Journal ArticleDOI
Stress and the brain: from adaptation to disease
TLDR
In response to stress, the brain activates several neuropeptide-secreting systems, which eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators as mentioned in this paper.Abstract:
In response to stress, the brain activates several neuropeptide-secreting systems. This eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators. By targeting many genes, corticosteroids function in a binary fashion, and serve as a master switch in the control of neuronal and network responses that underlie behavioural adaptation. In genetically predisposed individuals, an imbalance in this binary control mechanism can introduce a bias towards stress-related brain disease after adverse experiences. New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified.read more
Citations
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Biological Mechanisms Underlying the Role of Physical Fitness in Health and Resilience
TL;DR: The mechanisms whereby physical fitness promotes increased resilience and well-being and positive psychological and physical health are diverse and complex.
Journal ArticleDOI
Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress
Manuella P. Kaster,Manuella P. Kaster,Nuno J. Machado,Henrique B. Silva,Ana Nunes,Ana Paula Ardais,Ana Paula Ardais,Magda M. Santana,Younis Baqi,Younis Baqi,Christa E. Müller,Ana Lúcia S. Rodrigues,Lisiane O. Porciúncula,Jiang-Fan Chen,Ângelo R. Tomé,Paula Agostinho,Paula M. Canas,Rodrigo A. Cunha +17 more
TL;DR: It is shown that caffeine prevents the maladaptive changes caused by CUS in a manner mimicked by the selective blockade of adenosine A2A receptors (A2AR), suggesting A2AR as candidate targets to alleviate the consequences of chronic stress on brain function.
Journal ArticleDOI
MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34
Sharon Haramati,Inbal Livni Navon,Orna Issler,Gili Ezra-Nevo,Shosh Gil,Raaya Zwang,Eran Hornstein,Alon Chen +7 more
TL;DR: A physiological role for microRNAs in regulating the central stress response is suggested and they are position them as potential targets for treatment of stress-related disorders.
Journal ArticleDOI
Pubertal maturation and programming of hypothalamic-pituitary-adrenal reactivity.
TL;DR: The present review is to discuss the current understanding of how pubertal development and stress interact to affect the hypothalamic-pituitary-adrenal (HPA) axis, the major neuroendocrine axis that controls the hormonal stress response.
Journal ArticleDOI
Glucocorticoid actions on synapses, circuits, and behavior: implications for the energetics of stress.
TL;DR: This review summarizes the latest developments in central glucocorticoid actions on synaptic, neuroendocrine, and behavioral regulation in terms of the energetic integration of stress and the importance of context-specific regulation of glucOCorticoids.
References
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Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
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Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
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Journal ArticleDOI
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
Luca Santarelli,Michael Saxe,Cornelius Gross,Alexandre Surget,Fortunato Battaglia,Stephanie C. Dulawa,Noelia V. Weisstaub,James T. Lee,Ronald S. Duman,Ottavio Arancio,Catherine Belzung,René Hen +11 more
TL;DR: It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
Journal ArticleDOI
A Syndrome produced by Diverse Nocuous Agents
TL;DR: If the organism is severely damaged by acute non-specific nocuous agents such as exposure to cold, surgical injury, production of spinal shock, excessive muscular exercise, or intoxications with sublethal doses of diverse drugs, a typical syndrome appears, the symptoms of which are independent of the nature of the damaging agent or the pharmacological type of the drug employed.