The thiol pool in human plasma: the central contribution of albumin to redox processes.
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TLDR
A critical review of the plasma thiol pool is provided with a focus on human serum albumin, an important target for oxidants and electrophiles due to its reactivity with a wide variety of species and its relatively high concentration.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Human serum albumin & Thiol.read more
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Investigation of thiol-disulfite homeostasis in blood transfusions in emergency department
TL;DR: Amaç and Yöntemler as discussed by the authorsardırçın amacı, acil serviste farklı miktarlarda, oksidatif stres faktörlerinden thiol-disülfit homeostazisini değerlendirip; oksidef stres düzeyi için bir belirteç olarak kullanılıp kulla-lmayacağını araştırmaktır.
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Assessment of oxidative stress markers in elderly patients with SARS-CoV-2 infection and potential prognostic implications in the medium and long term
Nestor Vazquez-Agra,Ana-Teresa Marques-Afonso,Antón Cruces-Sande,Ignacio Novo-Veleiro,Antonio Pose-Reino,Estefanía Méndez-Álvarez,Ramón Soto-Otero,Álvaro Hermida-Ameijeiras +7 more
TL;DR: Assessment of some parameters related to oxidative stress may help identify groups of patients with a higher risk of morbidity, mortality and delayed immune response during and after SARS-CoV-2 infection.
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The Combined Administration of Vitamin C and Copper Induces a Systemic Oxidative Stress and Kidney Injury
TL;DR: In this paper , the in vivo administration of vitamin C (ascorbic acid; AA) and copper (Cu2+) may cause kidney injury. But, when they are used in combination, the Fenton reaction occurs, leading to the formation of highly reactive hydroxyl radicals.
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Inhibition of an organophosphate-detoxifying bacterial phosphotriesterase by albumin and plasma thiol components
TL;DR: In this article, the BdPTE mutant 10-2C3(C59M/C227A) was found to be inhibited by serum albumin, either via the known high-affinity zinc binding site of albumin or via chemical complex formation with its free thiol side chain at position Cys34.
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Does risk of hyperhomocysteinemia depend on thiol-disulfide exchange reactions of albumin and homocysteine?
Lucia Coppo,Simona Scheggi,Graziella DeMontis,Raffaella Priora,Simona Frosali,Antonios Margaritis,Domenico Summa,Danila DiGiuseppe,Monica Ulivelli,Paolo Cherubini DiSimplicio +9 more
TL;DR: In this paper , the authors suggest that homocysteinylated albumin could be a new pathological factor, and that studies on the redox role of albumin and mixed disulfide production via thiol-disulfide exchange reactions could offer new therapeutic insights for reducing Hcy toxicity.
References
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Bilirubin is an antioxidant of possible physiological importance
TL;DR: The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.
Book
All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
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Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
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Homocysteine and Cardiovascular Disease
TL;DR: In this article, an elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism.
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Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.