Targeting VEGF/VEGFR to Modulate Antitumor Immunity.
Ju Yang,Jing Yan,Baorui Liu +2 more
TLDR
A review of the latest clinical and preclinical findings on the modulatory role of antiangiogenic agents targeting VEGF/VEGFR in immune cells, including effector T cells, Tregs, MDSCs, DCs, tumor-associated macrophages, and mast cells will be potentially helpful for the development of combinations of angiogenesis inhibitors with immunological modulators.Abstract:
In addition to the crucial role in promoting the growth of tumor vessels, vascular endothelial growth factor (VEGF) is also immunosuppressive. VEGF can inhibit the function of T cells, increase the recruitment of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and hinder the differentiation and activation of dendritic cells (DCs). Recent studies have investigated the role of antiangiogenic agents in antitumor immunity, especially in recent 3 years. Therefore, it is necessary to update the role of targeting VEGF/VEGFR in antitumor immunity. In this review, we focus on the latest clinical and preclinical findings on the modulatory role of antiangiogenic agents targeting VEGF/VEGFR in immune cells, including effector T cells, Tregs, MDSCs, DCs, tumor-associated macrophages, and mast cells. Our review will be potentially helpful for the development of combinations of angiogenesis inhibitors with immunological modulators.read more
Citations
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Tumor angiogenesis: causes, consequences, challenges and opportunities.
TL;DR: The current understanding of cellular and molecular mechanisms involved in tumor angiogenesis is summarized and challenges and opportunities associated with vascular targeting are discussed.
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CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment
Marina Martinez,Edmund K. Moon +1 more
TL;DR: The structure and costimulatory domains chosen for the CAR may play an important role in the overall function of CAR T cells in the TME, and “armored” CARs that secrete cytokines and third- and fourth-generation CARs with multiple costimulation domains offer ways to enhance CAR T cell function.
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Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook.
Josep Garcia,Herbert Hurwitz,Alan Sandler,David Miles,Robert L. Coleman,Regula Deurloo,Olivier Chinot +6 more
TL;DR: Overall, bevacizumab is expected to remain a key agent in cancer therapy, both due to its established efficacy in approved indications and its promise as a partner in novel targeted combination treatments.
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Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma
Josep M. Llovet,Josep M. Llovet,Thierry de Baere,Thierry de Baere,Laura Kulik,Philipp K. Haber,Tim F. Greten,Tim Meyer,Tim Meyer,Riccardo Lencioni +9 more
TL;DR: In this paper, the authors analyse data from randomized and uncontrolled studies reported with ablative and locoregional techniques and examine the expected effects of combinations with systemic treatments, and discuss trial design and benchmarks to be used as a reference for future investigations in a promising new era for HCC treatment.
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Brain immunology and immunotherapy in brain tumours
TL;DR: How advances in the understanding of the immune system within the brain have implications for the successful implementation of immunotherapy to treat brain tumours is discussed, despite challenges such as effective delivery, target specificity and intratumour heterogeneity.
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