Journal ArticleDOI
Stress and the brain: from adaptation to disease
TLDR
In response to stress, the brain activates several neuropeptide-secreting systems, which eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators as mentioned in this paper.Abstract:
In response to stress, the brain activates several neuropeptide-secreting systems. This eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators. By targeting many genes, corticosteroids function in a binary fashion, and serve as a master switch in the control of neuronal and network responses that underlie behavioural adaptation. In genetically predisposed individuals, an imbalance in this binary control mechanism can introduce a bias towards stress-related brain disease after adverse experiences. New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified.read more
Citations
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Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain
T. Rouwette,K. Klemann,Balázs Gaszner,Balázs Gaszner,G.J. Scheffer,Eric W. Roubos,Wim J.J.M. Scheenen,Kris Vissers,Tamas Kozicz +8 more
TL;DR: The hypothesis that each of the four brain centers responds to APS with CRF/Ucn1 dynamics that are specific as to nature and timing is supported, which proposes that CRF in the PVN plays a major role in the initiation phase, whereas Ucn1 in the npEW may act in the later, termination phase of the adaptation response toAPS.
Journal ArticleDOI
Molecular regulation of the hypothalamic‐pituitary‐adrenal axis in adult male guinea pigs after prenatal stress at different stages of gestation
TL;DR: It is demonstrated that short periods of prenatal stress during critical windows of neuroendocrine development affect the expression of key regulators of HPA axis activity leading to the changes in endocrine function observed in prenatally stressed male offspring.
Journal ArticleDOI
Wetlands for wellbeing: piloting a nature-based health intervention for the management of anxiety and depression
Phoebe R. Maund,Phoebe R. Maund,Katherine N. Irvine,Jonathan P. Reeves,Emily A Strong,Ruth L. Cromie,Martin Dallimer,Zoe G. Davies +7 more
TL;DR: NBIs based in wetlands are proposed as an effective therapy option for individuals diagnosed with anxiety and/or depression, and demonstrate significant improvements in mental health across a range of indicators.
Journal ArticleDOI
Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor
Jakob Hartmann,Nina Dedic,Max L. Pöhlmann,Alexander S. Häusl,Henk Karst,Clara Engelhardt,Sören Westerholz,Klaus V. Wagner,Christiana Labermaier,Lianne Hoeijmakers,M Kertokarijo,Alon Chen,Marian Joëls,Jan M. Deussing,Mathias V. Schmidt +14 more
TL;DR: A major contribution of GRs in the brain’s key excitatory, but not inhibitory, neurotransmitter system in the regulation of fear and anxiety behaviors is revealed, which is crucial to the understanding of the molecular mechanisms underlying anxiety disorders.
Journal ArticleDOI
Glucocorticoid and Mineralocorticoid Receptors in the Brain : A Transcriptional Perspective
TL;DR: In this article, the authors discuss proven and potential mechanisms of transcriptional specificity for mineralocorticoid receptors (MRs and GRs) and discuss specific interactions with transcriptional coregulators.
References
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Journal ArticleDOI
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
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Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
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Journal ArticleDOI
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
Luca Santarelli,Michael Saxe,Cornelius Gross,Alexandre Surget,Fortunato Battaglia,Stephanie C. Dulawa,Noelia V. Weisstaub,James T. Lee,Ronald S. Duman,Ottavio Arancio,Catherine Belzung,René Hen +11 more
TL;DR: It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
Journal ArticleDOI
A Syndrome produced by Diverse Nocuous Agents
TL;DR: If the organism is severely damaged by acute non-specific nocuous agents such as exposure to cold, surgical injury, production of spinal shock, excessive muscular exercise, or intoxications with sublethal doses of diverse drugs, a typical syndrome appears, the symptoms of which are independent of the nature of the damaging agent or the pharmacological type of the drug employed.