The microenvironment in mature B-cell malignancies: a target for new treatment strategies
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TLDR
A paradigm shift in the treatment of selected B-cell malignancies is anticipated, moving from targeting primarily the malignant cells toward combining cytotoxic drugs with agents that interfere with the microenvironment's proactive role.About:
This article is published in Blood.The article was published on 2009-10-15 and is currently open access. It has received 543 citations till now.read more
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Dissertation
Caractérisation d'anomalies cytogénétiques et moléculaires dans la leucémie lymphoïde chronique
TL;DR: Results revelent egalement that le Selinexor est inefficace pour induire l'apoptose dans les cellules LLC-B mute pour XPO1 avant de decider d'un traitement of the LLC.
Journal ArticleDOI
Heterogeneity of mesenchymal stromal cells in lymphoproliferative disorders.
TL;DR: Functional alterations and immunophenotypic abnormalities in MSC obtained from HM patients seem to confirm the defective biological pattern of MSC especially in myeloid diseases, while MSC cytogenetic profile in HM is still an open question, because it is not clear whether BM stromal cells are "culprit or bystander" displaying or not an abnormal karyotype.
Journal ArticleDOI
Improving treatment for patients with chronic lymphocytic leukemia
TL;DR: In this paper, the authors summarize Mayo Clinic's recent efforts to improve CIT for patients with chronic lymphocytic lymphoma (CLL) by targeting pathways critical to CLL B-cell survival including targeting leukemia cell apoptotic resistance, survival signals mediated through the Bcell receptor, and nurturing interactions with the microenvironment.
Book ChapterDOI
New Protein Markers of Chronic Lymphocytic and Acute Lymphocytic Leukemia
TL;DR: There is an urgent need for the application of new protein markers in early and personalized prognostic diagnosis of cancer, and numerous important discoveries have recently been published regarding new proteins and their pathology-related modifications, which may play important roles in the onset and progression of leukemia.
Journal ArticleDOI
Effects of ibrutinib on T-cell immunity in patients with chronic lymphocytic leukemia
TL;DR: The current evidence for the effects of ibrutinib on the tumor microenvironment and cellular immunity of patients with CLL is summarized, its potential mechanisms are explored, and a basis for the clinical benefits of long-term ibrUTinib treatment and combined therapy based on T-cell-based immunotherapies is provided.
References
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Journal ArticleDOI
Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
Journal ArticleDOI
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
TL;DR: Macrophages within the tumor microenvironment facilitate angiogenesis and extracellular-matrix breakdown and remodeling and promote tumor cell motility and are an important drug target for cancer therapy.
Journal ArticleDOI
Conditions controlling the proliferation of haemopoietic stem cells in vitro.
TL;DR: A liquid culture system is described whereby proliferation of haemopoietic stem cells, production of granulocyte precursor cells (CFU‐C), and extensive granulopoiesis can be maintained in vitro for several months.
Journal ArticleDOI
Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches
TL;DR: It is shown that the induced deletion of CXCR4, a receptor for CXC chemokine ligand (CXCL) 12 in adult mice, resulted in severe reduction of HSC numbers and increased sensitivity to myelotoxic injury, although it did not impair expansion of the more mature progenitors.
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