Journal ArticleDOI
Stress and the brain: from adaptation to disease
TLDR
In response to stress, the brain activates several neuropeptide-secreting systems, which eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators as mentioned in this paper.Abstract:
In response to stress, the brain activates several neuropeptide-secreting systems. This eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators. By targeting many genes, corticosteroids function in a binary fashion, and serve as a master switch in the control of neuronal and network responses that underlie behavioural adaptation. In genetically predisposed individuals, an imbalance in this binary control mechanism can introduce a bias towards stress-related brain disease after adverse experiences. New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified.read more
Citations
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Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines
Glenda Gillies,Simon McArthur +1 more
TL;DR: This review focuses on sex dimorphisms in the ability of estradiol to influence synaptic plasticity, neurotransmission, neurodegeneration, and cognition, which, it is argued, are due in a large part to sex differences in the organization of the underlying circuitry.
Journal ArticleDOI
Hair cortisol, stress exposure, and mental health in humans: A systematic review
Sabine M. Staufenbiel,Brenda W.J.H. Penninx,Anne T. Spijker,Bernet M. Elzinga,Bernet M. Elzinga,Elisabeth F.C. van Rossum +5 more
TL;DR: A first implication is made that the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in the development and/or maintenance of psychopathology may be more subtle than it is in healthy but chronically stressed populations.
Journal ArticleDOI
Stress and memory: behavioral effects and neurobiological mechanisms.
TL;DR: High stress levels, whether intrinsic or extrinsic, tend to facilitate Pavlovian conditioning (in a linear-asymptotic manner), while being deleterious for spatial/explicit information processing (which with regard to intrinsic stress levels follows an inverted U-shape effect).
Journal ArticleDOI
The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress
TL;DR: It is demonstrated that short periods of stress exposure induce spatial reference memory deficits before affecting PFC-dependent tasks, thus suggesting that the impairment of synaptic plasticity within the hippocampus-to-PFC connection is of relevance to the stress-induced PFC dysfunction.
Journal ArticleDOI
Acute psychological stress reduces working memory-related activity in the dorsolateral prefrontal cortex.
TL;DR: It is demonstrated that experimentally induced acute stress in healthy volunteers results in a reduction of WM-related DLPFC activity and reallocation of neural resources away from executive function networks, which may be explained by supraoptimal levels of catecholamines potentially in conjunction with elevated levels of cortisol.
References
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Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
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Journal ArticleDOI
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
Luca Santarelli,Michael Saxe,Cornelius Gross,Alexandre Surget,Fortunato Battaglia,Stephanie C. Dulawa,Noelia V. Weisstaub,James T. Lee,Ronald S. Duman,Ottavio Arancio,Catherine Belzung,René Hen +11 more
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Journal ArticleDOI
A Syndrome produced by Diverse Nocuous Agents
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