The microenvironment in mature B-cell malignancies: a target for new treatment strategies
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TLDR
A paradigm shift in the treatment of selected B-cell malignancies is anticipated, moving from targeting primarily the malignant cells toward combining cytotoxic drugs with agents that interfere with the microenvironment's proactive role.About:
This article is published in Blood.The article was published on 2009-10-15 and is currently open access. It has received 543 citations till now.read more
Citations
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Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44
Suping Zhang,Christina C.N. Wu,Jessie-F. Fecteau,Bing Cui,Liguang Chen,Ling Zhang,Rongrong Wu,Laura Z. Rassenti,Fitzgerald S Lao,Stefan Weigand,Thomas J. Kipps +10 more
TL;DR: Studies indicate that this humanized mAb specific for CD44 might have therapeutic activity, particularly in patients with CLL that express ZAP-70, which was found was complexed with CD44.
Journal ArticleDOI
Ex-Vivo Dynamic 3-D Culture of Human Tissues in the RCCS™ Bioreactor Allows the Study of Multiple Myeloma Biology and Response to Therapy
Marina Ferrarini,Nathalie Steimberg,Maurilio Ponzoni,Daniela Belloni,Angiola Berenzi,Stefania Girlanda,Federico Caligaris-Cappio,Giovanna Mazzoleni,Elisabetta Ferrero +8 more
TL;DR: 3-D, RCCS™ bioreactor-based culture of tissue explants can be exploited for studying myeloma biology and for a pre-clinical approach to patient-targeted therapy, as a proof of principle.
Journal ArticleDOI
NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms
TL;DR: The physiologic role of the NF-κB pathway and recent advances in better understanding of the pathologic roles are presented and an update of clinical trials that use NF-σB pathway inhibitors is provided.
Journal ArticleDOI
Stereotypical Chronic Lymphocytic Leukemia B-Cell Receptors Recognize Survival Promoting Antigens on Stromal Cells
Mascha Binder,Barbara Léchenne,Ramesh Ummanni,Christan Scharf,Stefan Balabanov,Maria Trusch,Hartmut Schlüter,Ingke Braren,Edzard Spillner,Martin Trepel +9 more
TL;DR: CLL BCR stimulation by stroma-derived antigens can contribute to the protective effect that the stroma exerts on CLL cells, which sheds a new light on the understanding of the pathobiology of this so far mostly incurable disease.
Journal ArticleDOI
Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals
TL;DR: It is demonstrated that the HSP90 inhibitor 17‐DMAG exhibited synergy with dasatinib in vitro, and moreover, induced apoptosis of CLL cells in the CD154L/IL‐4 system.
References
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