The microenvironment in mature B-cell malignancies: a target for new treatment strategies
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TLDR
A paradigm shift in the treatment of selected B-cell malignancies is anticipated, moving from targeting primarily the malignant cells toward combining cytotoxic drugs with agents that interfere with the microenvironment's proactive role.About:
This article is published in Blood.The article was published on 2009-10-15 and is currently open access. It has received 543 citations till now.read more
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Journal ArticleDOI
New drug discovery approaches targeting recurrent mutations in chronic lymphocytic leukemia.
Rupal Tripathi,Eriong Lee-Vergés,Morihiro Higashi,Neus Giménez,Laia Rosich,Mónica López-Guerra,Dolors Colomer +6 more
TL;DR: The potential role of new targeted therapies against the most recurrent mutations in CLL as well as the recently approved therapies are uncovered and expert opinion is provided.
Dissertation
Synergism of IL10R and TLR9 signaling affects gene expression, proliferation and metabolism in B cells: A comparative study of STAT3/NF-kB and c-Myc mediated effects
TL;DR: A new role for IL10R and TLR9 signaling and the interaction of STAT3 and NF-kB signaling in gGE, proliferation and metabolism of B cells was identified that might also be important for lymphomagenesis.
Journal ArticleDOI
CAM-DR: Mechanisms, Roles and Clinical Application in Tumors.
TL;DR: In this paper, the main signal transduction pathways that are involved in the enhancement of the cancer cells' survival are discussed, and therapies targeting interactions between cancer cells and their environment to enhance drug response or prevent the emergence of drug resistance are also discussed.
Journal ArticleDOI
Molecular signatures in the diagnosis and management of follicular lymphoma.
TL;DR: Recent insights into follicular lymphoma identify constitutional and environmental predisposition further unravelling the concept of a lymphoma-initiating cell and the acquired events defining this disease.
Journal ArticleDOI
Where is the biology of CLL leading us
References
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Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
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Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
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TL;DR: A liquid culture system is described whereby proliferation of haemopoietic stem cells, production of granulocyte precursor cells (CFU‐C), and extensive granulopoiesis can be maintained in vitro for several months.
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