The thiol pool in human plasma: the central contribution of albumin to redox processes.
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TLDR
A critical review of the plasma thiol pool is provided with a focus on human serum albumin, an important target for oxidants and electrophiles due to its reactivity with a wide variety of species and its relatively high concentration.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Human serum albumin & Thiol.read more
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Alteration of Blood Oxidative Stress Status in Patients with Thoracic Aortic Dissection: A Pilot Study
Joël Pincemail,Vincent Tchana-Sato,Audrey Courtois,Lucia Musumeci,Jean-Paul Cheramy-Bien,Jacobine Munten,Nicos Labropoulos,Jean-Olivier Defraigne,Natzi Sakalihasan +8 more
TL;DR: In this paper , a pilot study on 18 Thoracic aortic dissection patients revealed a heightened systemic OSS, determined at 15.5 days (median) after the initial diagnosis, in those TAD patients without complications (malperfusion syndrome and aneurysm formation).
Journal ArticleDOI
Total thiol can contribute to differentiating prostate cancer from BPH: Prostate Thiol Index as a new player.
TL;DR: In this paper, a new parameter, prostate thiol index (PTI), was proposed to assess the distinctiveness of serum native thiol, total thiol (TT), and disulfide (SS) levels in PCa patients.
Journal ArticleDOI
Correlation between Blunted Nocturnal Decrease in Diastolic Blood Pressure and Oxidative Stress: An Observational Study
Nestor Vazquez-Agra,Antón Cruces-Sande,Estefanía Méndez-Álvarez,Ramón Soto-Otero,Sergio Cinza-Sanjurjo,JoséE. López-Paz,Antonio Pose-Reino,Álvaro Hermida-Ameijeiras +7 more
TL;DR: In this article , Wu et al. found that an impaired nocturnal decrease in diastolic blood pressure (DBP) increases the blood pressure load, which is a main factor in endothelial dysfunction, atherosclerosis, and arterial stiffness.
Journal ArticleDOI
Advanced EPI-X4 Derivatives Covalently Bind Human Serum Albumin Resulting in Prolonged Plasma Stability
Armando Rodríguez Alfonso,Astrid Johanna Heck,Yasser B. Ruiz-Blanco,Andrea Gilg,Ludger Ständker,Seah Ling Kuan,Tanja Weil,Elsa Sanchez-Garcia,Sebastian Wiese,Jan Münch,Mirja Harms +10 more
TL;DR: In this paper , the authors studied the plasma stability of EPI-X4 lead compounds WSC02 and JM#21, using mass spectrometry to monitor the chemical integrity of the peptides and a functional fluorescence-based assay to determine peptide function in a CXCR4-antibody competition assay.
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Thiol disulfide homeostasis in psychiatric disorders: A comprehensive review
TL;DR: In this paper , the authors identified the studies that examined the thiol-disulfide homeostasis in psychiatric disorders and found that most cases demonstrated alterations in thiol disulfide balance.
References
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Bilirubin is an antioxidant of possible physiological importance
TL;DR: The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.
Book
All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
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Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
Journal ArticleDOI
Homocysteine and Cardiovascular Disease
TL;DR: In this article, an elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism.
Journal ArticleDOI
Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.