Journal ArticleDOI
Tat-BMPs-PAMAM conjugates enhance therapeutic effect of small interference RNA on U251 glioma cells in vitro and in vivo.
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TLDR
Results show that Tat-BMPs-PAMAM, with its targeted delivery and transmembrane ability, may be a novel gene delivery system with potential applications in the targeted gene therapy of brain tumors.Abstract:
Han and colleagues engineer an existing nonviral biocarrier based on polyamidoamine dendrimers to deliver an interfering RNA to downregulate expression of the oncogenic epidermal growth factor receptor in gliomas. To enable cell targeting and entry, and eventual transduction, portions of the HIV-1 Tat protein and magnetic nanoparticle technology were incorporated in the design.read more
Citations
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Cell-penetrating peptides: breaking through to the other side
Erez Koren,Vladimir P. Torchilin +1 more
TL;DR: The rationales for the design of 'smart' pharmaceutical nanocarriers in which the cell-penetrating properties are hidden until triggered by exposure to appropriate environmental conditions (e.g., a particular pH, temperature, or enzyme level) are discussed.
Journal ArticleDOI
Surface-engineered dendrimers in gene delivery.
TL;DR: The results allowed us to assess the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.
Journal ArticleDOI
Efficient and targeted delivery of siRNA in vivo.
Min Suk Shim,Young Jik Kwon +1 more
TL;DR: Major challenges in achieving efficient siRNA delivery in vivo are introduced and recent advances in overcoming them are discussed using chemically modified siRNA, viral siRNA vectors and nonviral siRNA carriers.
Journal ArticleDOI
Magnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects
TL;DR: This review discusses magnetic formulations of vectors for nucleic acid delivery and their characterization, mechanisms of magnetofection, and the application of magnet ofection in viral and nonviral nucleic acids delivery in cell culture and in animal models.
Journal ArticleDOI
Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors.
Yuebin Shan,Ting Luo,Chen Peng,Ruilong Sheng,Amin Cao,Xueyan Cao,Mingwu Shen,Rui Guo,Helena Tomás,Xiangyang Shi,Xiangyang Shi +10 more
TL;DR: A new gene delivery vector based on dendrimer-entrapped gold nanoparticles (Au DENPs) with significantly higher gene transfection efficiency than that of dendricers without AuNPs entrapped is reported.
References
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Journal ArticleDOI
Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells.
Maïté Lewin,Nadia Carlesso,Ching-Hsuan Tung,Xiaowu Tang,David G. Cory,David T. Scadden,Ralph Weissleder +6 more
TL;DR: A cell labeling approach using short HIV-Tat peptides to derivatize superparamagnetic nanoparticles is developed, which efficiently internalized into hematopoietic and neural progenitor cells in quantities up to 10–30 pg of super paramagnetic iron per cell.
Journal ArticleDOI
The EGF receptor family as targets for cancer therapy.
John Mendelsohn,José Baselga +1 more
TL;DR: The role of these active anti-receptor agents in the treatment of patients with cancer is addressed and compounds that directly inhibit receptor tyrosine kinases have shown preclinical activity and early clinical activity has been reported.
Journal ArticleDOI
Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials.
TL;DR: A small but clear improvement in survival from chemotherapy is shown, which encourages further study of drug treatment of these tumours.
Journal ArticleDOI
High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates.
TL;DR: A biocompatible, dextran coated superparamagnetic iron oxide particle was derivatized with a peptide sequence from the HIV-tat protein to improve intracellular magnetic labeling of different target cells, and internalized into lymphocytes over 100-fold more efficiently than nonmodified particles.
PatentDOI
Cell Penetrating Peptides
Mattias Hällbrink,Margus Pooga,Madis Tallin Unive Metsis,Priit Kogerman,Andreas Valkna,Anne Meikas,Maria Lindgren,Astrid Gräslund,Göran Eriksson,Claes Göran Östensson,Metka V. Budihna,Matjaz Zorko,Anna Elmquist,Ursel Soomets,Pontus Lundberg,Peter Järver,Külliki Saar,Samir El-Andaloussi,Kalle Kilk,Ülo Langel +19 more
TL;DR: In this paper, a method for predicting or designing, detecting, and/or verifying a novel cell-penetrating peptide (CPP) was proposed and used for treating and preventing a medical condition.