown that resilience is mediated by adaptive changes in several neural circuits involving numerous neurotransmitter and molecular pathways, which shape the functioning of the neural circuits that regulate reward, fear, emotion reactivity and social behaviour.
Journal ArticleDOI
Pathophysiology of Migraine: A Disorder of Sensory Processing
Peter J. Goadsby,Philip R. Holland,Margarida Martins-Oliveira,Jan Hoffmann,Christoph J. Schankin,Simon Akerman +5 more
TL;DR: Investment in understanding migraine leaves us at a new dawn, able to transform its impact on a global scale, as well as understand fundamental aspects of human biology.
Journal ArticleDOI
Neurobiology of Resilience
TL;DR: A growing literature in rodents is highlighted that is starting to complement the human work by identifying the active behavioral, neural, molecular and hormonal basis of resilience, which can pave the way for an innovative approach to drug development for a range of stress-related syndromes.
Journal ArticleDOI
Learning under stress: how does it work?
TL;DR: A unifying theory is proposed, which states that stress will only facilitate learning and memory processes when stress is experienced in the context and around the time of the event that needs to be remembered.
References
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Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
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A Syndrome produced by Diverse Nocuous Agents
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