The thiol pool in human plasma: the central contribution of albumin to redox processes.
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TLDR
A critical review of the plasma thiol pool is provided with a focus on human serum albumin, an important target for oxidants and electrophiles due to its reactivity with a wide variety of species and its relatively high concentration.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Human serum albumin & Thiol.read more
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Acute Kidney Injury is Associated with Lowered Plasma-Free Thiol Levels.
Lisanne Boekhoud,Jacqueline Koeze,Elisabeth C. van der Slikke,Arno R. Bourgonje,Jill Moser,Jan G. Zijlstra,Anneke C. Muller Kobold,Marian Bulthuis,Matijs van Meurs,Harry van Goor,Hjalmar R. Bouma +10 more
TL;DR: It is hypothesized that plasma-free thiols are associated with AKI upon admission to the intensive care unit (ICU) and albumin-adjusted free thiol levels were significantly reduced in patients withAKI and patients with sepsis compared with patients without AKI and sepsi.
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The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling Lipid
Lucía Turell,Dario A. Vitturi,E. Laura Coitiño,Lourdes Lebrato,Matías N. Möller,Camila Sagasti,Sonia R. Salvatore,Steven R. Woodcock,Beatriz Alvarez,Francisco J. Schopfer +9 more
TL;DR: This work examined the reactions of NO2-CLA with low molecular weight thiols and human serum albumin and found the detection of cysteine-δ-adducts in human urine provided evidence for the biological relevance of this reaction, providing new insights into the chemical basis of NO1-CLA signaling actions.
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Acute effect of Clitoria ternatea flower beverage on glycemic response and antioxidant capacity in healthy subjects: a randomized crossover trial
Charoonsri Chusak,Thavaree Thilavech,Christiani Jeyakumar Henry,Christiani Jeyakumar Henry,Sirichai Adisakwattana +4 more
TL;DR: It is suggested that an acute ingestion of CTE increases plasma antioxidant capacity without hypoglycemia in the fasting state and improves postprandial glucose, insulin and antioxidant status when consumed with sucrose.
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The thiol of human serum albumin: Acidity, microenvironment and mechanistic insights on its oxidation to sulfenic acid.
Jenner Bonanata,Lucía Turell,Laura Antmann,Gerardo Ferrer-Sueta,Santiago Botasini,Eduardo Méndez,Beatriz Alvarez,E. Laura Coitiño +7 more
TL;DR: Three experimental approaches are used to determine that the pKa value in delipidated HSA is 8.1±0.2 at 37 °C and 0.1 M ionic strength, and clues on the key aspects that modulate thiol reactivity against H2O2 are provided.
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High-Resolution Accurate-Mass Mass Spectrometry Enabling In-Depth Characterization of in Vivo Biotransformations for Intact Antibody-Drug Conjugates
Jintang He,Dian Su,Carl Ng,Luna Liu,Shang-Fan Yu,Thomas H. Pillow,Geoffrey Del Rosario,Martine Darwish,Byoung-Chul Lee,Rachana Ohri,H. Zhou,Xueji Wang,Jiawei Lu,Surinder Kaur,Keyang Xu +14 more
TL;DR: HR/AM Orbitrap MS approach was particularly beneficial for characterizing ADC modifications with small mass changes such as partial drug loss and hydrolysis, and significantly enhanced the capability to elucidate ADC biotransformations and help understand ADC efficacy and safety in vivo.
References
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Bilirubin is an antioxidant of possible physiological importance
TL;DR: The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.
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All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
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Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
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Homocysteine and Cardiovascular Disease
TL;DR: In this article, an elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism.
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Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.