Journal ArticleDOI
The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification.
Jason A. Young,Quinton L. Fivelman,Peter L. Blair,Patricia de la Vega,Karine G. Le Roch,Yingyao Zhou,Daniel J. Carucci,David A. Baker,Elizabeth A. Winzeler +8 more
TLDR
Light is shed on the components of molecular mechanisms underlying parasite sexual development and other areas of malarial parasite biology by applying a novel knowledge-based data-mining algorithm termed ontology-based pattern identification (OPI).About:
This article is published in Molecular and Biochemical Parasitology.The article was published on 2005-09-01. It has received 345 citations till now. The article focuses on the topics: Gene expression profiling.read more
Citations
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The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum
TL;DR: Analysis of the complete asexual intraerythrocytic developmental cycle (IDC) transcriptome of the HB3 strain of P. falciparum demonstrates that this parasite has evolved an extremely specialized mode of transcriptional regulation that produces a continuous cascade of gene expression, beginning with genes corresponding to general cellular processes, such as protein synthesis, and ending with Plasmodium-specific functionalities.
Journal ArticleDOI
Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry
TL;DR: Activity-based protein profiling (ABPP) has emerged as a powerful chemical proteomic strategy to characterize enzyme function directly in native biological systems on a global scale as mentioned in this paper, and the basic technology of ABPP, the enzyme classes addressable by this method, and the biological discoveries attributable to its application.
Journal ArticleDOI
Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination
Teun Bousema,Chris Drakeley +1 more
TL;DR: How control measures that aim to reduce malaria transmission, such as mass drug administration and a transmission-blocking vaccine, might better be deployed are drawn together to show how the application of molecular techniques has led to the identification of submicroscopic gametocyte carriage and to a reassessment of the human infectious reservoir.
Journal ArticleDOI
Mechanism-based profiling of enzyme families.
TL;DR: Drawing conceptual and methodological inspiration from the success of genomic technologies, the field of proteomics has introduced several strategies for the global analysis of protein expression and function.
Journal ArticleDOI
Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites
Tobias Sargeant,Tobias Sargeant,Matthias Marti,Elisabet Caler,Jane M. Carlton,Ken M. Simpson,Terence P. Speed,Alan F. Cowman +7 more
TL;DR: Data suggest radiation of genes encoding remodeling and virulence factors from a small number of loci in a common Plasmodium ancestor, and imply a closer phylogenetic relationship between the P. vivax and P. falciparum lineages than previously believed.
References
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Journal ArticleDOI
Cluster analysis and display of genome-wide expression patterns
TL;DR: A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression, finding in the budding yeast Saccharomyces cerevisiae that clustering gene expression data groups together efficiently genes of known similar function.
Journal ArticleDOI
Human malaria parasites in continuous culture
William Trager,James B. Jensen +1 more
TL;DR: Plasmodium falciparum can now be maintained in continuous culture in human erythrocytes incubated at 38 degrees C in RPMI 1640 medium with human serum under an atmosphere with 7 percent carbon dioxide and low oxygen.
Journal ArticleDOI
Genome sequence of the human malaria parasite Plasmodium falciparum
Malcolm J. Gardner,Neil Hall,Eula Fung,Owen White,Matthew Berriman,Richard W. Hyman,Jane M. Carlton,Arnab Pain,Karen E. Nelson,Sharen Bowman,Ian T. Paulsen,Keith D. James,Jonathan A. Eisen,Kim Rutherford,Steven L. Salzberg,Alister Craig,Sue Kyes,Man Suen Chan,Vishvanath Nene,Shamira J. Shallom,Bernard B. Suh,Jeremy Peterson,Samuel V. Angiuoli,Mihaela Pertea,Jonathan E. Allen,Jeremy D. Selengut,Daniel H. Haft,Michael W. Mather,Akhil B. Vaidya,David M. A. Martin,Alan H. Fairlamb,Martin Fraunholz,David S. Roos,Stuart A. Ralph,Geoffrey I. McFadden,Leda M. Cummings,G. Mani Subramanian,Christopher J. Mungall,J. Craig Venter,Daniel J. Carucci,Stephen L. Hoffman,Chris I. Newbold,Ronald W. Davis,Claire M. Fraser,Bart Barrell +44 more
TL;DR: The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria.
Journal ArticleDOI
Synchronization of Plasmodium falciparum erythrocytic stages in culture.
TL;DR: Synchronous development of the erythrocytic stages of a human malaria parasite, Plasmodium falciparum, in culture was accomplished by suspending cultured parasites in 5% D-sorbitol and subsequent reintroduction into culture.
Journal ArticleDOI
The global distribution of clinical episodes of Plasmodium falciparum malaria
TL;DR: It is estimated that there were 515 (range 300–660) million episodes of clinical P. falciparum malaria in 2002, up to 50% higher than those reported by the World Health Organization and 200% higher for areas outside Africa, reflecting the WHO's reliance upon passive national reporting for these countries.
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