Journal ArticleDOI
Stress and the brain: from adaptation to disease
TLDR
In response to stress, the brain activates several neuropeptide-secreting systems, which eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators as mentioned in this paper.Abstract:
In response to stress, the brain activates several neuropeptide-secreting systems. This eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators. By targeting many genes, corticosteroids function in a binary fashion, and serve as a master switch in the control of neuronal and network responses that underlie behavioural adaptation. In genetically predisposed individuals, an imbalance in this binary control mechanism can introduce a bias towards stress-related brain disease after adverse experiences. New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified.read more
Citations
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Facilitation of endocannabinoid effects in the ventral hippocampus modulates anxiety-like behaviors depending on previous stress experience.
TL;DR: Results suggest that facilitation of endocannabinoid system neurotransmission in the ventral hippocampus modulates anxiety-like behaviors and that this effect depends on previous stress experience.
Journal ArticleDOI
Genome-wide coexpression of steroid receptors in the mouse brain: Identifying signaling pathways and functionally coordinated regions.
Ahmed Mahfouz,Ahmed Mahfouz,Boudewijn P. F. Lelieveldt,Boudewijn P. F. Lelieveldt,Aldo Grefhorst,Lisa T C M van Weert,Isabel M. Mol,Hetty C M Sips,José K. van den Heuvel,Nicole A. Datson,Jenny A. Visser,Marcel J. T. Reinders,Onno C. Meijer +12 more
TL;DR: The idea that novel aspects of steroid action can be identified through spatial correlation of steroid receptors with genome-wide mRNA expression across different regions in the mouse brain is tested and constitutes a rich resource for further predictions and understanding of brain modulation by steroid hormones.
Journal ArticleDOI
Glucocorticoids and Hippocampal Structure and Function in PTSD.
TL;DR: The available evidence is consistent with the possibility that smaller hippocampal volume may be a vulnerability factor for developing the disorder, and the need to integrate findings of glucocorticoid abnormalities with functional-imaging paradigms to formulate a comprehensive model of HPA-axis functioning in PTSD is described.
Journal ArticleDOI
Modulation of spatial and stimulus–response learning strategies by exogenous cortisol in healthy young women
TL;DR: It is demonstrated that exogenous GCs prior to learning affect the performance within a memory system and also coordinate the use of multiple memory systems, contributing to a better understanding of stress (hormone) effects on learning and memory.
Journal ArticleDOI
Association of FKBP5 gene haplotypes with completed suicide in the Japanese population
Irwan Supriyanto,Toru Sasada,Masaaki Fukutake,Migiwa Asano,Yasuhiro Ueno,Yasushi Nagasaki,Osamu Shirakawa,Akitoyo Hishimoto +7 more
TL;DR: The results suggest that haplotypes in FKBP5 gene are associated with completed suicide, and this finding needs to be confirmed using rigorous SNPs selection in a larger sample.
References
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Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
Journal ArticleDOI
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Ian C. G. Weaver,Nadia Cervoni,Frances A. Champagne,Ana C. D'Alessio,Shakti Sharma,Jonathan R. Seckl,Sergiy Dymov,Moshe Szyf,Michael J. Meaney +8 more
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Journal ArticleDOI
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
Luca Santarelli,Michael Saxe,Cornelius Gross,Alexandre Surget,Fortunato Battaglia,Stephanie C. Dulawa,Noelia V. Weisstaub,James T. Lee,Ronald S. Duman,Ottavio Arancio,Catherine Belzung,René Hen +11 more
TL;DR: It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
Journal ArticleDOI
A Syndrome produced by Diverse Nocuous Agents
TL;DR: If the organism is severely damaged by acute non-specific nocuous agents such as exposure to cold, surgical injury, production of spinal shock, excessive muscular exercise, or intoxications with sublethal doses of diverse drugs, a typical syndrome appears, the symptoms of which are independent of the nature of the damaging agent or the pharmacological type of the drug employed.